Case report: quetiapine-induced transient elevation of activated partial thromboplastin time
We report a case of 3-year old Pakistani boy who was previously well and brought to the hospital because of an accidental ingestion of quetiapine 8 hours before admission. No gastric lavage or activated charcoal done because of late presentation. He developed headache, excessive drinking and slee...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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International Journal Development Research
2020
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| Online Access: | http://irep.iium.edu.my/80307/ http://irep.iium.edu.my/80307/1/80307_Case%20Report%20Quetiapine-induced%20transient%20elevation.pdf |
| _version_ | 1848788934107070464 |
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| author | Elghuwael, Ismail Mohamed Omar Abdullah, Wan Ariffin |
| author_facet | Elghuwael, Ismail Mohamed Omar Abdullah, Wan Ariffin |
| author_sort | Elghuwael, Ismail Mohamed Omar |
| building | IIUM Repository |
| collection | Online Access |
| description | We report a case of 3-year old Pakistani boy who was previously well and brought to
the hospital because of an accidental ingestion of quetiapine 8 hours before admission.
No gastric lavage or activated charcoal done because of late presentation. He developed
headache, excessive drinking and sleepiness few hours post ingestion but his symptoms
resolved before arrival. His laboratory work up (Full blood count, blood urea and serum
electrolytes, liver function test and coagulation profile) showed only an elevated
activated Partial Thromboplastin Time (APTT). The patient was discharged after 24
hours. We checked APTTweekly. Even though, he remained well clinically his APTT
continued to be high until after 1.5 months of ingestion when repeated APTT was
normalized. Review at literature reported many anti-psychotics including quetiapine can
cause an elevation of Prothrombin Time (PT) and APTT and low platelet count in adult
patients taking them regularly [6], drug overdose can cause APTT elevation as well [4].
We conclude that this 3 years old child has quetiapine-induced transient elevation of
APTT. |
| first_indexed | 2025-11-14T17:48:42Z |
| format | Article |
| id | iium-80307 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:48:42Z |
| publishDate | 2020 |
| publisher | International Journal Development Research |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-803072021-01-18T04:18:00Z http://irep.iium.edu.my/80307/ Case report: quetiapine-induced transient elevation of activated partial thromboplastin time Elghuwael, Ismail Mohamed Omar Abdullah, Wan Ariffin RJ101 Child Heatlh. Child health services. Preventive health services for children We report a case of 3-year old Pakistani boy who was previously well and brought to the hospital because of an accidental ingestion of quetiapine 8 hours before admission. No gastric lavage or activated charcoal done because of late presentation. He developed headache, excessive drinking and sleepiness few hours post ingestion but his symptoms resolved before arrival. His laboratory work up (Full blood count, blood urea and serum electrolytes, liver function test and coagulation profile) showed only an elevated activated Partial Thromboplastin Time (APTT). The patient was discharged after 24 hours. We checked APTTweekly. Even though, he remained well clinically his APTT continued to be high until after 1.5 months of ingestion when repeated APTT was normalized. Review at literature reported many anti-psychotics including quetiapine can cause an elevation of Prothrombin Time (PT) and APTT and low platelet count in adult patients taking them regularly [6], drug overdose can cause APTT elevation as well [4]. We conclude that this 3 years old child has quetiapine-induced transient elevation of APTT. International Journal Development Research 2020-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/80307/1/80307_Case%20Report%20Quetiapine-induced%20transient%20elevation.pdf Elghuwael, Ismail Mohamed Omar and Abdullah, Wan Ariffin (2020) Case report: quetiapine-induced transient elevation of activated partial thromboplastin time. International Journal of Development Research, 10 (4). pp. 35078-35080. ISSN 2230-9926 https://www.journalijdr.com/sites/default/files/issue-pdf/18645.pdf 18645 |
| spellingShingle | RJ101 Child Heatlh. Child health services. Preventive health services for children Elghuwael, Ismail Mohamed Omar Abdullah, Wan Ariffin Case report: quetiapine-induced transient elevation of activated partial thromboplastin time |
| title | Case report: quetiapine-induced transient elevation of activated partial thromboplastin time |
| title_full | Case report: quetiapine-induced transient elevation of activated partial thromboplastin time |
| title_fullStr | Case report: quetiapine-induced transient elevation of activated partial thromboplastin time |
| title_full_unstemmed | Case report: quetiapine-induced transient elevation of activated partial thromboplastin time |
| title_short | Case report: quetiapine-induced transient elevation of activated partial thromboplastin time |
| title_sort | case report: quetiapine-induced transient elevation of activated partial thromboplastin time |
| topic | RJ101 Child Heatlh. Child health services. Preventive health services for children |
| url | http://irep.iium.edu.my/80307/ http://irep.iium.edu.my/80307/ http://irep.iium.edu.my/80307/ http://irep.iium.edu.my/80307/1/80307_Case%20Report%20Quetiapine-induced%20transient%20elevation.pdf |