Case report: quetiapine-induced transient elevation of activated partial thromboplastin time
We report a case of 3-year old Pakistani boy who was previously well and brought to the hospital because of an accidental ingestion of quetiapine 8 hours before admission. No gastric lavage or activated charcoal done because of late presentation. He developed headache, excessive drinking and slee...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
International Journal Development Research
2020
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/80307/ http://irep.iium.edu.my/80307/1/80307_Case%20Report%20Quetiapine-induced%20transient%20elevation.pdf |
| Summary: | We report a case of 3-year old Pakistani boy who was previously well and brought to
the hospital because of an accidental ingestion of quetiapine 8 hours before admission.
No gastric lavage or activated charcoal done because of late presentation. He developed
headache, excessive drinking and sleepiness few hours post ingestion but his symptoms
resolved before arrival. His laboratory work up (Full blood count, blood urea and serum
electrolytes, liver function test and coagulation profile) showed only an elevated
activated Partial Thromboplastin Time (APTT). The patient was discharged after 24
hours. We checked APTTweekly. Even though, he remained well clinically his APTT
continued to be high until after 1.5 months of ingestion when repeated APTT was
normalized. Review at literature reported many anti-psychotics including quetiapine can
cause an elevation of Prothrombin Time (PT) and APTT and low platelet count in adult
patients taking them regularly [6], drug overdose can cause APTT elevation as well [4].
We conclude that this 3 years old child has quetiapine-induced transient elevation of
APTT. |
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