Cytotoxic xanthones isolated from calophyllum depressinervosum and calophyllum buxifolium with antioxidant and cytotoxic activities
The stem bark of Calophyllum depressinervosum and Calophyllum buxifolium were extracted and examined for their antioxidant activities, together with cytotoxicity towards human cancer cells. The methanol extract of C. depressinervosum exhibited good DPPH and NO scavenging effects. The strongest BCB...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English English English |
| Published: |
Elsevier Ltd
2019
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/79802/ http://irep.iium.edu.my/79802/1/79802_Cytotoxic%20xanthones%20isolated%20from%20Calophyllum_article.pdf http://irep.iium.edu.my/79802/2/79802_Cytotoxic%20xanthones%20isolated%20from%20Calophyllum_scopus.pdf http://irep.iium.edu.my/79802/3/79802_Cytotoxic%20xanthones%20isolated%20from%20Calophyllum_wos.pdf |
| _version_ | 1848788846499594240 |
|---|---|
| author | Zamakshshari, Nor Hisam Ee, Gwendoline Cheng Lian Ismail, Intan Safinar Ibrahim, Zalikha Mah, Siau Hui |
| author_facet | Zamakshshari, Nor Hisam Ee, Gwendoline Cheng Lian Ismail, Intan Safinar Ibrahim, Zalikha Mah, Siau Hui |
| author_sort | Zamakshshari, Nor Hisam |
| building | IIUM Repository |
| collection | Online Access |
| description | The stem bark of Calophyllum depressinervosum and Calophyllum buxifolium were extracted and examined for their
antioxidant activities, together with cytotoxicity towards human cancer cells. The methanol extract of C.
depressinervosum exhibited good DPPH and NO scavenging effects. The strongest BCB inhibition and FIC effects
were shown by dichloromethane and ethyl acetate extracts of both species. Overall, DPPH, FRAP and FIC assays
showed strong correlation with TPC. For cytotoxicity, hexane extract of C. depressinervosum possessed the strongest
anti-proliferative activities towards SNU-1 cells while the hexane extract of C. buxifolium showed the strongest activity
towards LS-174T and K562 cells with the IC values ranging from 7 to 17 μg/mL. The purification of plant extracts
afforded eight xanthones, ananixanthone (1), caloxanthone B (2), caloxanthone I (3), caloxanthone J (4) xanthochymone
B (5), thwaitesixanthone (6), 1,3,5,6-tetrahydroxyxanthone (7) and dombakinaxanthone (8). All the xanthones, except 1
were reported for the first time from both Calophyllum species. The xanthones were examined for their cytotoxic effect
against K562 leukemic cells. Compounds 1 and 2 showed strong cytotoxicity with the IC values of 2.96 and 1.23
μg/mL, respectively. The molecular binding interaction of 2 was further investigated by performing molecular docking
study with promising protein receptor Src kinase. |
| first_indexed | 2025-11-14T17:47:19Z |
| format | Article |
| id | iium-79802 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:47:19Z |
| publishDate | 2019 |
| publisher | Elsevier Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-798022020-06-24T09:03:15Z http://irep.iium.edu.my/79802/ Cytotoxic xanthones isolated from calophyllum depressinervosum and calophyllum buxifolium with antioxidant and cytotoxic activities Zamakshshari, Nor Hisam Ee, Gwendoline Cheng Lian Ismail, Intan Safinar Ibrahim, Zalikha Mah, Siau Hui QR Microbiology RC Internal medicine SB Plant culture The stem bark of Calophyllum depressinervosum and Calophyllum buxifolium were extracted and examined for their antioxidant activities, together with cytotoxicity towards human cancer cells. The methanol extract of C. depressinervosum exhibited good DPPH and NO scavenging effects. The strongest BCB inhibition and FIC effects were shown by dichloromethane and ethyl acetate extracts of both species. Overall, DPPH, FRAP and FIC assays showed strong correlation with TPC. For cytotoxicity, hexane extract of C. depressinervosum possessed the strongest anti-proliferative activities towards SNU-1 cells while the hexane extract of C. buxifolium showed the strongest activity towards LS-174T and K562 cells with the IC values ranging from 7 to 17 μg/mL. The purification of plant extracts afforded eight xanthones, ananixanthone (1), caloxanthone B (2), caloxanthone I (3), caloxanthone J (4) xanthochymone B (5), thwaitesixanthone (6), 1,3,5,6-tetrahydroxyxanthone (7) and dombakinaxanthone (8). All the xanthones, except 1 were reported for the first time from both Calophyllum species. The xanthones were examined for their cytotoxic effect against K562 leukemic cells. Compounds 1 and 2 showed strong cytotoxicity with the IC values of 2.96 and 1.23 μg/mL, respectively. The molecular binding interaction of 2 was further investigated by performing molecular docking study with promising protein receptor Src kinase. Elsevier Ltd 2019-11 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/79802/1/79802_Cytotoxic%20xanthones%20isolated%20from%20Calophyllum_article.pdf application/pdf en http://irep.iium.edu.my/79802/2/79802_Cytotoxic%20xanthones%20isolated%20from%20Calophyllum_scopus.pdf application/pdf en http://irep.iium.edu.my/79802/3/79802_Cytotoxic%20xanthones%20isolated%20from%20Calophyllum_wos.pdf Zamakshshari, Nor Hisam and Ee, Gwendoline Cheng Lian and Ismail, Intan Safinar and Ibrahim, Zalikha and Mah, Siau Hui (2019) Cytotoxic xanthones isolated from calophyllum depressinervosum and calophyllum buxifolium with antioxidant and cytotoxic activities. Food and Chemical Toxicology, 133. ISSN 0278-6915 E-ISSN 873-6351 https://www.sciencedirect.com/science/article/pii/S0278691519305903 10.1016/j.fct.2019.110800 |
| spellingShingle | QR Microbiology RC Internal medicine SB Plant culture Zamakshshari, Nor Hisam Ee, Gwendoline Cheng Lian Ismail, Intan Safinar Ibrahim, Zalikha Mah, Siau Hui Cytotoxic xanthones isolated from calophyllum depressinervosum and calophyllum buxifolium with antioxidant and cytotoxic activities |
| title | Cytotoxic xanthones isolated from calophyllum depressinervosum and calophyllum buxifolium with antioxidant and cytotoxic activities |
| title_full | Cytotoxic xanthones isolated from calophyllum depressinervosum and calophyllum buxifolium with antioxidant and cytotoxic activities |
| title_fullStr | Cytotoxic xanthones isolated from calophyllum depressinervosum and calophyllum buxifolium with antioxidant and cytotoxic activities |
| title_full_unstemmed | Cytotoxic xanthones isolated from calophyllum depressinervosum and calophyllum buxifolium with antioxidant and cytotoxic activities |
| title_short | Cytotoxic xanthones isolated from calophyllum depressinervosum and calophyllum buxifolium with antioxidant and cytotoxic activities |
| title_sort | cytotoxic xanthones isolated from calophyllum depressinervosum and calophyllum buxifolium with antioxidant and cytotoxic activities |
| topic | QR Microbiology RC Internal medicine SB Plant culture |
| url | http://irep.iium.edu.my/79802/ http://irep.iium.edu.my/79802/ http://irep.iium.edu.my/79802/ http://irep.iium.edu.my/79802/1/79802_Cytotoxic%20xanthones%20isolated%20from%20Calophyllum_article.pdf http://irep.iium.edu.my/79802/2/79802_Cytotoxic%20xanthones%20isolated%20from%20Calophyllum_scopus.pdf http://irep.iium.edu.my/79802/3/79802_Cytotoxic%20xanthones%20isolated%20from%20Calophyllum_wos.pdf |