Cytotoxic and antibacterial activities of marine sponge-derived fungus aspergillus nomius NC06
Sponge-derived fungi have attracted recent attention due to its important source of interesting biologically active compounds. In our previous study, we have obtained 13 fungi from marine sponge Neopetrsiachaliniformis. Among them, only Aspergillus nomius NC06 showed cytotoxic activity with the pe...
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| Format: | Article |
| Language: | English English |
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Rasayan Journal
2019
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| Online Access: | http://irep.iium.edu.my/79801/ http://irep.iium.edu.my/79801/1/79801_Cytotoxic%20and%20antibacterial%20activities%20of%20marine%20_article_new.pdf http://irep.iium.edu.my/79801/2/79801_Cytotoxic%20and%20antibacterial%20activities%20of%20marine%20_scopus.pdf |
| _version_ | 1848788846155661312 |
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| author | Artasasta, Muh. Ade ., Yanwirasti Bakhtiar, Muhammad Taher Djamaan, Akmal Handayani, Dian |
| author_facet | Artasasta, Muh. Ade ., Yanwirasti Bakhtiar, Muhammad Taher Djamaan, Akmal Handayani, Dian |
| author_sort | Artasasta, Muh. Ade |
| building | IIUM Repository |
| collection | Online Access |
| description | Sponge-derived fungi have attracted recent attention due to its important source of interesting biologically active
compounds. In our previous study, we have obtained 13 fungi from marine sponge Neopetrsiachaliniformis. Among
them, only Aspergillus nomius NC06 showed cytotoxic activity with the percentage of viability113.9 % and 70.31 %
of Vero cell and WiDr colon cancer cell, respectively. This study aimed to isolate the cytotoxic compound from the
ethyl acetate extract of N. nomius NC06 using chromatography method. A total of 5 fractions of the extract obtained
using vacuum liquid chromatography. These fractions were tested against HCT 116 colon cancer cell and ten human
pathogenic bacteria. Fraction II, III, IV, and V showed cytotoxic activity with IC50 of 5.28, 15.82, 10.27, and
45.57 µg/mL, respectively. In antibacterial testing, fraction II and III were potential because of their ability to inhibit
the growth of ten pathogenic bacteria with the diameter of inhibition zone more than 12 mm |
| first_indexed | 2025-11-14T17:47:18Z |
| format | Article |
| id | iium-79801 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:47:18Z |
| publishDate | 2019 |
| publisher | Rasayan Journal |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-798012020-06-24T08:19:15Z http://irep.iium.edu.my/79801/ Cytotoxic and antibacterial activities of marine sponge-derived fungus aspergillus nomius NC06 Artasasta, Muh. Ade ., Yanwirasti Bakhtiar, Muhammad Taher Djamaan, Akmal Handayani, Dian QL Zoology QR Microbiology TP Chemical technology Sponge-derived fungi have attracted recent attention due to its important source of interesting biologically active compounds. In our previous study, we have obtained 13 fungi from marine sponge Neopetrsiachaliniformis. Among them, only Aspergillus nomius NC06 showed cytotoxic activity with the percentage of viability113.9 % and 70.31 % of Vero cell and WiDr colon cancer cell, respectively. This study aimed to isolate the cytotoxic compound from the ethyl acetate extract of N. nomius NC06 using chromatography method. A total of 5 fractions of the extract obtained using vacuum liquid chromatography. These fractions were tested against HCT 116 colon cancer cell and ten human pathogenic bacteria. Fraction II, III, IV, and V showed cytotoxic activity with IC50 of 5.28, 15.82, 10.27, and 45.57 µg/mL, respectively. In antibacterial testing, fraction II and III were potential because of their ability to inhibit the growth of ten pathogenic bacteria with the diameter of inhibition zone more than 12 mm Rasayan Journal 2019 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/79801/1/79801_Cytotoxic%20and%20antibacterial%20activities%20of%20marine%20_article_new.pdf application/pdf en http://irep.iium.edu.my/79801/2/79801_Cytotoxic%20and%20antibacterial%20activities%20of%20marine%20_scopus.pdf Artasasta, Muh. Ade and ., Yanwirasti and Bakhtiar, Muhammad Taher and Djamaan, Akmal and Handayani, Dian (2019) Cytotoxic and antibacterial activities of marine sponge-derived fungus aspergillus nomius NC06. Rasayan Journal of Chemistry, 12 (3). pp. 1463-1469. ISSN 0974-1496 E-ISSN 0976-0083 https://rasayanjournal.co.in/admin/php/upload/727_pdf.pdf 10.31788/RJC.2019.1235284 |
| spellingShingle | QL Zoology QR Microbiology TP Chemical technology Artasasta, Muh. Ade ., Yanwirasti Bakhtiar, Muhammad Taher Djamaan, Akmal Handayani, Dian Cytotoxic and antibacterial activities of marine sponge-derived fungus aspergillus nomius NC06 |
| title | Cytotoxic and antibacterial activities of marine sponge-derived fungus aspergillus nomius NC06 |
| title_full | Cytotoxic and antibacterial activities of marine sponge-derived fungus aspergillus nomius NC06 |
| title_fullStr | Cytotoxic and antibacterial activities of marine sponge-derived fungus aspergillus nomius NC06 |
| title_full_unstemmed | Cytotoxic and antibacterial activities of marine sponge-derived fungus aspergillus nomius NC06 |
| title_short | Cytotoxic and antibacterial activities of marine sponge-derived fungus aspergillus nomius NC06 |
| title_sort | cytotoxic and antibacterial activities of marine sponge-derived fungus aspergillus nomius nc06 |
| topic | QL Zoology QR Microbiology TP Chemical technology |
| url | http://irep.iium.edu.my/79801/ http://irep.iium.edu.my/79801/ http://irep.iium.edu.my/79801/ http://irep.iium.edu.my/79801/1/79801_Cytotoxic%20and%20antibacterial%20activities%20of%20marine%20_article_new.pdf http://irep.iium.edu.my/79801/2/79801_Cytotoxic%20and%20antibacterial%20activities%20of%20marine%20_scopus.pdf |