Cytotoxic and antibacterial activities of marine sponge-derived fungus aspergillus nomius NC06
Sponge-derived fungi have attracted recent attention due to its important source of interesting biologically active compounds. In our previous study, we have obtained 13 fungi from marine sponge Neopetrsiachaliniformis. Among them, only Aspergillus nomius NC06 showed cytotoxic activity with the pe...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English English |
| Published: |
Rasayan Journal
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/79801/ http://irep.iium.edu.my/79801/1/79801_Cytotoxic%20and%20antibacterial%20activities%20of%20marine%20_article_new.pdf http://irep.iium.edu.my/79801/2/79801_Cytotoxic%20and%20antibacterial%20activities%20of%20marine%20_scopus.pdf |
| Summary: | Sponge-derived fungi have attracted recent attention due to its important source of interesting biologically active
compounds. In our previous study, we have obtained 13 fungi from marine sponge Neopetrsiachaliniformis. Among
them, only Aspergillus nomius NC06 showed cytotoxic activity with the percentage of viability113.9 % and 70.31 %
of Vero cell and WiDr colon cancer cell, respectively. This study aimed to isolate the cytotoxic compound from the
ethyl acetate extract of N. nomius NC06 using chromatography method. A total of 5 fractions of the extract obtained
using vacuum liquid chromatography. These fractions were tested against HCT 116 colon cancer cell and ten human
pathogenic bacteria. Fraction II, III, IV, and V showed cytotoxic activity with IC50 of 5.28, 15.82, 10.27, and
45.57 µg/mL, respectively. In antibacterial testing, fraction II and III were potential because of their ability to inhibit
the growth of ten pathogenic bacteria with the diameter of inhibition zone more than 12 mm |
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