Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases
Many drugs have been designed to treat diseases of the central nervous system (CNS), especially neurodegenerative diseases. However, the presence of tight junctions at the blood-brain barrier has often compromised the efficiency of drug delivery to target sites in the brain. The principles of drug d...
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| Format: | Article |
| Language: | English English English |
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Bentham Science Publishers
2019
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| Online Access: | http://irep.iium.edu.my/79799/ http://irep.iium.edu.my/79799/19/79799_Crossing%20the%20Blood-Brain%20Barrier_article_new.pdf http://irep.iium.edu.my/79799/2/79799_Crossing%20the%20Blood-Brain%20Barrier_scopus.pdf http://irep.iium.edu.my/79799/3/79799_Crossing%20the%20Blood-Brain%20Barrier_wos.pdf |
| _version_ | 1848788845573701632 |
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| author | Mansor, Nur Izzati Nordin, Norshariza Mohamed, Farahidah Ling, King-Hwa Rosli, Rozita Hassan, Zurina |
| author_facet | Mansor, Nur Izzati Nordin, Norshariza Mohamed, Farahidah Ling, King-Hwa Rosli, Rozita Hassan, Zurina |
| author_sort | Mansor, Nur Izzati |
| building | IIUM Repository |
| collection | Online Access |
| description | Many drugs have been designed to treat diseases of the central nervous system (CNS), especially neurodegenerative diseases. However, the presence of tight junctions at the blood-brain barrier has often compromised the efficiency of drug delivery to target sites in the brain. The principles of drug delivery systems across the blood-brain barrier are dependent on substrate-specific (i.e. protein transport and transcytosis) and non-specific (i.e. transcellular and paracellular) transport pathways, which are crucial factors in attempts to design efficient drug delivery strategies. This review describes how the blood-brain barrier presents the main challenge in delivering drugs to treat brain diseases and discusses the advantages and disadvantages of ongoing neurotherapeutic delivery strategies in overcoming this limitation. In addition, we discuss the application of colloidal carrier systems, particularly nanoparticles, as potential tools for therapy for the CNS diseases. |
| first_indexed | 2025-11-14T17:47:18Z |
| format | Article |
| id | iium-79799 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:47:18Z |
| publishDate | 2019 |
| publisher | Bentham Science Publishers |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-797992020-06-25T00:47:13Z http://irep.iium.edu.my/79799/ Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases Mansor, Nur Izzati Nordin, Norshariza Mohamed, Farahidah Ling, King-Hwa Rosli, Rozita Hassan, Zurina RS192 Materia Medica-Pharmaceutical Technology Many drugs have been designed to treat diseases of the central nervous system (CNS), especially neurodegenerative diseases. However, the presence of tight junctions at the blood-brain barrier has often compromised the efficiency of drug delivery to target sites in the brain. The principles of drug delivery systems across the blood-brain barrier are dependent on substrate-specific (i.e. protein transport and transcytosis) and non-specific (i.e. transcellular and paracellular) transport pathways, which are crucial factors in attempts to design efficient drug delivery strategies. This review describes how the blood-brain barrier presents the main challenge in delivering drugs to treat brain diseases and discusses the advantages and disadvantages of ongoing neurotherapeutic delivery strategies in overcoming this limitation. In addition, we discuss the application of colloidal carrier systems, particularly nanoparticles, as potential tools for therapy for the CNS diseases. Bentham Science Publishers 2019 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/79799/19/79799_Crossing%20the%20Blood-Brain%20Barrier_article_new.pdf application/pdf en http://irep.iium.edu.my/79799/2/79799_Crossing%20the%20Blood-Brain%20Barrier_scopus.pdf application/pdf en http://irep.iium.edu.my/79799/3/79799_Crossing%20the%20Blood-Brain%20Barrier_wos.pdf Mansor, Nur Izzati and Nordin, Norshariza and Mohamed, Farahidah and Ling, King-Hwa and Rosli, Rozita and Hassan, Zurina (2019) Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases. Current Drug Delivery, 16 (8). pp. 698-711. ISSN 1567-2018 (In Press) http://www.eurekaselect.com/node/174513/article/crossing-the-blood-brain-barrier-a-review-on-drug-delivery-strategies-for-treatment-of-the-central-nervous-system-diseases 10.2174/1567201816666190828153017 |
| spellingShingle | RS192 Materia Medica-Pharmaceutical Technology Mansor, Nur Izzati Nordin, Norshariza Mohamed, Farahidah Ling, King-Hwa Rosli, Rozita Hassan, Zurina Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases |
| title | Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases |
| title_full | Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases |
| title_fullStr | Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases |
| title_full_unstemmed | Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases |
| title_short | Crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases |
| title_sort | crossing the blood-brain barrier: a review on drug delivery strategies for treatment of the central nervous system diseases |
| topic | RS192 Materia Medica-Pharmaceutical Technology |
| url | http://irep.iium.edu.my/79799/ http://irep.iium.edu.my/79799/ http://irep.iium.edu.my/79799/ http://irep.iium.edu.my/79799/19/79799_Crossing%20the%20Blood-Brain%20Barrier_article_new.pdf http://irep.iium.edu.my/79799/2/79799_Crossing%20the%20Blood-Brain%20Barrier_scopus.pdf http://irep.iium.edu.my/79799/3/79799_Crossing%20the%20Blood-Brain%20Barrier_wos.pdf |