Contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches
Dengue virus (DENV) is an arboviral human pathogen transmitted through mosquito bite that infects an estimated ~400 million humans (~5% of the global population) annually. To date, no specific therapeutics have been developed that can prevent or treat infections resulting from this pathogen. DENV...
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| Format: | Article |
| Language: | English English English |
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MDPI AG
2019
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| Online Access: | http://irep.iium.edu.my/79793/ http://irep.iium.edu.my/79793/1/79793_Contemporary%20Strategies%20and%20Current%20Trends_article.pdf http://irep.iium.edu.my/79793/2/79793_Contemporary%20Strategies%20and%20Current%20Trends_scopus.pdf http://irep.iium.edu.my/79793/3/79793_Contemporary%20Strategies%20and%20Current%20Trends_wos.pdf |
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| author | Ahammad, Foysal Tengku Abd Rashid, Tengku Rogayah Mohamed, Maizan Tanbin, Suriyea Ahmad Fuad, Fazia Adyani |
| author_facet | Ahammad, Foysal Tengku Abd Rashid, Tengku Rogayah Mohamed, Maizan Tanbin, Suriyea Ahmad Fuad, Fazia Adyani |
| author_sort | Ahammad, Foysal |
| building | IIUM Repository |
| collection | Online Access |
| description | Dengue virus (DENV) is an arboviral human pathogen transmitted through mosquito bite that infects an estimated
~400 million humans (~5% of the global population) annually. To date, no specific therapeutics have been developed
that can prevent or treat infections resulting from this pathogen. DENV utilizes numerous host molecules and factors
for transcribing the single-stranded ~11 kb positive-sense RNA genome. For example, the glycosylation machinery of
the host is required for viral particles to assemble in the endoplasmic reticulum. Since a variety of host factors seem
to be utilized by the pathogens, targeting these factors may result in DENV inhibitors, and will play an important
role in attenuating the rapid emergence of other flaviviruses. Many experimental studies have yielded findings
indicating that host factors facilitate infection, indicating that the focus should be given to targeting the processes
contributing to pathogenesis along with many other immune responses. Here, we provide an extensive literature
review in order to elucidate the progress made in the development of host-based approaches for DENV viral
infections, focusing on host cellular mechanisms and factors responsible for viral replication, aiming to aid the
potential development of host-dependent antiviral therapeutics. |
| first_indexed | 2025-11-14T17:47:16Z |
| format | Article |
| id | iium-79793 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:47:16Z |
| publishDate | 2019 |
| publisher | MDPI AG |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-797932020-03-24T09:09:21Z http://irep.iium.edu.my/79793/ Contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches Ahammad, Foysal Tengku Abd Rashid, Tengku Rogayah Mohamed, Maizan Tanbin, Suriyea Ahmad Fuad, Fazia Adyani TP248.13 Biotechnology Dengue virus (DENV) is an arboviral human pathogen transmitted through mosquito bite that infects an estimated ~400 million humans (~5% of the global population) annually. To date, no specific therapeutics have been developed that can prevent or treat infections resulting from this pathogen. DENV utilizes numerous host molecules and factors for transcribing the single-stranded ~11 kb positive-sense RNA genome. For example, the glycosylation machinery of the host is required for viral particles to assemble in the endoplasmic reticulum. Since a variety of host factors seem to be utilized by the pathogens, targeting these factors may result in DENV inhibitors, and will play an important role in attenuating the rapid emergence of other flaviviruses. Many experimental studies have yielded findings indicating that host factors facilitate infection, indicating that the focus should be given to targeting the processes contributing to pathogenesis along with many other immune responses. Here, we provide an extensive literature review in order to elucidate the progress made in the development of host-based approaches for DENV viral infections, focusing on host cellular mechanisms and factors responsible for viral replication, aiming to aid the potential development of host-dependent antiviral therapeutics. MDPI AG 2019-09 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/79793/1/79793_Contemporary%20Strategies%20and%20Current%20Trends_article.pdf application/pdf en http://irep.iium.edu.my/79793/2/79793_Contemporary%20Strategies%20and%20Current%20Trends_scopus.pdf application/pdf en http://irep.iium.edu.my/79793/3/79793_Contemporary%20Strategies%20and%20Current%20Trends_wos.pdf Ahammad, Foysal and Tengku Abd Rashid, Tengku Rogayah and Mohamed, Maizan and Tanbin, Suriyea and Ahmad Fuad, Fazia Adyani (2019) Contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches. Microorganisms, 7 (9). pp. 1-28. ISSN 2076-2607 https://www.mdpi.com/2076-2607/7/9/296 10.3390/microorganisms7090296 |
| spellingShingle | TP248.13 Biotechnology Ahammad, Foysal Tengku Abd Rashid, Tengku Rogayah Mohamed, Maizan Tanbin, Suriyea Ahmad Fuad, Fazia Adyani Contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches |
| title | Contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches |
| title_full | Contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches |
| title_fullStr | Contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches |
| title_full_unstemmed | Contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches |
| title_short | Contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches |
| title_sort | contemporary strategies and current trends in designing antiviral drugs against dengue fever via targeting host-based approaches |
| topic | TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/79793/ http://irep.iium.edu.my/79793/ http://irep.iium.edu.my/79793/ http://irep.iium.edu.my/79793/1/79793_Contemporary%20Strategies%20and%20Current%20Trends_article.pdf http://irep.iium.edu.my/79793/2/79793_Contemporary%20Strategies%20and%20Current%20Trends_scopus.pdf http://irep.iium.edu.my/79793/3/79793_Contemporary%20Strategies%20and%20Current%20Trends_wos.pdf |