Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel

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Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P K+ channel

Two-pore domain K+ (K2P) channels have many important physiological functions. However, the functional properties of the TWIK-1 (K2P1.1/KCNK1) K2P channel remain poorly characterized because heterologous expression of this ion channel yields only very low levels of functional activity. Several under...

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Bibliographic Details
Main Authors:	Nematian-Ardestani, Ehsan, Abd. Wahab, Mohd. Firdaus, Chatelain, Franck C., Sun, Han, Schewe, Marcus, Baukrowitz, Thomas, Tucker, Stephen J.
Format:	Article
Language:	English English English English
Published:	American Society for Biochemistry and Molecular Biology Publications 2020
Subjects:	QC Physics QP Physiology TP248.13 Biotechnology
Online Access:	http://irep.iium.edu.my/79624/ http://irep.iium.edu.my/79624/1/79624_Selectivity%20filter%20instability%20dominates%20-%20pre-print.pdf http://irep.iium.edu.my/79624/2/79624_Selectivity%20filter%20instability%20dominates_MYRA.pdf http://irep.iium.edu.my/79624/3/79624_Selectivity%20filter%20instability%20dominates_SCOPUS.pdf http://irep.iium.edu.my/79624/4/79624_Selectivity%20filter%20instability%20dominates_WOS.pdf

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