Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach
A selective and sensitive chemosensor for recognizing Co2+ in water sample was optimized from a heterocyclic thiosemicarbazone derivative named 2-acetylpyrazine thiosemicarbazone (AT). The optimization of AT as chemosensor was conducted through RSM experiments using UV- Vis spectroscopy. The interac...
| Main Authors: | , , |
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| Format: | Proceeding Paper |
| Language: | English English |
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2019
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| Online Access: | http://irep.iium.edu.my/79369/ http://irep.iium.edu.my/79369/1/SKAM32%20slide%20print http://irep.iium.edu.my/79369/2/SKAM32%20PROGRAM%20BOOK.pdf |
| _version_ | 1848788759734124544 |
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| author | Ismail, Hakimah Ahmad, Mohammad Norazmi Abdullah, Erna Normaya |
| author_facet | Ismail, Hakimah Ahmad, Mohammad Norazmi Abdullah, Erna Normaya |
| author_sort | Ismail, Hakimah |
| building | IIUM Repository |
| collection | Online Access |
| description | A selective and sensitive chemosensor for recognizing Co2+ in water sample was optimized from a heterocyclic thiosemicarbazone derivative named 2-acetylpyrazine thiosemicarbazone (AT). The optimization of AT as chemosensor was conducted through RSM experiments using UV- Vis spectroscopy. The interaction between AT and Co2+ was found to be optimum in 8:2 v/v DMSO/water at pH 5.3, 100:70 μM AT/Co2+ concentration and 15 minutes reaction time. AT- Co2+ interaction showed colorimetric response from colourless to orange, together with peak- shifting in the absorption spectra from 327 nm to 450 nm. The detection limit of AT towards Co2+ was found to be 3.75 μM while the binding stoichiometry of AT-Co2+ was 2:1. The practicality of AT as chemosensor was tested using three different water samples spiked with Co2+ in the optimized condition. The chemical interaction between AT and Co2+ was further studied through computational studies. DFT calculations for molecular electron potential (MEP), Fukui function and HOMO-LUMO interaction were used to support the experimental results. |
| first_indexed | 2025-11-14T17:45:56Z |
| format | Proceeding Paper |
| id | iium-79369 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:45:56Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-793692020-04-06T13:53:53Z http://irep.iium.edu.my/79369/ Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach Ismail, Hakimah Ahmad, Mohammad Norazmi Abdullah, Erna Normaya QD Chemistry A selective and sensitive chemosensor for recognizing Co2+ in water sample was optimized from a heterocyclic thiosemicarbazone derivative named 2-acetylpyrazine thiosemicarbazone (AT). The optimization of AT as chemosensor was conducted through RSM experiments using UV- Vis spectroscopy. The interaction between AT and Co2+ was found to be optimum in 8:2 v/v DMSO/water at pH 5.3, 100:70 μM AT/Co2+ concentration and 15 minutes reaction time. AT- Co2+ interaction showed colorimetric response from colourless to orange, together with peak- shifting in the absorption spectra from 327 nm to 450 nm. The detection limit of AT towards Co2+ was found to be 3.75 μM while the binding stoichiometry of AT-Co2+ was 2:1. The practicality of AT as chemosensor was tested using three different water samples spiked with Co2+ in the optimized condition. The chemical interaction between AT and Co2+ was further studied through computational studies. DFT calculations for molecular electron potential (MEP), Fukui function and HOMO-LUMO interaction were used to support the experimental results. 2019-08-15 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/79369/1/SKAM32%20slide%20print application/pdf en http://irep.iium.edu.my/79369/2/SKAM32%20PROGRAM%20BOOK.pdf Ismail, Hakimah and Ahmad, Mohammad Norazmi and Abdullah, Erna Normaya (2019) Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach. In: 32nd International Conference of Analytical Sciences (SKAM32), 14-16 August 2019, Port Dickson. (Unpublished) |
| spellingShingle | QD Chemistry Ismail, Hakimah Ahmad, Mohammad Norazmi Abdullah, Erna Normaya Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach |
| title | Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach |
| title_full | Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach |
| title_fullStr | Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach |
| title_full_unstemmed | Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach |
| title_short | Chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach |
| title_sort | chemosensor development for cobalt ion recognition using 2-acetylpyrazine thiosemicarbazone: experimental and theoretical approach |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/79369/ http://irep.iium.edu.my/79369/1/SKAM32%20slide%20print http://irep.iium.edu.my/79369/2/SKAM32%20PROGRAM%20BOOK.pdf |