The promise of zebrafish as a model of metabolic syndrome
Metabolic syndrome is a cluster including hyperglycaemia, obesity, hypertension, and hypertriglyceridaemia as a result of biochemical and physiological alterations and can increase the risk of cardiovascular disease and diabetes. Fundamental research on this disease requires validated animal models....
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| Format: | Article |
| Language: | English English English |
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International Press Editing Centre Incorporation
2019
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| Online Access: | http://irep.iium.edu.my/79119/ http://irep.iium.edu.my/79119/1/79119_The%20promise%20of%20zebrafish.pdf http://irep.iium.edu.my/79119/2/79119_The%20promise%20of%20zebrafish_SCOPUS.pdf http://irep.iium.edu.my/79119/3/79119_The%20promise%20of%20zebrafish_WOS.pdf |
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| author | Benchoula, Khaled Khatib, Alfi Jaffar, Ashika Ahmed, Qamar Uddin Wan Sulaiman, Wan Mohd. Azizi Abdul Wahab, Ridhwan El-Seedi, Hesham |
| author_facet | Benchoula, Khaled Khatib, Alfi Jaffar, Ashika Ahmed, Qamar Uddin Wan Sulaiman, Wan Mohd. Azizi Abdul Wahab, Ridhwan El-Seedi, Hesham |
| author_sort | Benchoula, Khaled |
| building | IIUM Repository |
| collection | Online Access |
| description | Metabolic syndrome is a cluster including hyperglycaemia, obesity, hypertension, and hypertriglyceridaemia as a result of biochemical and physiological alterations and can increase the risk of cardiovascular disease and diabetes. Fundamental research on this disease requires validated animal models. One potential animal model that is rapidly gaining in popularity is zebrafish (Danio rerio). The use of zebrafish as an animal model conveys several advantages, including high human genetic homology, transparent embryos and larvae that allow easier visualization. This review discusses how zebrafish models contribute to the development of metabolic syndrome studies. Different diseases in the cluster of metabolic syndrome, such as hyperglycaemia, obesity, diabetes, and hypertriglyceridaemia, have been successfully studied using zebrafish; and the model is promising for hypertension and cardiovascular metabolic-related diseases due to its genetic similarity to mammals. Genetic mutation, chemical induction, and dietary alteration are among the tools used to improve zebrafish models. This field is expanding, and thus, more effective and efficient techniques are currently developed to fulfil the increasing demand for thorough investigations. Key words: diabetes, hypertension, metabolic syndrome, obesity, zebrafish |
| first_indexed | 2025-11-14T17:45:18Z |
| format | Article |
| id | iium-79119 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:45:18Z |
| publishDate | 2019 |
| publisher | International Press Editing Centre Incorporation |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-791192020-03-26T09:47:49Z http://irep.iium.edu.my/79119/ The promise of zebrafish as a model of metabolic syndrome Benchoula, Khaled Khatib, Alfi Jaffar, Ashika Ahmed, Qamar Uddin Wan Sulaiman, Wan Mohd. Azizi Abdul Wahab, Ridhwan El-Seedi, Hesham R Medicine (General) Metabolic syndrome is a cluster including hyperglycaemia, obesity, hypertension, and hypertriglyceridaemia as a result of biochemical and physiological alterations and can increase the risk of cardiovascular disease and diabetes. Fundamental research on this disease requires validated animal models. One potential animal model that is rapidly gaining in popularity is zebrafish (Danio rerio). The use of zebrafish as an animal model conveys several advantages, including high human genetic homology, transparent embryos and larvae that allow easier visualization. This review discusses how zebrafish models contribute to the development of metabolic syndrome studies. Different diseases in the cluster of metabolic syndrome, such as hyperglycaemia, obesity, diabetes, and hypertriglyceridaemia, have been successfully studied using zebrafish; and the model is promising for hypertension and cardiovascular metabolic-related diseases due to its genetic similarity to mammals. Genetic mutation, chemical induction, and dietary alteration are among the tools used to improve zebrafish models. This field is expanding, and thus, more effective and efficient techniques are currently developed to fulfil the increasing demand for thorough investigations. Key words: diabetes, hypertension, metabolic syndrome, obesity, zebrafish International Press Editing Centre Incorporation 2019-05-21 Article PeerReviewed application/pdf en http://irep.iium.edu.my/79119/1/79119_The%20promise%20of%20zebrafish.pdf application/pdf en http://irep.iium.edu.my/79119/2/79119_The%20promise%20of%20zebrafish_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/79119/3/79119_The%20promise%20of%20zebrafish_WOS.pdf Benchoula, Khaled and Khatib, Alfi and Jaffar, Ashika and Ahmed, Qamar Uddin and Wan Sulaiman, Wan Mohd. Azizi and Abdul Wahab, Ridhwan and El-Seedi, Hesham (2019) The promise of zebrafish as a model of metabolic syndrome. Experimental Animals, 68 (4). pp. 407-416. ISSN 1341-1357 E-ISSN 1881-7122 https://www.jstage.jst.go.jp/article/expanim/68/4/68_18-0168/_pdf/-char/en 10.1538/expanim.18-0168 |
| spellingShingle | R Medicine (General) Benchoula, Khaled Khatib, Alfi Jaffar, Ashika Ahmed, Qamar Uddin Wan Sulaiman, Wan Mohd. Azizi Abdul Wahab, Ridhwan El-Seedi, Hesham The promise of zebrafish as a model of metabolic syndrome |
| title | The promise of zebrafish as a model of metabolic syndrome |
| title_full | The promise of zebrafish as a model of metabolic syndrome |
| title_fullStr | The promise of zebrafish as a model of metabolic syndrome |
| title_full_unstemmed | The promise of zebrafish as a model of metabolic syndrome |
| title_short | The promise of zebrafish as a model of metabolic syndrome |
| title_sort | promise of zebrafish as a model of metabolic syndrome |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/79119/ http://irep.iium.edu.my/79119/ http://irep.iium.edu.my/79119/ http://irep.iium.edu.my/79119/1/79119_The%20promise%20of%20zebrafish.pdf http://irep.iium.edu.my/79119/2/79119_The%20promise%20of%20zebrafish_SCOPUS.pdf http://irep.iium.edu.my/79119/3/79119_The%20promise%20of%20zebrafish_WOS.pdf |