Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors
A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol, respectively. Dichloromethane extract further underwent the acid base treatmen...
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| Format: | Article |
| Language: | English English |
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A and V Publication
2019
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| Online Access: | http://irep.iium.edu.my/78683/ http://irep.iium.edu.my/78683/9/78683_Alkaloids%20from%20Popowia%20perakensis_article_new.pdf http://irep.iium.edu.my/78683/2/78683_Alkaloids%20from%20Popowia%20perakensis_SCOPUS.pdf |
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| author | Syed Abdul Azziz, Saripah Salbiah Mukhtar, Mat Ropi A. Hadi, A. Hamid Mhd Bakri, Yuhanis Aldulaimi, Ahmed Kareem Obaid Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun |
| author_facet | Syed Abdul Azziz, Saripah Salbiah Mukhtar, Mat Ropi A. Hadi, A. Hamid Mhd Bakri, Yuhanis Aldulaimi, Ahmed Kareem Obaid Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun |
| author_sort | Syed Abdul Azziz, Saripah Salbiah |
| building | IIUM Repository |
| collection | Online Access |
| description | A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol, respectively. Dichloromethane extract further underwent the acid base treatment to give the alkaloidal crude extract. Isolation of compounds was carried out using various chromatography techniques including column chromatography and thin layer chromatography. Spectroscopic methods notably 1H, 13C NMR, IR, UV and GC-MS spectroscopy were utilized to identify pure compounds in addition to comparison of reported data. Two azaanthraquinones alkaloids namely cleistopholine 1 and 6-methoxycleistopholine 2 together with simple isoquinolone alkaloid, N-methylcorydaldine 3 had been isolated. All three alkaloids are known but they were isolated for the first time from this species. Cleistopholine 1 was tested for Dipeptidyl peptidase IV (DPP IV) inhibition to investigate its potential antidiabetic activities. Results revealed that this compound showed quite weak (6.26 %) inhibitory activities as compared to the positive control, Diprotin A (81.46 %). The quantity of the other two compounds was insufficient for the screening purposes. |
| first_indexed | 2025-11-14T17:44:13Z |
| format | Article |
| id | iium-78683 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:44:13Z |
| publishDate | 2019 |
| publisher | A and V Publication |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-786832020-02-19T01:01:55Z http://irep.iium.edu.my/78683/ Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors Syed Abdul Azziz, Saripah Salbiah Mukhtar, Mat Ropi A. Hadi, A. Hamid Mhd Bakri, Yuhanis Aldulaimi, Ahmed Kareem Obaid Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun QD Chemistry A study on the alkaloidal composition on the Malaysian Annonaceae species, i.e Popowia perakensis King has been carried out. Barks of Popowia perakensis were extracted with hexane, dichloromethane and methanol, respectively. Dichloromethane extract further underwent the acid base treatment to give the alkaloidal crude extract. Isolation of compounds was carried out using various chromatography techniques including column chromatography and thin layer chromatography. Spectroscopic methods notably 1H, 13C NMR, IR, UV and GC-MS spectroscopy were utilized to identify pure compounds in addition to comparison of reported data. Two azaanthraquinones alkaloids namely cleistopholine 1 and 6-methoxycleistopholine 2 together with simple isoquinolone alkaloid, N-methylcorydaldine 3 had been isolated. All three alkaloids are known but they were isolated for the first time from this species. Cleistopholine 1 was tested for Dipeptidyl peptidase IV (DPP IV) inhibition to investigate its potential antidiabetic activities. Results revealed that this compound showed quite weak (6.26 %) inhibitory activities as compared to the positive control, Diprotin A (81.46 %). The quantity of the other two compounds was insufficient for the screening purposes. A and V Publication 2019 Article PeerReviewed application/pdf en http://irep.iium.edu.my/78683/9/78683_Alkaloids%20from%20Popowia%20perakensis_article_new.pdf application/pdf en http://irep.iium.edu.my/78683/2/78683_Alkaloids%20from%20Popowia%20perakensis_SCOPUS.pdf Syed Abdul Azziz, Saripah Salbiah and Mukhtar, Mat Ropi and A. Hadi, A. Hamid and Mhd Bakri, Yuhanis and Aldulaimi, Ahmed Kareem Obaid and Awang, Khalijah and Hashim, Yumi Zuhanis Has-Yun (2019) Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors. Research Journal of Pharmacy and Technology, 12 (1). pp. 113-116. ISSN 0974-3618 E-ISSN 0974-360X http://www.indianjournals.com/ijor.aspx?target=ijor:rjpt&volume=12&issue=1&article=022 10.5958/0974-360X.2019.00022.2 |
| spellingShingle | QD Chemistry Syed Abdul Azziz, Saripah Salbiah Mukhtar, Mat Ropi A. Hadi, A. Hamid Mhd Bakri, Yuhanis Aldulaimi, Ahmed Kareem Obaid Awang, Khalijah Hashim, Yumi Zuhanis Has-Yun Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors |
| title | Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors |
| title_full | Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors |
| title_fullStr | Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors |
| title_full_unstemmed | Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors |
| title_short | Alkaloids from Popowia perakensis King and their potential as Dipeptidyl peptidase IV (DPP IV) inhibitors |
| title_sort | alkaloids from popowia perakensis king and their potential as dipeptidyl peptidase iv (dpp iv) inhibitors |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/78683/ http://irep.iium.edu.my/78683/ http://irep.iium.edu.my/78683/ http://irep.iium.edu.my/78683/9/78683_Alkaloids%20from%20Popowia%20perakensis_article_new.pdf http://irep.iium.edu.my/78683/2/78683_Alkaloids%20from%20Popowia%20perakensis_SCOPUS.pdf |