The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin
Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB- 231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in...
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| Format: | Article |
| Language: | English |
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Springer New York LLC
2011
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| Online Access: | http://irep.iium.edu.my/7867/ http://irep.iium.edu.my/7867/1/JOCC_41_1866-1871.pdf |
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| author | Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne Rosli, Rozita How, Fiona Ni Foong Watkins, David J. |
| author_facet | Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne Rosli, Rozita How, Fiona Ni Foong Watkins, David J. |
| author_sort | Abdul Manan, Mohd Abdul Fatah |
| building | IIUM Repository |
| collection | Online Access |
| description | Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB- 231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human nonmetastatic mammary gland adenocarcinoma cell line with an IC50 value 0.45 lg/mL. The crystal structure of this centrosymmetric Cu(SMISA)2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur. |
| first_indexed | 2025-11-14T14:37:42Z |
| format | Article |
| id | iium-7867 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T14:37:42Z |
| publishDate | 2011 |
| publisher | Springer New York LLC |
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| spelling | iium-78672013-06-25T02:59:40Z http://irep.iium.edu.my/7867/ The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne Rosli, Rozita How, Fiona Ni Foong Watkins, David J. QD Chemistry Copper(II) complex of S-methyldithiocarbazate with isatin has been prepared and screened for their cytotoxic activities against MCF-7 (Human non-metastatic mammary gland adenocarcinoma cell line) and MDA-MB- 231 (Human metastatic mammary gland adenocarcinoma cell line). The compound crystallized in an orthorhombic crystal system with a space group C 2cb and was found to be selectively active against MCF-7 cell line (Human nonmetastatic mammary gland adenocarcinoma cell line with an IC50 value 0.45 lg/mL. The crystal structure of this centrosymmetric Cu(SMISA)2 complex (SMISA = Schiff base formed by condensation reaction of S-methyldithiocarbazate with isatin) showed that the copper atom has a distorted square-planar geometry with the Schiff base coordinated to the metal ion as a uninegatively charged bidentate ligand through the azomethine nitrogen and thiolate sulfur. Springer New York LLC 2011-10-11 Article PeerReviewed application/pdf en http://irep.iium.edu.my/7867/1/JOCC_41_1866-1871.pdf Abdul Manan, Mohd Abdul Fatah and Mohamed Tahir, Mohamed Ibrahim and Crouse, Karen Anne and Rosli, Rozita and How, Fiona Ni Foong and Watkins, David J. (2011) The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin. Journal of Chemical Crystallography, 41 (12). pp. 1866-1871. ISSN 1074-1542 http://www.springerlink.com/content/05mt681765j6w7qg/ 10.1007/s10870-011-0190-8 |
| spellingShingle | QD Chemistry Abdul Manan, Mohd Abdul Fatah Mohamed Tahir, Mohamed Ibrahim Crouse, Karen Anne Rosli, Rozita How, Fiona Ni Foong Watkins, David J. The crystal structure and cytotoxicity of Centrosymmetric Copper(II) complex derived from S-methyldithiocarbazate with isatin |
| title | The crystal structure and cytotoxicity of Centrosymmetric
Copper(II) complex derived from S-methyldithiocarbazate
with isatin |
| title_full | The crystal structure and cytotoxicity of Centrosymmetric
Copper(II) complex derived from S-methyldithiocarbazate
with isatin |
| title_fullStr | The crystal structure and cytotoxicity of Centrosymmetric
Copper(II) complex derived from S-methyldithiocarbazate
with isatin |
| title_full_unstemmed | The crystal structure and cytotoxicity of Centrosymmetric
Copper(II) complex derived from S-methyldithiocarbazate
with isatin |
| title_short | The crystal structure and cytotoxicity of Centrosymmetric
Copper(II) complex derived from S-methyldithiocarbazate
with isatin |
| title_sort | crystal structure and cytotoxicity of centrosymmetric
copper(ii) complex derived from s-methyldithiocarbazate
with isatin |
| topic | QD Chemistry |
| url | http://irep.iium.edu.my/7867/ http://irep.iium.edu.my/7867/ http://irep.iium.edu.my/7867/ http://irep.iium.edu.my/7867/1/JOCC_41_1866-1871.pdf |