Synthesis and characterization of orotic acid loaded chitosan inclusion complex
Background: Polymeric inclusion complex has been used frequently as a drug delivery system due to controlled release, non-toxic properties and high bioavailability. Objective: The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). Mat...
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2019
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| Online Access: | http://irep.iium.edu.my/77755/ http://irep.iium.edu.my/77755/1/AIPC2019BookofAbstracts-1.pdf http://irep.iium.edu.my/77755/7/AIPC%202019%20helal.pdf |
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| author | Hassani, Abdelkader Azad, Abul Kalam Mia, Abdur Rashid Helal Uddin, A.B.M. |
| author_facet | Hassani, Abdelkader Azad, Abul Kalam Mia, Abdur Rashid Helal Uddin, A.B.M. |
| author_sort | Hassani, Abdelkader |
| building | IIUM Repository |
| collection | Online Access |
| description | Background: Polymeric inclusion complex has been used frequently as a drug delivery system due to controlled release, non-toxic properties and high bioavailability. Objective: The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). Material and methods: The OA/CS
inclusion complex were synthesized using freeze
drying technique. The characterization of inclusion OA/CS was carried out using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffractometry (XRD), Differential Scanning Calorimetry (DSC), Zeta sizer, and Transmission Electron Microscopy (TEM). Results: The FTIR peaks of orotic acid have almost vanished in the
OA/CS spectrum due to the restriction of OA vibration upon loading in CS cavity. The diffraction peaks of the OA/CS are completely diffused due to the amorphous state and the lack of crystallinity of inclusion complex. The DSC marked changes are indicative of the amorphous
phase of solid dispersion, as well OA encapsulation into the nanocavity of CS. The size of OA/CS ranged between 58 nm and 200 nm and the zeta potential was 30 mV. In addition, transmission electron microscopy (TEM) showed
that OA/CS sizes were ranged from 20 to 45 nm. Conclusion: Thus, this study indicates that OA/CS has promising future to further develop a carrier for drug delivery systems. |
| first_indexed | 2025-11-14T17:41:44Z |
| format | Proceeding Paper |
| id | iium-77755 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:41:44Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-777552022-11-07T03:46:07Z http://irep.iium.edu.my/77755/ Synthesis and characterization of orotic acid loaded chitosan inclusion complex Hassani, Abdelkader Azad, Abul Kalam Mia, Abdur Rashid Helal Uddin, A.B.M. QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Background: Polymeric inclusion complex has been used frequently as a drug delivery system due to controlled release, non-toxic properties and high bioavailability. Objective: The current study aims to improve drug release properties of orotic acid loaded with chitosan inclusion complex (OA/CS). Material and methods: The OA/CS inclusion complex were synthesized using freeze drying technique. The characterization of inclusion OA/CS was carried out using Fourier Transform Infrared Spectroscopy (FTIR), X-ray Diffractometry (XRD), Differential Scanning Calorimetry (DSC), Zeta sizer, and Transmission Electron Microscopy (TEM). Results: The FTIR peaks of orotic acid have almost vanished in the OA/CS spectrum due to the restriction of OA vibration upon loading in CS cavity. The diffraction peaks of the OA/CS are completely diffused due to the amorphous state and the lack of crystallinity of inclusion complex. The DSC marked changes are indicative of the amorphous phase of solid dispersion, as well OA encapsulation into the nanocavity of CS. The size of OA/CS ranged between 58 nm and 200 nm and the zeta potential was 30 mV. In addition, transmission electron microscopy (TEM) showed that OA/CS sizes were ranged from 20 to 45 nm. Conclusion: Thus, this study indicates that OA/CS has promising future to further develop a carrier for drug delivery systems. 2019 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/77755/1/AIPC2019BookofAbstracts-1.pdf application/pdf en http://irep.iium.edu.my/77755/7/AIPC%202019%20helal.pdf Hassani, Abdelkader and Azad, Abul Kalam and Mia, Abdur Rashid and Helal Uddin, A.B.M. (2019) Synthesis and characterization of orotic acid loaded chitosan inclusion complex. In: AIMST International Pharmacy Conference (AIPC) 2019: Challenges and Opportunities in Pharmaceutical Sciences, Technology and Practice, 30 November - 1 December 2019, Faculty of Pharmacy, AIMST University, Semeling, Kedah. (Unpublished) |
| spellingShingle | QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Hassani, Abdelkader Azad, Abul Kalam Mia, Abdur Rashid Helal Uddin, A.B.M. Synthesis and characterization of orotic acid loaded chitosan inclusion complex |
| title | Synthesis and characterization of orotic acid loaded chitosan inclusion complex |
| title_full | Synthesis and characterization of orotic acid loaded chitosan inclusion complex |
| title_fullStr | Synthesis and characterization of orotic acid loaded chitosan inclusion complex |
| title_full_unstemmed | Synthesis and characterization of orotic acid loaded chitosan inclusion complex |
| title_short | Synthesis and characterization of orotic acid loaded chitosan inclusion complex |
| title_sort | synthesis and characterization of orotic acid loaded chitosan inclusion complex |
| topic | QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/77755/ http://irep.iium.edu.my/77755/1/AIPC2019BookofAbstracts-1.pdf http://irep.iium.edu.my/77755/7/AIPC%202019%20helal.pdf |