Chronic exposure of low dose organic arsenic induced microscopic changes in rat’s kidney
Introduction: Monosodium methylarsonate (MSMA) is an organic arsenic widely used in agriculture. Humans are exposed to arsenic through drinking water and anthropogenic activities. Chronic exposure to inorganic arsenic has been linked with multiple health problems. However, studies focusing on organi...
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| Format: | Proceeding Paper |
| Language: | English English English |
| Published: |
2019
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| Online Access: | http://irep.iium.edu.my/77438/ http://irep.iium.edu.my/77438/1/Cover%20Page%20SCMSM.pdf http://irep.iium.edu.my/77438/2/List%20Poster%20Presenter.pdf http://irep.iium.edu.my/77438/3/microscopy%20conference%20poster%20v2.pdf |
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| author | Wan Salleh, Wan Muhamad Salahudin A.Talib, Norlelawati Abdullah, Nor Zamzila Aung, Sanda Buyong, Zunariah |
| author_facet | Wan Salleh, Wan Muhamad Salahudin A.Talib, Norlelawati Abdullah, Nor Zamzila Aung, Sanda Buyong, Zunariah |
| author_sort | Wan Salleh, Wan Muhamad Salahudin |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: Monosodium methylarsonate (MSMA) is an organic arsenic widely used in agriculture. Humans are exposed to arsenic through drinking water and anthropogenic activities. Chronic exposure to inorganic arsenic has been linked with multiple health problems. However, studies focusing on organic arsenic effects on kidneys were limited. Objective: To determine the effects of organic arsenic exposure on rat’s kidney. Materials and Method: Twelve male Sprague-Dawley rats were divided into control (n=6) and treated (n=6) groups. Control group was given daily oral gavage of distilled water and treated group was given daily oral gavage of MSMA at 63.0 mg/kg body weight, which was equivalent of 1/30 LD50 of MSMA. After four months, rats urines were collected using metabolic cage and both groups were sacrificed. The urines were analyzed using enzyme-linked immunosorbent assay (ELISA) for neutrophil gelatinase-associated lipocalin (NGAL) biomarkers for kidney injury. The kidneys were harvested for light microscopy study. Results: Urine NGAL significantly higher (p-value <0.05) in treated groups. Light microscopy showed focal glomerular and tubular changes in treated groups. Conclusion: Chronic low dose organic arsenic exposure induced kidney injury. |
| first_indexed | 2025-11-14T17:40:52Z |
| format | Proceeding Paper |
| id | iium-77438 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:40:52Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-774382020-02-04T00:22:20Z http://irep.iium.edu.my/77438/ Chronic exposure of low dose organic arsenic induced microscopic changes in rat’s kidney Wan Salleh, Wan Muhamad Salahudin A.Talib, Norlelawati Abdullah, Nor Zamzila Aung, Sanda Buyong, Zunariah RA1190 Toxicology Introduction: Monosodium methylarsonate (MSMA) is an organic arsenic widely used in agriculture. Humans are exposed to arsenic through drinking water and anthropogenic activities. Chronic exposure to inorganic arsenic has been linked with multiple health problems. However, studies focusing on organic arsenic effects on kidneys were limited. Objective: To determine the effects of organic arsenic exposure on rat’s kidney. Materials and Method: Twelve male Sprague-Dawley rats were divided into control (n=6) and treated (n=6) groups. Control group was given daily oral gavage of distilled water and treated group was given daily oral gavage of MSMA at 63.0 mg/kg body weight, which was equivalent of 1/30 LD50 of MSMA. After four months, rats urines were collected using metabolic cage and both groups were sacrificed. The urines were analyzed using enzyme-linked immunosorbent assay (ELISA) for neutrophil gelatinase-associated lipocalin (NGAL) biomarkers for kidney injury. The kidneys were harvested for light microscopy study. Results: Urine NGAL significantly higher (p-value <0.05) in treated groups. Light microscopy showed focal glomerular and tubular changes in treated groups. Conclusion: Chronic low dose organic arsenic exposure induced kidney injury. 2019-12-18 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/77438/1/Cover%20Page%20SCMSM.pdf application/pdf en http://irep.iium.edu.my/77438/2/List%20Poster%20Presenter.pdf application/pdf en http://irep.iium.edu.my/77438/3/microscopy%20conference%20poster%20v2.pdf Wan Salleh, Wan Muhamad Salahudin and A.Talib, Norlelawati and Abdullah, Nor Zamzila and Aung, Sanda and Buyong, Zunariah (2019) Chronic exposure of low dose organic arsenic induced microscopic changes in rat’s kidney. In: 28th Scientific Conference of Microscopy Society Malaysia, 18th - 20th December 2019, Swiss Garden Beach Resort, Kuantan Pahang. (Unpublished) |
| spellingShingle | RA1190 Toxicology Wan Salleh, Wan Muhamad Salahudin A.Talib, Norlelawati Abdullah, Nor Zamzila Aung, Sanda Buyong, Zunariah Chronic exposure of low dose organic arsenic induced microscopic changes in rat’s kidney |
| title | Chronic exposure of low dose organic arsenic induced microscopic changes in rat’s kidney |
| title_full | Chronic exposure of low dose organic arsenic induced microscopic changes in rat’s kidney |
| title_fullStr | Chronic exposure of low dose organic arsenic induced microscopic changes in rat’s kidney |
| title_full_unstemmed | Chronic exposure of low dose organic arsenic induced microscopic changes in rat’s kidney |
| title_short | Chronic exposure of low dose organic arsenic induced microscopic changes in rat’s kidney |
| title_sort | chronic exposure of low dose organic arsenic induced microscopic changes in rat’s kidney |
| topic | RA1190 Toxicology |
| url | http://irep.iium.edu.my/77438/ http://irep.iium.edu.my/77438/1/Cover%20Page%20SCMSM.pdf http://irep.iium.edu.my/77438/2/List%20Poster%20Presenter.pdf http://irep.iium.edu.my/77438/3/microscopy%20conference%20poster%20v2.pdf |