Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study

QR Code

Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study

Here in this study regarding the over expression of TP, which causes some physical, mental and socio problems like psoriasis, chronic inflammatory disease, tumor angiogenesis and rheumatoid arthritis etc. By this consideration, the inhibition of this enzyme is vital to secure life from serious threa...

Full description

Bibliographic Details
Main Authors:	Zaman, Khalid, Fazal, Rahim, Taha, Muhammad, Wadood, Abdul, Ali Shah, Syed Adnan, Ahmed, Qamar Uddin, Zakaria, Zainul Amiruddin
Format:	Article
Language:	English English English
Published:	Nature Publishing Group 2019
Subjects:	QD Chemistry
Online Access:	http://irep.iium.edu.my/77022/ http://irep.iium.edu.my/77022/1/2019_Qamar%20_KZ_T_Scientific%20Reports.pdf http://irep.iium.edu.my/77022/8/Scopus%20-%20Qamar.pdf http://irep.iium.edu.my/77022/14/77022_Synthesis%20of%20new%20isoquinoline-base-oxadiazole_wos.pdf

Similar Items

Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study
by: Noor Barak, Almandil, et al.
Published: (2019)

Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study
by: Almandil, Noor Barak, et al.
Published: (2019)

Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
by: Taha, Muhammad, et al.
Published: (2019)

Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
by: Taha, Muhammad, et al.
Published: (2019)

Synthesis and in vitro evaluation of 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives as thymidine phosphorylase inhibitors
by: Bera, H., et al.
Published: (2013)

Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1, 5-a][1,3,5]triazines as thymidine phosphorylase inhibitors
by: Sun, L., et al.
Published: (2013)

Synthesis, anti-thymidine phosphorylase activity and molecular docking of 5-thioxo-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ones
by: Bera, H., et al.
Published: (2013)

Discovery of mixed type thymidine phosphorylase inhibitors endowed with antiangiogenic properties: Synthesis, pharmacological evaluation and molecular docking study of 2-thioxo-pyrazolo[1,5-a][1,3,5]triazin-4-ones. Part II
by: Bera, H., et al.
Published: (2014)

Synthesis and biological activity of oxadiazole and triazolothiadiazole derivatives as tyrosinase inhibitors
by: Lam, Kok Wai, et al.
Published: (2010)

Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of Î-Glucuronidase and in silico study
by: Muhammad Taha, et al.
Published: (2021)

Synthesis, in vitro evaluation of thymidine phosphorylase inhibitory activity, and in silico study of 1,3,5-triazin-2,4-dione and its fused analogues
by: Bera, H., et al.
Published: (2013)

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
by: Soong, R., et al.
Published: (2008)

Potent halogenated xanthone derivatives: synthesis, molecular docking and study on antityrosinase activity
by: Baharuddin, Fatin Farhana, et al.
Published: (2023)

Design and Synthesis of Chalcone Derivatives as Potent Tyrosinase Inhibitors and Their Structural Activity Relationship
by: Akhtar, Muhammad Nadeem, et al.
Published: (2015)

Molecular Dynamics Simulation Of Translational And Rotational Diffusion Of Liquid Isoquinoline
by: Ahmad, Norariza
Published: (2010)

Synthesis and molecular docking of carvone derivatives as a potential neuraminidase inhibitors
by: Jusoh, Noorakmar, et al.
Published: (2016)

Analysis of Nucleoside Phosphorylase Polymorphism in Capra Hircus
by: Sekaran, M., et al.
Published: (1989)

Synthesis, characterization and molecular docking of hydroxyxanthone and renylated xanthone derivatives as potential aromatase inhibitor
by: Ramakrishnan, Shurutishria
Published: (2022)

A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5] triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities
by: Bera, H., et al.
Published: (2013)

Annona muricata: A potent anticancer plant
by: Mat So'ad, Siti Zaiton, et al.
Published: (2018)

The Cyclisation of l-Aryl-2-Benzamidoalkan-l-Ols to 4,5-DihydroOxazoles or Isoquinolines
by: Md. Sharif, Atan, et al.
Published: (1990)

Design and Synthesis of New Barbituric- and Thiobarbituric Acid Derivatives as Potent Urease Inhibitors: Structure Activity Relationship and Molecular Modeling Studies
by: Rauf, Abdul, et al.
Published: (2015)

Synthesis, Characterization And Anti-Mycobacterial Activity Of New 1,3,4-Oxadiazole Derivatives
by: Hasmaruddin, Nurul Syazana
Published: (2020)

Crystal structure of 2-(1,3-dioxoindan-2-yl)isoquinoline-1,3,4-trione
by: Ghalib, Raza Murad, et al.
Published: (2015)

The Use of Peptide-Membrane Interactions in the Design of Selective and Potent Sodium Channel Inhibitors
by: Schroeder, C., et al.
Published: (2018)

2-Benzoyl-6-benzylidenecyclohexanone analogs as potent dual inhibitors of acetylcholinesterase and butyrylcholinesterase
by: Sze, Wei Leong, et al.
Published: (2016)

Hierarchical And Fragment Based Virtual Screening Approaches In The Discovery Of Potent Acetylcholinesterase Inhibitor
by: Muhammad, Erma Fatiha
Published: (2022)

Synthesis, anticancer and antimicrobial potential of oxadiazoles
by: Sengupta, Pinaki
Published: (2016)

Virtual screening-based identification of Potent DENV-3 RdRp protease inhibitors via in-house usnic acid derivative database
by: Roney, Miah, et al.
Published: (2021)

Evaluation of potential bacterial protease inhibitor properties of selected hydroxyquinoline derivatives : An in silico docking and molecular dynamics simulation approach
by: Riaz, Faiza, et al.
Published: (2023)

α-Glucosidase inhibitors: consistency of: in silico docking data with in vitro inhibitory data and inhibitory effect prediction of quercetin derivatives
by: Zhu, Jianzhong, et al.
Published: (2019)

Novel phospholipase A2 inhibitors from python serum are potent peptide antibiotics
by: Samy, R., et al.
Published: (2015)

Andrographis paniculata (Burm.f) Wall. ex Ness: a potent antibacterial plant
by: Ahmed, Qamar Uddin, et al.
Published: (2012)

Investigation of α-glucosidase inhibitory metabolites from Tetracera scandens leaves by GC–MS metabolite profiling and docking studies
by: Nokhala, Ahmed, et al.
Published: (2020)

Molecular docking analysis of curcumin analogues as human neutrophil elastase inhibitors
by: Narayanaswamy, Radhakrishnan, et al.
Published: (2014)

Synthesis and effects of oxadiazole derivatives on tyrosinase activity and human SK-MEL-28 malignant melanoma cells
by: Mohd Aluwi, Mohd Fadhlizil Fasihi, et al.
Published: (2016)

The Synthesis and Bioactivity of 2,6-Bisbenzylidenecyclohexanone, Pyrazoline, Chalcone and Oxadiazole Derivatives and Computational Studies on Some of These Compounds
by: Lam, Kok Wai
Published: (2010)

Investigation of α‐glucosidase inhibitory metabolites from Tetracera scandens leaves by GC–MS metabolite profiling and docking studies
by: Ahmed, Nokhala, et al.
Published: (2020)

Development of potent, selective SRPK1 inhibitors as potential topical therapeutics for neovascular eye disease
by: Batson, Jennifer, et al.
Published: (2017)

Molecular docking
by: Abduallah Alsafi, Hassen Mohammed, et al.
Published: (2011)