A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum
Background: Stereospermum fimbriatum or locally known as “Chicha” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. Objective: This study was designed to evaluate the antimicrobial potential of S. fimbriatum’s stem bark against 11 pathogens and isolate its bioacti...
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
2019
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/76986/ http://irep.iium.edu.my/76986/1/Abstract.pdf http://irep.iium.edu.my/76986/7/ID-76986-Oral%20slide.pdf |
| _version_ | 1848788369204576256 |
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| author | Sarker, Md. Zaidul Islam Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Md. Jaffri, Juliana |
| author_facet | Sarker, Md. Zaidul Islam Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Md. Jaffri, Juliana |
| author_sort | Sarker, Md. Zaidul Islam |
| building | IIUM Repository |
| collection | Online Access |
| description | Background: Stereospermum fimbriatum or locally known as “Chicha” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. Objective: This study was designed to evaluate the antimicrobial potential of S. fimbriatum’s stem bark against 11 pathogens and isolate its bioactive compound. Material and methods: Successive soxhlet extraction was conducted using n-hexane, dichloromethane (DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum’s extract. Results: The DCM extract of stem bark (DS) was the most
potent extract followed by n-hexane extract of the
stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 μg/mL to 6.25 μg/mL, against S. epidermidis, MRSA and S. aureus. Conclusion: S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections, specifically, MRSA. |
| first_indexed | 2025-11-14T17:39:44Z |
| format | Proceeding Paper |
| id | iium-76986 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:39:44Z |
| publishDate | 2019 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-769862022-11-08T05:08:07Z http://irep.iium.edu.my/76986/ A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum Sarker, Md. Zaidul Islam Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Md. Jaffri, Juliana RS192 Materia Medica-Pharmaceutical Technology Background: Stereospermum fimbriatum or locally known as “Chicha” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. Objective: This study was designed to evaluate the antimicrobial potential of S. fimbriatum’s stem bark against 11 pathogens and isolate its bioactive compound. Material and methods: Successive soxhlet extraction was conducted using n-hexane, dichloromethane (DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum’s extract. Results: The DCM extract of stem bark (DS) was the most potent extract followed by n-hexane extract of the stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 μg/mL to 6.25 μg/mL, against S. epidermidis, MRSA and S. aureus. Conclusion: S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections, specifically, MRSA. 2019-11-30 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/76986/1/Abstract.pdf application/pdf en http://irep.iium.edu.my/76986/7/ID-76986-Oral%20slide.pdf Sarker, Md. Zaidul Islam and Awang, Anis Fadhlina Izyani and Ahmed, Qamar Uddin and Md. Jaffri, Juliana (2019) A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum. In: AIMST International Pharmacy Conference (AIPC) 2019: Challenges and Opportunities in Pharmaceutical Sciences, Technology and Practice, 30 November - 1 December 2019, Faculty of Pharmacy, AIMST University, Semeling, Kedah. (Unpublished) |
| spellingShingle | RS192 Materia Medica-Pharmaceutical Technology Sarker, Md. Zaidul Islam Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Md. Jaffri, Juliana A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum |
| title | A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum |
| title_full | A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum |
| title_fullStr | A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum |
| title_full_unstemmed | A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum |
| title_short | A novel antibacterial compound from an untapped plant: Stereospermum fimbriatum |
| title_sort | novel antibacterial compound from an untapped plant: stereospermum fimbriatum |
| topic | RS192 Materia Medica-Pharmaceutical Technology |
| url | http://irep.iium.edu.my/76986/ http://irep.iium.edu.my/76986/1/Abstract.pdf http://irep.iium.edu.my/76986/7/ID-76986-Oral%20slide.pdf |