Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines
Myrmecodia pendens (M. pendens) or also known as Sarang semut is an epiphytic plant which might have potential as a new source of alternative therapeutic agent. Recently, it is reported that M. pendens can inhibit the proliferation of HeLa and MCM- B2 cell lines. We report here for the first time...
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| Format: | Proceeding Paper |
| Language: | English English |
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Elsevier
2019
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| Online Access: | http://irep.iium.edu.my/75065/ http://irep.iium.edu.my/75065/9/75065%20%20%20%20%20Preliminary%20investigations%20of%20anti-cancer%20propertie.pdf http://irep.iium.edu.my/75065/8/75065%20Preliminary%20investigations%20of%20anti-cancer%20properties%20SCOPUS.pdf |
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| author | Irfanita, Nining Eddie, Shah Aziz, N.A. Ichwan, Solachuddin J. A. Lestari, Widya |
| author_facet | Irfanita, Nining Eddie, Shah Aziz, N.A. Ichwan, Solachuddin J. A. Lestari, Widya |
| author_sort | Irfanita, Nining |
| building | IIUM Repository |
| collection | Online Access |
| description | Myrmecodia pendens (M. pendens) or also known as Sarang semut is an epiphytic plant which might have potential as a new
source of alternative therapeutic agent. Recently, it is reported that M. pendens can inhibit the proliferation of HeLa and MCM-
B2 cell lines. We report here for the first time the anti-cancer potential of M. pendens on oral cancer cells derived from human
oral cavity, HSC-3 cell lines. MTT assay results showed that M. pendens crude extract markedly induced cytotoxicity on HSC-3
cell lines after 24 h (IC50 = 5 mg/mL) and 48 h (IC50 = 3 mg/ml). The apoptotic activity induced by M. pendens was detected in
HSC-3 cell lines by flow cytometry within 24 h. These results suggest that M. pendens may be a potential candidate for oral
cancer treatment |
| first_indexed | 2025-11-14T17:34:50Z |
| format | Proceeding Paper |
| id | iium-75065 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:34:50Z |
| publishDate | 2019 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-750652019-11-08T02:33:54Z http://irep.iium.edu.my/75065/ Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines Irfanita, Nining Eddie, Shah Aziz, N.A. Ichwan, Solachuddin J. A. Lestari, Widya RK Dentistry Myrmecodia pendens (M. pendens) or also known as Sarang semut is an epiphytic plant which might have potential as a new source of alternative therapeutic agent. Recently, it is reported that M. pendens can inhibit the proliferation of HeLa and MCM- B2 cell lines. We report here for the first time the anti-cancer potential of M. pendens on oral cancer cells derived from human oral cavity, HSC-3 cell lines. MTT assay results showed that M. pendens crude extract markedly induced cytotoxicity on HSC-3 cell lines after 24 h (IC50 = 5 mg/mL) and 48 h (IC50 = 3 mg/ml). The apoptotic activity induced by M. pendens was detected in HSC-3 cell lines by flow cytometry within 24 h. These results suggest that M. pendens may be a potential candidate for oral cancer treatment Elsevier 2019 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/75065/9/75065%20%20%20%20%20Preliminary%20investigations%20of%20anti-cancer%20propertie.pdf application/pdf en http://irep.iium.edu.my/75065/8/75065%20Preliminary%20investigations%20of%20anti-cancer%20properties%20SCOPUS.pdf Irfanita, Nining and Eddie, Shah and Aziz, N.A. and Ichwan, Solachuddin J. A. and Lestari, Widya (2019) Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines. In: Conference on BioMedical and Advanced Materials (Bio-CAM 2017), 28th-29th November 2017, Pulau Langkawi, Kedah. https://www.sciencedirect.com/science/article/pii/S2214785319314592 10.1016/j.matpr.2019.06.110 |
| spellingShingle | RK Dentistry Irfanita, Nining Eddie, Shah Aziz, N.A. Ichwan, Solachuddin J. A. Lestari, Widya Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines |
| title | Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines |
| title_full | Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines |
| title_fullStr | Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines |
| title_full_unstemmed | Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines |
| title_short | Preliminary investigations of anti-cancer properties of Myrmecodia Pendens on human oral cancer HSC-3 cell lines |
| title_sort | preliminary investigations of anti-cancer properties of myrmecodia pendens on human oral cancer hsc-3 cell lines |
| topic | RK Dentistry |
| url | http://irep.iium.edu.my/75065/ http://irep.iium.edu.my/75065/ http://irep.iium.edu.my/75065/ http://irep.iium.edu.my/75065/9/75065%20%20%20%20%20Preliminary%20investigations%20of%20anti-cancer%20propertie.pdf http://irep.iium.edu.my/75065/8/75065%20Preliminary%20investigations%20of%20anti-cancer%20properties%20SCOPUS.pdf |