Insights on the synthesis of asymmetric curcumin derivatives and their biological activities
Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English English |
| Published: |
Elsevier
2019
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/75023/ http://irep.iium.edu.my/75023/1/1-s2.0-S0223523419308566-main.pdf http://irep.iium.edu.my/75023/7/75023_Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin_scopus.pdf |
| _version_ | 1848788054936911872 |
|---|---|
| author | Rullah, Malaysia Mohd Aluwi, Mohd Fadhlizil Fasihi Khor, Poh Yen Kok Wai, Lam |
| author_facet | Rullah, Malaysia Mohd Aluwi, Mohd Fadhlizil Fasihi Khor, Poh Yen Kok Wai, Lam |
| author_sort | Rullah, Malaysia |
| building | IIUM Repository |
| collection | Online Access |
| description | Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine. |
| first_indexed | 2025-11-14T17:34:44Z |
| format | Article |
| id | iium-75023 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:34:44Z |
| publishDate | 2019 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-750232019-10-26T17:24:45Z http://irep.iium.edu.my/75023/ Insights on the synthesis of asymmetric curcumin derivatives and their biological activities Rullah, Malaysia Mohd Aluwi, Mohd Fadhlizil Fasihi Khor, Poh Yen Kok Wai, Lam RS403 Materia Medica-Pharmaceutical Chemistry Curcumin is a small organic molecule with pleiotropic biological activities. However, its multiple structural-pharmacokinetic challenges prevent its development into a clinical drug. Various structural modifications have been made to improve its drug profile. In this review, we focus on the methods adopted in the synthesis of asymmetric curcumin derivatives and their biological activities and forecast the future of this exciting class of compounds in the field of medicine. Elsevier 2019-12-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/75023/1/1-s2.0-S0223523419308566-main.pdf application/pdf en http://irep.iium.edu.my/75023/7/75023_Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin_scopus.pdf Rullah, Malaysia and Mohd Aluwi, Mohd Fadhlizil Fasihi and Khor, Poh Yen and Kok Wai, Lam (2019) Insights on the synthesis of asymmetric curcumin derivatives and their biological activities. European Journal of Medicinal Chemistry, 183. ISSN 0223-5234 https://www.sciencedirect.com/science/article/pii/S0223523419308566 10.1016/j.ejmech.2019.111704 |
| spellingShingle | RS403 Materia Medica-Pharmaceutical Chemistry Rullah, Malaysia Mohd Aluwi, Mohd Fadhlizil Fasihi Khor, Poh Yen Kok Wai, Lam Insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| title | Insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| title_full | Insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| title_fullStr | Insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| title_full_unstemmed | Insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| title_short | Insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| title_sort | insights on the synthesis of asymmetric curcumin derivatives and their biological activities |
| topic | RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/75023/ http://irep.iium.edu.my/75023/ http://irep.iium.edu.my/75023/ http://irep.iium.edu.my/75023/1/1-s2.0-S0223523419308566-main.pdf http://irep.iium.edu.my/75023/7/75023_Insights%20on%20the%20synthesis%20of%20asymmetric%20curcumin_scopus.pdf |