IgE-mediated hypersensitivity to chlorhexidine among first- year dental students
Purpose To investigate immunoglobulin E (IgE)-medi- ated hypersensitivity to chlorhexidine (CHX), and as- sociation between CHX exposure and serum specific IgE (SIgE) levels, among first-year dental students. Methods Participants completed a questionnaire on medical health, history of allergies/hype...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English English |
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Springer Medizin
2019
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| Online Access: | http://irep.iium.edu.my/74563/ http://irep.iium.edu.my/74563/1/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine.pdf http://irep.iium.edu.my/74563/2/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine_MYRA.pdf http://irep.iium.edu.my/74563/3/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine_SCOPUS.pdf |
| _version_ | 1848787979510743040 |
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| author | Mohamed Khazin, Sobrina Abdullah, Dalia Liew, Amy Kia Cheen Harun, Nor Adilah Abdullah, Noormalin Bun, Can Chong |
| author_facet | Mohamed Khazin, Sobrina Abdullah, Dalia Liew, Amy Kia Cheen Harun, Nor Adilah Abdullah, Noormalin Bun, Can Chong |
| author_sort | Mohamed Khazin, Sobrina |
| building | IIUM Repository |
| collection | Online Access |
| description | Purpose To investigate immunoglobulin E (IgE)-medi- ated hypersensitivity to chlorhexidine (CHX), and as- sociation between CHX exposure and serum specific IgE (SIgE) levels, among first-year dental students. Methods Participants completed a questionnaire on medical health, history of allergies/hypersensitivities and CHX exposure. A sample of venous blood (3mL) was drawn and subjected to SIgE test to CHX; sensiti- sation defined as SIgE level of ≥0.10 kUA/L.
Results Fifty-eight (98.3%) participants, consisting of 69% (n=40) female with a mean age of 21, were recruited; three quarters (84%) reported no known health issue, and over half had no history of allergies (57%); less than 20% reported having had exposure to CHX-containing products with the majority from toothpaste (9%) and mouthwash (12%). The CHX SIgE test showed that 8.6% (n = 5) were sensitised. No association between CHX exposure history and the level of SIgE antibody was noted.
Conclusions Although most participants reported no known exposure to CHX, 8.6% showed CHX sensitisa- tion suggesting unknown exposure and the potential risk of developing hypersensitivity and adverse reac- tions in the future. |
| first_indexed | 2025-11-14T17:33:32Z |
| format | Article |
| id | iium-74563 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:33:32Z |
| publishDate | 2019 |
| publisher | Springer Medizin |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-745632020-03-19T07:49:52Z http://irep.iium.edu.my/74563/ IgE-mediated hypersensitivity to chlorhexidine among first- year dental students Mohamed Khazin, Sobrina Abdullah, Dalia Liew, Amy Kia Cheen Harun, Nor Adilah Abdullah, Noormalin Bun, Can Chong RK Dentistry RL Dermatology Purpose To investigate immunoglobulin E (IgE)-medi- ated hypersensitivity to chlorhexidine (CHX), and as- sociation between CHX exposure and serum specific IgE (SIgE) levels, among first-year dental students. Methods Participants completed a questionnaire on medical health, history of allergies/hypersensitivities and CHX exposure. A sample of venous blood (3mL) was drawn and subjected to SIgE test to CHX; sensiti- sation defined as SIgE level of ≥0.10 kUA/L. Results Fifty-eight (98.3%) participants, consisting of 69% (n=40) female with a mean age of 21, were recruited; three quarters (84%) reported no known health issue, and over half had no history of allergies (57%); less than 20% reported having had exposure to CHX-containing products with the majority from toothpaste (9%) and mouthwash (12%). The CHX SIgE test showed that 8.6% (n = 5) were sensitised. No association between CHX exposure history and the level of SIgE antibody was noted. Conclusions Although most participants reported no known exposure to CHX, 8.6% showed CHX sensitisa- tion suggesting unknown exposure and the potential risk of developing hypersensitivity and adverse reac- tions in the future. Springer Medizin 2019-09-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/74563/1/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine.pdf application/pdf en http://irep.iium.edu.my/74563/2/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine_MYRA.pdf application/pdf en http://irep.iium.edu.my/74563/3/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine_SCOPUS.pdf Mohamed Khazin, Sobrina and Abdullah, Dalia and Liew, Amy Kia Cheen and Harun, Nor Adilah and Abdullah, Noormalin and Bun, Can Chong (2019) IgE-mediated hypersensitivity to chlorhexidine among first- year dental students. Allergo Journal International, 28 (6). pp. 204-208. E-ISSN 2197-0378 https://doi.org/10.1007/s40629-019-0103-5 10.1007/s40629-019-0103-5 |
| spellingShingle | RK Dentistry RL Dermatology Mohamed Khazin, Sobrina Abdullah, Dalia Liew, Amy Kia Cheen Harun, Nor Adilah Abdullah, Noormalin Bun, Can Chong IgE-mediated hypersensitivity to chlorhexidine among first- year dental students |
| title | IgE-mediated hypersensitivity to chlorhexidine among first- year dental students |
| title_full | IgE-mediated hypersensitivity to chlorhexidine among first- year dental students |
| title_fullStr | IgE-mediated hypersensitivity to chlorhexidine among first- year dental students |
| title_full_unstemmed | IgE-mediated hypersensitivity to chlorhexidine among first- year dental students |
| title_short | IgE-mediated hypersensitivity to chlorhexidine among first- year dental students |
| title_sort | ige-mediated hypersensitivity to chlorhexidine among first- year dental students |
| topic | RK Dentistry RL Dermatology |
| url | http://irep.iium.edu.my/74563/ http://irep.iium.edu.my/74563/ http://irep.iium.edu.my/74563/ http://irep.iium.edu.my/74563/1/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine.pdf http://irep.iium.edu.my/74563/2/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine_MYRA.pdf http://irep.iium.edu.my/74563/3/74563_IgE-mediated%20hypersensitivity%20to%20chlorhexidine_SCOPUS.pdf |