Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats
Piper sarmentosum is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb’s antihypertensive property. However, the exact mechanisms involved are still in question. The present...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English English English |
| Published: |
Hindawi
2019
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/74326/ http://irep.iium.edu.my/74326/2/Piper%20sarmentosum%20leaves%20aqueos.pdf http://irep.iium.edu.my/74326/8/74326_Piper%20sarmentosum%20Leaves%20Aqueous%20Extract%20Attenuates%20Vascular%20Endothelial%20Dysfunction%20in%20Spontaneously%20Hypertensive%20Rats_Scopus.pdf http://irep.iium.edu.my/74326/14/74326_Piper%20sarmentosum%20Leaves%20Aqueous%20Extract_wos.pdf |
| _version_ | 1848787948627034112 |
|---|---|
| author | Hashim Fauzy, Fatimatuzzahra Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah F T Elshami, Taher |
| author_facet | Hashim Fauzy, Fatimatuzzahra Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah F T Elshami, Taher |
| author_sort | Hashim Fauzy, Fatimatuzzahra |
| building | IIUM Repository |
| collection | Online Access |
| description | Piper sarmentosum is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb’s antihypertensive property. However, the exact mechanisms involved are still in question. The present study investigated the effects of Piper sarmentosum leaves aqueous extract (PSAE) treatment on vascular endothelin system in spontaneously hypertensive rats (SHRs). Four groups of SHRs were treated for 28 consecutive days, with negative and positive control groups receiving distilled water and 3 mg/kg perindopril, respectively. Another two groups are the treatment groups, which received PSAE and combination of 1.5 mg/kg perindopril and PSAE. Weekly measurements of blood pressure showed that PSAE significantly reduced the systolic, diastolic, and mean arterial pressures () of the rats. PSAE also increased mesenteric artery nitric oxide (NO) level () and reduced endothelin-1 (ET-1) level () in the treatment groups. Our results demonstrate that oral administration of PSAE reduced blood pressure in SHRs by reducing the ET-1 level while increasing NO production. |
| first_indexed | 2025-11-14T17:33:03Z |
| format | Article |
| id | iium-74326 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:33:03Z |
| publishDate | 2019 |
| publisher | Hindawi |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-743262020-04-05T22:15:11Z http://irep.iium.edu.my/74326/ Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats Hashim Fauzy, Fatimatuzzahra Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah F T Elshami, Taher R Medicine (General) Piper sarmentosum is a tropical plant in Southeast Asia known for its traditional use in curing various ailments including hypertension. Previous research works have provided evidence for the herb’s antihypertensive property. However, the exact mechanisms involved are still in question. The present study investigated the effects of Piper sarmentosum leaves aqueous extract (PSAE) treatment on vascular endothelin system in spontaneously hypertensive rats (SHRs). Four groups of SHRs were treated for 28 consecutive days, with negative and positive control groups receiving distilled water and 3 mg/kg perindopril, respectively. Another two groups are the treatment groups, which received PSAE and combination of 1.5 mg/kg perindopril and PSAE. Weekly measurements of blood pressure showed that PSAE significantly reduced the systolic, diastolic, and mean arterial pressures () of the rats. PSAE also increased mesenteric artery nitric oxide (NO) level () and reduced endothelin-1 (ET-1) level () in the treatment groups. Our results demonstrate that oral administration of PSAE reduced blood pressure in SHRs by reducing the ET-1 level while increasing NO production. Hindawi 2019-08-14 Article PeerReviewed application/pdf en http://irep.iium.edu.my/74326/2/Piper%20sarmentosum%20leaves%20aqueos.pdf application/pdf en http://irep.iium.edu.my/74326/8/74326_Piper%20sarmentosum%20Leaves%20Aqueous%20Extract%20Attenuates%20Vascular%20Endothelial%20Dysfunction%20in%20Spontaneously%20Hypertensive%20Rats_Scopus.pdf application/pdf en http://irep.iium.edu.my/74326/14/74326_Piper%20sarmentosum%20Leaves%20Aqueous%20Extract_wos.pdf Hashim Fauzy, Fatimatuzzahra and Mohd Zainudin, Maizura and Ismawi, Hidayatul Radziah and F T Elshami, Taher (2019) Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats. Evidence-Based Complementary and Alternative Medicine, Volume 2019. pp. 1-8. ISSN 1741-427X E-ISSN 1741-4288 https://www.hindawi.com/journals/ecam/2019/7198592/ https://doi.org/10.1155/2019/7198592 |
| spellingShingle | R Medicine (General) Hashim Fauzy, Fatimatuzzahra Mohd Zainudin, Maizura Ismawi, Hidayatul Radziah F T Elshami, Taher Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats |
| title | Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats |
| title_full | Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats |
| title_fullStr | Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats |
| title_full_unstemmed | Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats |
| title_short | Piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats |
| title_sort | piper sarmentosum leaves aqueous extract attenuates vascular endothelial dysfunction in spontaneously hypertensive rats |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/74326/ http://irep.iium.edu.my/74326/ http://irep.iium.edu.my/74326/ http://irep.iium.edu.my/74326/2/Piper%20sarmentosum%20leaves%20aqueos.pdf http://irep.iium.edu.my/74326/8/74326_Piper%20sarmentosum%20Leaves%20Aqueous%20Extract%20Attenuates%20Vascular%20Endothelial%20Dysfunction%20in%20Spontaneously%20Hypertensive%20Rats_Scopus.pdf http://irep.iium.edu.my/74326/14/74326_Piper%20sarmentosum%20Leaves%20Aqueous%20Extract_wos.pdf |