Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines
Kaempferia galanga is one of the herbal plant that have many medicinal properties. The plant extract has also been reported to possess in vitro anti-cancer activities on various cancer cell lines such as human colon cancer SW620, cervical cancer C33A, and breast cancer MCF-7 cell lines. Ethyl-p-meth...
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| Format: | Proceeding Paper |
| Language: | English English |
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Elsevier
2019
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| Online Access: | http://irep.iium.edu.my/74084/ http://irep.iium.edu.my/74084/7/74084%20Anti-neoplastic%20potential%20of%20ethyl-p-methoxycinnamate%20of.pdf http://irep.iium.edu.my/74084/13/74084_Anti-neoplastic%20potential%20of%20ethyl-p-methoxycinnamate%20of%20Kaempferia%20galanga%20on%20oral%20cancer%20cell%20lines_Scopus.pdf |
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| author | Ichwan, Solachuddin J. A. Husin, Atiyah Suriyah, Wastuti Hidayati Lestari, Widya Omar, Muhammad Nor Kasmuri, Abdul Razak |
| author_facet | Ichwan, Solachuddin J. A. Husin, Atiyah Suriyah, Wastuti Hidayati Lestari, Widya Omar, Muhammad Nor Kasmuri, Abdul Razak |
| author_sort | Ichwan, Solachuddin J. A. |
| building | IIUM Repository |
| collection | Online Access |
| description | Kaempferia galanga is one of the herbal plant that have many medicinal properties. The plant extract has also been reported to possess in vitro anti-cancer activities on various cancer cell lines such as human colon cancer SW620, cervical cancer C33A, and breast cancer MCF-7 cell lines. Ethyl-p-methoxycinnamate (EPMC), a major constituent of volatile oil of Kaempferia galanga has been attributed to its medicinal benefits. We report here for the first time the anticancer potential of EPMC on oral cancer cells derived from human oral cavity, HSC-3 and Ca922 lines. MTT assay results showed that EPMC markedly induced cytotoxicity on HSC-3 (IC50 0.075 mg/mL) and Ca922 (IC50 0.085 mg/mL) cell lines. The apoptotic activity induced by EPMC was detected in both cell lines by flow cytometry and confirmed with Caspase 3/7 assay. Moreover, quantitative RT-PCR analysis revealed that EPMC-induced apoptosis in both lines elevated the mRNA levels of pro-apoptotic genes caspase-9 and PUMA. These results suggest that EPMC may be a potential candidate for oral cancer treatment. |
| first_indexed | 2025-11-14T17:32:23Z |
| format | Proceeding Paper |
| id | iium-74084 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:32:23Z |
| publishDate | 2019 |
| publisher | Elsevier |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-740842019-11-26T08:15:37Z http://irep.iium.edu.my/74084/ Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines Ichwan, Solachuddin J. A. Husin, Atiyah Suriyah, Wastuti Hidayati Lestari, Widya Omar, Muhammad Nor Kasmuri, Abdul Razak RK Dentistry RM Therapeutics. Pharmacology Kaempferia galanga is one of the herbal plant that have many medicinal properties. The plant extract has also been reported to possess in vitro anti-cancer activities on various cancer cell lines such as human colon cancer SW620, cervical cancer C33A, and breast cancer MCF-7 cell lines. Ethyl-p-methoxycinnamate (EPMC), a major constituent of volatile oil of Kaempferia galanga has been attributed to its medicinal benefits. We report here for the first time the anticancer potential of EPMC on oral cancer cells derived from human oral cavity, HSC-3 and Ca922 lines. MTT assay results showed that EPMC markedly induced cytotoxicity on HSC-3 (IC50 0.075 mg/mL) and Ca922 (IC50 0.085 mg/mL) cell lines. The apoptotic activity induced by EPMC was detected in both cell lines by flow cytometry and confirmed with Caspase 3/7 assay. Moreover, quantitative RT-PCR analysis revealed that EPMC-induced apoptosis in both lines elevated the mRNA levels of pro-apoptotic genes caspase-9 and PUMA. These results suggest that EPMC may be a potential candidate for oral cancer treatment. Elsevier 2019 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/74084/7/74084%20Anti-neoplastic%20potential%20of%20ethyl-p-methoxycinnamate%20of.pdf application/pdf en http://irep.iium.edu.my/74084/13/74084_Anti-neoplastic%20potential%20of%20ethyl-p-methoxycinnamate%20of%20Kaempferia%20galanga%20on%20oral%20cancer%20cell%20lines_Scopus.pdf Ichwan, Solachuddin J. A. and Husin, Atiyah and Suriyah, Wastuti Hidayati and Lestari, Widya and Omar, Muhammad Nor and Kasmuri, Abdul Razak (2019) Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines. In: Conference on BioMedical and Advanced Materials (Bio-CAM 2017), 28-29th November 2017, Pulau Langkawi, Kedah. https://www.sciencedirect.com/science/article/pii/S221478531931449X 10.1016/j.matpr.2019.06.100 |
| spellingShingle | RK Dentistry RM Therapeutics. Pharmacology Ichwan, Solachuddin J. A. Husin, Atiyah Suriyah, Wastuti Hidayati Lestari, Widya Omar, Muhammad Nor Kasmuri, Abdul Razak Anti-neoplastic potential of ethyl-p-methoxycinnamate of Kaempferia galanga on oral cancer cell lines |
| title | Anti-neoplastic potential of ethyl-p-methoxycinnamate of
Kaempferia galanga on oral cancer cell lines |
| title_full | Anti-neoplastic potential of ethyl-p-methoxycinnamate of
Kaempferia galanga on oral cancer cell lines |
| title_fullStr | Anti-neoplastic potential of ethyl-p-methoxycinnamate of
Kaempferia galanga on oral cancer cell lines |
| title_full_unstemmed | Anti-neoplastic potential of ethyl-p-methoxycinnamate of
Kaempferia galanga on oral cancer cell lines |
| title_short | Anti-neoplastic potential of ethyl-p-methoxycinnamate of
Kaempferia galanga on oral cancer cell lines |
| title_sort | anti-neoplastic potential of ethyl-p-methoxycinnamate of
kaempferia galanga on oral cancer cell lines |
| topic | RK Dentistry RM Therapeutics. Pharmacology |
| url | http://irep.iium.edu.my/74084/ http://irep.iium.edu.my/74084/ http://irep.iium.edu.my/74084/ http://irep.iium.edu.my/74084/7/74084%20Anti-neoplastic%20potential%20of%20ethyl-p-methoxycinnamate%20of.pdf http://irep.iium.edu.my/74084/13/74084_Anti-neoplastic%20potential%20of%20ethyl-p-methoxycinnamate%20of%20Kaempferia%20galanga%20on%20oral%20cancer%20cell%20lines_Scopus.pdf |