Psychosocial distress and blood pressure among young adults: role of cortisol as mediator
Introduction: Hypertension is the most prevalent risk factor of cardiovascular diseases in Malaysia. 17.3% of hypertension cases in Malaysia is attributed to adults aged 18 to 39 years. Psychosocial distress is a possible risk factor for elevated blood pressure in young adults, and cortisol could...
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| Format: | Article |
| Language: | English English English |
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Kulliyyah of Medicine, International Islamic University Malaysia
2019
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| Online Access: | http://irep.iium.edu.my/74078/ http://irep.iium.edu.my/74078/1/74078_Psychosocial%20distress%20and%20blood%20pressure%20among%20young%20adults.pdf http://irep.iium.edu.my/74078/2/74078_Psychosocial%20distress%20and%20blood%20pressure%20among%20young%20adults_SCOPUS.pdf http://irep.iium.edu.my/74078/13/74078_Psychosocial%20distress%20and%20blood%20pressure_WOS.pdf |
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| author | Wan Omar, Wan Fatein Nabeila Mohd Shah, Azarisman Shah Ab Rahman, Jamalludin A.Talib, Norlelawati Musa, Ramli Mohd. Shah, Aida Nur Sharini Aung, Sithu Abdullah, Aszrin |
| author_facet | Wan Omar, Wan Fatein Nabeila Mohd Shah, Azarisman Shah Ab Rahman, Jamalludin A.Talib, Norlelawati Musa, Ramli Mohd. Shah, Aida Nur Sharini Aung, Sithu Abdullah, Aszrin |
| author_sort | Wan Omar, Wan Fatein Nabeila |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: Hypertension is the most prevalent risk factor of cardiovascular diseases in Malaysia.
17.3% of hypertension cases in Malaysia is attributed to adults aged 18 to 39 years. Psychosocial distress is a
possible risk factor for elevated blood pressure in young adults, and cortisol could be the mediating factor.
The aim of this study is to evaluate the mediating role of cortisol in hypertension and psychosocial distress
in young adults. Methods and materials: A comparative cross-sectional study was conducted in 240 young
adults aged 18 to 45 years. The body mass index, waist circumference and blood pressure parameters were
recorded. Serum cortisol, creatinine, fasting blood glucose and lipid profile were measured following acute
mental stress test. Psychosocial distress was assessed using the DASS-21 questionnaire. Results: Mean
(standard deviation) values for SBP, DBP, MAP were 126.0(16.3), 84.1(12.2) and 98.1(13.1) mmHg
respectively. Anxiety was significantly associated with systolic blood pressure (β=0.644), diastolic blood
pressure (β=0.454) and mean arterial pressure (β=0.516) after adjusting for sex, age and cortisol. However,
it was not mediated by cortisol. Depression and stress were not found to have any effect on blood pressure
of the young adults studied. Conclusion: The data suggest that there is no elevated risk for psychosocial
distress and hypertension that cortisol poses in young adults. |
| first_indexed | 2025-11-14T17:32:22Z |
| format | Article |
| id | iium-74078 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:32:22Z |
| publishDate | 2019 |
| publisher | Kulliyyah of Medicine, International Islamic University Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-740782021-01-29T03:00:34Z http://irep.iium.edu.my/74078/ Psychosocial distress and blood pressure among young adults: role of cortisol as mediator Wan Omar, Wan Fatein Nabeila Mohd Shah, Azarisman Shah Ab Rahman, Jamalludin A.Talib, Norlelawati Musa, Ramli Mohd. Shah, Aida Nur Sharini Aung, Sithu Abdullah, Aszrin RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Introduction: Hypertension is the most prevalent risk factor of cardiovascular diseases in Malaysia. 17.3% of hypertension cases in Malaysia is attributed to adults aged 18 to 39 years. Psychosocial distress is a possible risk factor for elevated blood pressure in young adults, and cortisol could be the mediating factor. The aim of this study is to evaluate the mediating role of cortisol in hypertension and psychosocial distress in young adults. Methods and materials: A comparative cross-sectional study was conducted in 240 young adults aged 18 to 45 years. The body mass index, waist circumference and blood pressure parameters were recorded. Serum cortisol, creatinine, fasting blood glucose and lipid profile were measured following acute mental stress test. Psychosocial distress was assessed using the DASS-21 questionnaire. Results: Mean (standard deviation) values for SBP, DBP, MAP were 126.0(16.3), 84.1(12.2) and 98.1(13.1) mmHg respectively. Anxiety was significantly associated with systolic blood pressure (β=0.644), diastolic blood pressure (β=0.454) and mean arterial pressure (β=0.516) after adjusting for sex, age and cortisol. However, it was not mediated by cortisol. Depression and stress were not found to have any effect on blood pressure of the young adults studied. Conclusion: The data suggest that there is no elevated risk for psychosocial distress and hypertension that cortisol poses in young adults. Kulliyyah of Medicine, International Islamic University Malaysia 2019-08-06 Article PeerReviewed application/pdf en http://irep.iium.edu.my/74078/1/74078_Psychosocial%20distress%20and%20blood%20pressure%20among%20young%20adults.pdf application/pdf en http://irep.iium.edu.my/74078/2/74078_Psychosocial%20distress%20and%20blood%20pressure%20among%20young%20adults_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/74078/13/74078_Psychosocial%20distress%20and%20blood%20pressure_WOS.pdf Wan Omar, Wan Fatein Nabeila and Mohd Shah, Azarisman Shah and Ab Rahman, Jamalludin and A.Talib, Norlelawati and Musa, Ramli and Mohd. Shah, Aida Nur Sharini and Aung, Sithu and Abdullah, Aszrin (2019) Psychosocial distress and blood pressure among young adults: role of cortisol as mediator. International Medical Journal Malaysia, 18 (2). pp. 69-75. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_18_no_2/Pages-from-IMJMVol18No2-12.pdf |
| spellingShingle | RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System Wan Omar, Wan Fatein Nabeila Mohd Shah, Azarisman Shah Ab Rahman, Jamalludin A.Talib, Norlelawati Musa, Ramli Mohd. Shah, Aida Nur Sharini Aung, Sithu Abdullah, Aszrin Psychosocial distress and blood pressure among young adults: role of cortisol as mediator |
| title | Psychosocial distress and blood pressure among young adults: role of cortisol as mediator |
| title_full | Psychosocial distress and blood pressure among young adults: role of cortisol as mediator |
| title_fullStr | Psychosocial distress and blood pressure among young adults: role of cortisol as mediator |
| title_full_unstemmed | Psychosocial distress and blood pressure among young adults: role of cortisol as mediator |
| title_short | Psychosocial distress and blood pressure among young adults: role of cortisol as mediator |
| title_sort | psychosocial distress and blood pressure among young adults: role of cortisol as mediator |
| topic | RC321 Neuroscience. Biological psychiatry. Neuropsychiatry RC667 Specialties of Internal Medicine-Diseases of Circulatory (Cardiovascular) System |
| url | http://irep.iium.edu.my/74078/ http://irep.iium.edu.my/74078/ http://irep.iium.edu.my/74078/1/74078_Psychosocial%20distress%20and%20blood%20pressure%20among%20young%20adults.pdf http://irep.iium.edu.my/74078/2/74078_Psychosocial%20distress%20and%20blood%20pressure%20among%20young%20adults_SCOPUS.pdf http://irep.iium.edu.my/74078/13/74078_Psychosocial%20distress%20and%20blood%20pressure_WOS.pdf |