Inflammatory response of bioscaffolds decellularized by sonication treatment
Decellularization of sonication system efficiency is dictated by evaluation of host immune response on scaffolds. This aim of this study is to examine the inflammatory response after implantation of bioscaffolds decellularized by sonication treatment at 35 days postsurgery in rats. In this study,...
| Main Authors: | , , |
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
Springer
2018
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| Online Access: | http://irep.iium.edu.my/72879/ http://irep.iium.edu.my/72879/14/72879%20Inflammatory%20Response.pdf http://irep.iium.edu.my/72879/2/72879%20Inflammatory%20Response%20of%20Bioscaffolds%20Decellularized%20SCOPUS.pdf |
| _version_ | 1848787698773393408 |
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| author | Hazwani, Aqilah Sha'ban, Munirah Azhim, Azran |
| author_facet | Hazwani, Aqilah Sha'ban, Munirah Azhim, Azran |
| author_sort | Hazwani, Aqilah |
| building | IIUM Repository |
| collection | Online Access |
| description | Decellularization of sonication system efficiency is dictated by evaluation of host immune
response on scaffolds. This aim of this study is to examine the inflammatory response
after implantation of bioscaffolds decellularized by sonication treatment at 35 days postsurgery in rats. In this study, aortic tissues decellularized by sonication treatment in 0.1
and 2% of Sodium Dodecyl Sulfate (SDS) detergents. Samples were washed for 5 days in
Phosphate Buffer Saline (PBS) following decellularization. Samples were implanted in on
the lower right thoracic cavity of rats for 35 days. To examine the inflammatory response,
the implanted samples were explanted and evaluated histologically by Hematoxylin
Eosin (H-E) staining. From the histological analysis, bioscaffolds decellularized by
sonication treatment in response to macrophages shows the minimal inflammatory
response. Minimal inflammatory response elicits by bioscaffolds suggests the safety of
bioscaffolds prepared by sonication treatment as biomedical implants. |
| first_indexed | 2025-11-14T17:29:04Z |
| format | Proceeding Paper |
| id | iium-72879 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:29:04Z |
| publishDate | 2018 |
| publisher | Springer |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-728792019-07-03T07:32:42Z http://irep.iium.edu.my/72879/ Inflammatory response of bioscaffolds decellularized by sonication treatment Hazwani, Aqilah Sha'ban, Munirah Azhim, Azran R Medicine (General) Decellularization of sonication system efficiency is dictated by evaluation of host immune response on scaffolds. This aim of this study is to examine the inflammatory response after implantation of bioscaffolds decellularized by sonication treatment at 35 days postsurgery in rats. In this study, aortic tissues decellularized by sonication treatment in 0.1 and 2% of Sodium Dodecyl Sulfate (SDS) detergents. Samples were washed for 5 days in Phosphate Buffer Saline (PBS) following decellularization. Samples were implanted in on the lower right thoracic cavity of rats for 35 days. To examine the inflammatory response, the implanted samples were explanted and evaluated histologically by Hematoxylin Eosin (H-E) staining. From the histological analysis, bioscaffolds decellularized by sonication treatment in response to macrophages shows the minimal inflammatory response. Minimal inflammatory response elicits by bioscaffolds suggests the safety of bioscaffolds prepared by sonication treatment as biomedical implants. Springer 2018 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/72879/14/72879%20Inflammatory%20Response.pdf application/pdf en http://irep.iium.edu.my/72879/2/72879%20Inflammatory%20Response%20of%20Bioscaffolds%20Decellularized%20SCOPUS.pdf Hazwani, Aqilah and Sha'ban, Munirah and Azhim, Azran (2018) Inflammatory response of bioscaffolds decellularized by sonication treatment. In: 2nd International Conference for Innovation in Biomedical Engineering and Life Sciences ICIBEL 2017 (in conjunction with APCMBE 2017), 10th–13th December 2017, Penang, Malaysia. https://link.springer.com/chapter/10.1007/978-981-10-7554-4_32 10.1007/978-981-10-7554-4_32 |
| spellingShingle | R Medicine (General) Hazwani, Aqilah Sha'ban, Munirah Azhim, Azran Inflammatory response of bioscaffolds decellularized by sonication treatment |
| title | Inflammatory response of bioscaffolds decellularized by sonication treatment |
| title_full | Inflammatory response of bioscaffolds decellularized by sonication treatment |
| title_fullStr | Inflammatory response of bioscaffolds decellularized by sonication treatment |
| title_full_unstemmed | Inflammatory response of bioscaffolds decellularized by sonication treatment |
| title_short | Inflammatory response of bioscaffolds decellularized by sonication treatment |
| title_sort | inflammatory response of bioscaffolds decellularized by sonication treatment |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/72879/ http://irep.iium.edu.my/72879/ http://irep.iium.edu.my/72879/ http://irep.iium.edu.my/72879/14/72879%20Inflammatory%20Response.pdf http://irep.iium.edu.my/72879/2/72879%20Inflammatory%20Response%20of%20Bioscaffolds%20Decellularized%20SCOPUS.pdf |