Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study

QR Code

Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study

We have synthesized quinoxaline analogs (1–25), characterized by 1H-NMR and HREI-MS and evaluated for thymidine phosphorylase inhibition. Among the series, nineteen analogs showed better inhibition when compared with the standard inhibitor 7-Deazaxanthine (IC50 = 38.68 ± 4.42 µM). The most potent...

Full description

Bibliographic Details
Main Authors:	Noor Barak, Almandil, Taha, Muhammad, Farooq, Rai Khalid, Alhibshi, Amani, Ibrahim, Mohamed, Anouar, El Hassane, Gollapalli, Mohammed, Rahim, Fazal, Nawaz, Muhammad, ,, Syed Adnan Ali Shah, Ahmed, Qamar Uddin, Zakaria, Zainul Amiruddin
Format:	Article
Language:	English English English
Published:	MDPI 2019
Subjects:	RS Pharmacy and materia medica
Online Access:	http://irep.iium.edu.my/72692/ http://irep.iium.edu.my/72692/1/72692%20Synthesis%20of%20Thymidine%20Phosphorylase.pdf http://irep.iium.edu.my/72692/2/72692%20Synthesis%20of%20Thymidine%20Phosphorylase%20SCOPUS.pdf http://irep.iium.edu.my/72692/13/72692_Synthesis%20of%20Thymidine%20Phosphorylase%20Inhibitor%20Based%20on%20Quinoxaline%20Derivatives%20and%20Their%20Molecular%20Docking%20Study_wos.pdf

Similar Items

Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study
by: Almandil, Noor Barak, et al.
Published: (2019)

Synthesis of new isoquinoline-base-oxadiazole derivatives as potent inhibitors of thymidine phosphorylase and molecular docking study
by: Zaman, Khalid, et al.
Published: (2019)

Synthesis and in vitro evaluation of 1,2,4-triazolo[1,5-a][1,3,5]triazine derivatives as thymidine phosphorylase inhibitors
by: Bera, H., et al.
Published: (2013)

Fragment-based approach to the design of 5-chlorouracil-linked-pyrazolo[1, 5-a][1,3,5]triazines as thymidine phosphorylase inhibitors
by: Sun, L., et al.
Published: (2013)

Synthesis, anti-thymidine phosphorylase activity and molecular docking of 5-thioxo-[1,2,4]triazolo[1,5-a][1,3,5]triazin-7-ones
by: Bera, H., et al.
Published: (2013)

Discovery of mixed type thymidine phosphorylase inhibitors endowed with antiangiogenic properties: Synthesis, pharmacological evaluation and molecular docking study of 2-thioxo-pyrazolo[1,5-a][1,3,5]triazin-4-ones. Part II
by: Bera, H., et al.
Published: (2014)

Synthesis And Molecular Docking Studies Of New Phenylisoxazole Quinoxaline-2-Amine Hybrids As Potential Α Amylase And Α-Glucosidase Inhibitors
by: Radzuan, Siti Nurshahira Mohd
Published: (2024)

Synthesis, in vitro evaluation of thymidine phosphorylase inhibitory activity, and in silico study of 1,3,5-triazin-2,4-dione and its fused analogues
by: Bera, H., et al.
Published: (2013)

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy
by: Soong, R., et al.
Published: (2008)

Synthesis, Characterisation And Molecular Docking Of Quinoxaline-isoxazole Hybrids As Potential Anti-hyperglycemic Agent
by: Phongphane, Lacksany
Published: (2024)

Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
by: Taha, Muhammad, et al.
Published: (2019)

Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors
by: Taha, Muhammad, et al.
Published: (2019)

Analysis of Nucleoside Phosphorylase Polymorphism in Capra Hircus
by: Sekaran, M., et al.
Published: (1989)

A structure-activity relationship study of 1,2,4-triazolo[1,5-a][1,3,5] triazin-5,7-dione and its 5-thioxo analogues on anti-thymidine phosphorylase and associated anti-angiogenic activities
by: Bera, H., et al.
Published: (2013)

Synthesis of quinoxaline derivatives and their antibacterial activity against pathogenic bacteria
by: Khatoon, Hena
Published: (2023)

A focussed analysis of β-cyclodextrins for quinoxaline derivatives synthesis
by: Khatoon, Hena, et al.
Published: (2024)

Optimizing reaction efficiency: microwave-supported synthesis of quinoxaline-based compounds
by: Khatoon, Hena, et al.
Published: (2024)

Synthesis and molecular docking of carvone derivatives as a potential neuraminidase inhibitors
by: Jusoh, Noorakmar, et al.
Published: (2016)

Molecular docking analysis of curcumin analogues as human neutrophil elastase inhibitors
by: Narayanaswamy, Radhakrishnan, et al.
Published: (2014)

Investigation of α-glucosidase inhibitory metabolites from Tetracera scandens leaves by GC–MS metabolite profiling and docking studies
by: Nokhala, Ahmed, et al.
Published: (2020)

Synthesis of a series of quinoxaline derivatives and their antibacterial effectiveness against pathogenic bacteria
by: Khatoon, Hena, et al.
Published: (2024)

Exploring quinoxaline derivatives: An overview of a new approach to combat antimicrobial resistance
by: Khatoon, Hena, et al.
Published: (2024)

Molecular docking unveils prospective inhibitors for the SARS-COV-2 main protease
by: Ahmad, Fawad, et al.
Published: (2021)

Investigation of α‐glucosidase inhibitory metabolites from Tetracera scandens leaves by GC–MS metabolite profiling and docking studies
by: Ahmed, Nokhala, et al.
Published: (2020)

Soluble glutamic-pyruvic transaminase,esterase D.,nucleoside phosphorylase and placenta acid phosphatase in Malaysia.
by: Tan, Soon Guan, et al.
Published: (1977)

Effective synthesis of quinoxalines over ceria based solid acids coated on honeycomb monoliths
by: Venkatesh, et al.
Published: (2015)

Effective synthesis of quinoxalines over ceria based solid acids coated on honeycomb monoliths
by: Venkatesh, et al.
Published: (2015)

Molecular docking studies of selected medicinal drugs as dengue virus-2 protease inhibitors
by: Rufaidah Othman,, et al.
Published: (2017)

Synthesis, characterization and molecular docking of hydroxyxanthone and renylated xanthone derivatives as potential aromatase inhibitor
by: Ramakrishnan, Shurutishria
Published: (2022)

2-acetylthiophene thiosemicarbazone as mushroom tyrosinase inhibitor: insights from kinetic, RDG, molecular docking, and DFT studies
by: Ahmad, Mohammad Norazmi, et al.
Published: (2019)

Molecular docking of selected flavonoid compounds from nelumbo nucifera as potential pancreatic lipase inhibitor
by: Ghazali, Siti Nur Akmal, et al.
Published: (2017)

Computational quest for finding potential Ebola VP40 inhibitors: a molecular docking study
by: Mohamad Ariff Mohamad Yussoff,, et al.
Published: (2020)

Identification of Inhibitor Binding Site in Human Sirtuin 2 Using Molecular Docking and Dynamics Simulations
by: Sakkiah, Sugunadevi, et al.
Published: (2013)

Identification of novel 5-lipoxygenase-activating protein (FLAP) inhibitors by an integrated method of pharmacophore virtual screening, docking, QSAR and ADMET analyses
by: Rullah, Kamal, et al.
Published: (2023)

Synthetic approaches to 2-substituted pyrazines and 2-substituted quinoxalines and their fluorescence characteristics / Azila Mohd Idris
by: Mohd Idris, Azila
Published: (2009)

Recent progress in benzimidazole and quinoxaline dyes based on dye-sensitized solar cell: a comprehensive overview
by: Nassar, Maadh F., et al.
Published: (2023)

Synthesis and docking studies of 2,4,6-trihydroxy-3-geranylacetophenone analogs as potential lipoxygenase inhibitor
by: Chean, Hui Ng, et al.
Published: (2014)

Molecular docking and structure-activity relationship studies on benzothiazole based non-peptidic BACE-1 inhibitors
by: Xu, W., et al.
Published: (2010)

Studies of the benzopyran class of selective COX-2 inhibitors using 3D-QSAR and molecular docking
by: Yadav, D., et al.
Published: (2017)

3D-QSAR studies of checkpoint kinase 1 inhibitors based on molecular docking and CoMFA
by: Wang, R., et al.
Published: (2010)