In vitro evaluation of the effect of Pluchea indica extracts in promoting glucose consumption activity on a liver cell line
Background: Type 2 diabetes mellitus is a chronic metabolic disorder that is associated with mortality and morbidity. Recently, several plant-based agents have been used in the management of diabetes. Pluchea indica has been traditionally consumed as a medicinal plant in Southeast Asia, and its leav...
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Universitas Indonesia
2019
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| Online Access: | http://irep.iium.edu.my/71834/ http://irep.iium.edu.my/71834/1/71834_In%20vitro%20Evaluation%20of%20the%20Effect%20of%20Pluchea.pdf http://irep.iium.edu.my/71834/7/71834_In%20vitro%20Evaluation%20of%20the%20Effect%20of%20Pluchea%20indica%20Extracts%20in%20Promoting%20Glucose%20Consumption%20Activity%20on%20A%20Liver%20Cell%20Line_WOS.pdf |
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| author | Suriyah, Wastuti Hidayati Ichwan, Solachuddin J. A. Kasmuri, Abdul Razak Taher, Muhammad |
| author_facet | Suriyah, Wastuti Hidayati Ichwan, Solachuddin J. A. Kasmuri, Abdul Razak Taher, Muhammad |
| author_sort | Suriyah, Wastuti Hidayati |
| building | IIUM Repository |
| collection | Online Access |
| description | Background: Type 2 diabetes mellitus is a chronic metabolic disorder that is associated with mortality and morbidity. Recently, several plant-based agents have been used in the management of diabetes. Pluchea indica has been traditionally consumed as a medicinal plant in Southeast Asia, and its leaves have demonstrated induction of hypoglycemic effect in normal rats. This in vitro study aimed to evaluate the potency of P. indica extracts in stimulating glucose consumption in human liver CCL-13 cell line model. Methods: P. indica leaves were dried and extracted using a series of organic solvents and water. The effect of the extracts on cell viability was determined by MTT assay. The glucose consumption was analyzed using glucose oxidase method. Results: Our results revealed that the methanol extract of P. indica could significantly increase glucose consumption of cells in a concentration-dependent manner, which suggests the usefulness of the extract as an antidiabetic candidate via stimulation of glucose uptake into the liver cells. Conclusion: Our study suggests that P. indica is a potential natural candidate for diabetes mellitus management. |
| first_indexed | 2025-11-14T17:26:11Z |
| format | Article |
| id | iium-71834 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:26:11Z |
| publishDate | 2019 |
| publisher | Universitas Indonesia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-718342019-07-31T07:53:04Z http://irep.iium.edu.my/71834/ In vitro evaluation of the effect of Pluchea indica extracts in promoting glucose consumption activity on a liver cell line Suriyah, Wastuti Hidayati Ichwan, Solachuddin J. A. Kasmuri, Abdul Razak Taher, Muhammad RM Therapeutics. Pharmacology RM300 Drugs and their action Background: Type 2 diabetes mellitus is a chronic metabolic disorder that is associated with mortality and morbidity. Recently, several plant-based agents have been used in the management of diabetes. Pluchea indica has been traditionally consumed as a medicinal plant in Southeast Asia, and its leaves have demonstrated induction of hypoglycemic effect in normal rats. This in vitro study aimed to evaluate the potency of P. indica extracts in stimulating glucose consumption in human liver CCL-13 cell line model. Methods: P. indica leaves were dried and extracted using a series of organic solvents and water. The effect of the extracts on cell viability was determined by MTT assay. The glucose consumption was analyzed using glucose oxidase method. Results: Our results revealed that the methanol extract of P. indica could significantly increase glucose consumption of cells in a concentration-dependent manner, which suggests the usefulness of the extract as an antidiabetic candidate via stimulation of glucose uptake into the liver cells. Conclusion: Our study suggests that P. indica is a potential natural candidate for diabetes mellitus management. Universitas Indonesia 2019-04 Article PeerReviewed application/pdf en http://irep.iium.edu.my/71834/1/71834_In%20vitro%20Evaluation%20of%20the%20Effect%20of%20Pluchea.pdf application/pdf en http://irep.iium.edu.my/71834/7/71834_In%20vitro%20Evaluation%20of%20the%20Effect%20of%20Pluchea%20indica%20Extracts%20in%20Promoting%20Glucose%20Consumption%20Activity%20on%20A%20Liver%20Cell%20Line_WOS.pdf Suriyah, Wastuti Hidayati and Ichwan, Solachuddin J. A. and Kasmuri, Abdul Razak and Taher, Muhammad (2019) In vitro evaluation of the effect of Pluchea indica extracts in promoting glucose consumption activity on a liver cell line. Makara Journal of Health Research, 23 (1). pp. 48-52. ISSN 2356-3664 E-ISSN 2356-3656 http://journal.ui.ac.id/index.php/health/article/view/10153/pdf 10.7454/msk.v23i1.10153 |
| spellingShingle | RM Therapeutics. Pharmacology RM300 Drugs and their action Suriyah, Wastuti Hidayati Ichwan, Solachuddin J. A. Kasmuri, Abdul Razak Taher, Muhammad In vitro evaluation of the effect of Pluchea indica extracts in promoting glucose consumption activity on a liver cell line |
| title | In vitro evaluation of the effect of Pluchea indica extracts in promoting glucose consumption activity on a liver cell line |
| title_full | In vitro evaluation of the effect of Pluchea indica extracts in promoting glucose consumption activity on a liver cell line |
| title_fullStr | In vitro evaluation of the effect of Pluchea indica extracts in promoting glucose consumption activity on a liver cell line |
| title_full_unstemmed | In vitro evaluation of the effect of Pluchea indica extracts in promoting glucose consumption activity on a liver cell line |
| title_short | In vitro evaluation of the effect of Pluchea indica extracts in promoting glucose consumption activity on a liver cell line |
| title_sort | in vitro evaluation of the effect of pluchea indica extracts in promoting glucose consumption activity on a liver cell line |
| topic | RM Therapeutics. Pharmacology RM300 Drugs and their action |
| url | http://irep.iium.edu.my/71834/ http://irep.iium.edu.my/71834/ http://irep.iium.edu.my/71834/ http://irep.iium.edu.my/71834/1/71834_In%20vitro%20Evaluation%20of%20the%20Effect%20of%20Pluchea.pdf http://irep.iium.edu.my/71834/7/71834_In%20vitro%20Evaluation%20of%20the%20Effect%20of%20Pluchea%20indica%20Extracts%20in%20Promoting%20Glucose%20Consumption%20Activity%20on%20A%20Liver%20Cell%20Line_WOS.pdf |