Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy
Purpose: This study evaluated the risk of opioid dose escalation as it relates to sex differences among patients receiving opioids for long-term therapy. Patients and methods: This retrospective cohort study was conducted in tertiary hospital settings in Malaysia using electronic prescription rec...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English English English |
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Dove Press Ltd.
2019
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| Online Access: | http://irep.iium.edu.my/71531/ http://irep.iium.edu.my/71531/1/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation_article.pdf http://irep.iium.edu.my/71531/2/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation_scopus.pdf http://irep.iium.edu.my/71531/3/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation_wos.pdf |
| _version_ | 1848787465871032320 |
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| author | Zin, Che Suraya Alias, Nor Elina Mohd Taufek, Nor Hidayah Meor Ahmad, Mazlila |
| author_facet | Zin, Che Suraya Alias, Nor Elina Mohd Taufek, Nor Hidayah Meor Ahmad, Mazlila |
| author_sort | Zin, Che Suraya |
| building | IIUM Repository |
| collection | Online Access |
| description | Purpose: This study evaluated the risk of opioid dose escalation as it relates to sex differences among patients receiving opioids for long-term therapy.
Patients and methods: This retrospective cohort study was conducted in tertiary hospital settings in Malaysia using electronic prescription records. Opioid naïve patients, aged ≥ 18 years, who were undergoing long-term opioid therapy of ≥ 90 days, with at least one opioid prescription (buprenorphine, morphine, oxycodone, fentanyl, dihydrocodeine or tramadol) between 1st January 2011 and 31st December 2016, were included in the study. They were followed until (i) the end of the study period, (ii) death from any cause or (iii) discontinuation of therapy from their first opioid prescription without any intervals of ≥ 120 days between successive prescriptions. The risk of high opioid dose escalation to ≥ 100 mg/day and ≥ 200 mg/day relative to men and women was measured.
Results: A total of 4688 patients (58.8% women, 41.3% men) on long-term opioid therapy were identified. Among these patients, 248 (5.29%) were escalated to high opioid doses of ≥ 100 mg/day and 69 (1.47%) were escalated to ≥ 200 mg/day. The escalation to high-dose opioid therapy was more likely to occur in men than in women, even after adjustment for age (dose ≥ 100 mg/day [adjusted hazard ratio 2.32; 95% confidence interval (CI), 1.79 to 3.00; p < 0.0001] and ≥ 200 mg/day [adjusted hazard ratio 6.10; 95% CI, 3.39 to 10.98; p < 0.0001]).
Conclusion: The risk of opioid dose escalation differed between men and women, as men were at higher risk than women for high opioid dose escalation. |
| first_indexed | 2025-11-14T17:25:22Z |
| format | Article |
| id | iium-71531 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:25:22Z |
| publishDate | 2019 |
| publisher | Dove Press Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-715312020-04-10T05:29:18Z http://irep.iium.edu.my/71531/ Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy Zin, Che Suraya Alias, Nor Elina Mohd Taufek, Nor Hidayah Meor Ahmad, Mazlila RM Therapeutics. Pharmacology Purpose: This study evaluated the risk of opioid dose escalation as it relates to sex differences among patients receiving opioids for long-term therapy. Patients and methods: This retrospective cohort study was conducted in tertiary hospital settings in Malaysia using electronic prescription records. Opioid naïve patients, aged ≥ 18 years, who were undergoing long-term opioid therapy of ≥ 90 days, with at least one opioid prescription (buprenorphine, morphine, oxycodone, fentanyl, dihydrocodeine or tramadol) between 1st January 2011 and 31st December 2016, were included in the study. They were followed until (i) the end of the study period, (ii) death from any cause or (iii) discontinuation of therapy from their first opioid prescription without any intervals of ≥ 120 days between successive prescriptions. The risk of high opioid dose escalation to ≥ 100 mg/day and ≥ 200 mg/day relative to men and women was measured. Results: A total of 4688 patients (58.8% women, 41.3% men) on long-term opioid therapy were identified. Among these patients, 248 (5.29%) were escalated to high opioid doses of ≥ 100 mg/day and 69 (1.47%) were escalated to ≥ 200 mg/day. The escalation to high-dose opioid therapy was more likely to occur in men than in women, even after adjustment for age (dose ≥ 100 mg/day [adjusted hazard ratio 2.32; 95% confidence interval (CI), 1.79 to 3.00; p < 0.0001] and ≥ 200 mg/day [adjusted hazard ratio 6.10; 95% CI, 3.39 to 10.98; p < 0.0001]). Conclusion: The risk of opioid dose escalation differed between men and women, as men were at higher risk than women for high opioid dose escalation. Dove Press Ltd. 2019-03-26 Article PeerReviewed application/pdf en http://irep.iium.edu.my/71531/1/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation_article.pdf application/pdf en http://irep.iium.edu.my/71531/2/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation_scopus.pdf application/pdf en http://irep.iium.edu.my/71531/3/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation_wos.pdf Zin, Che Suraya and Alias, Nor Elina and Mohd Taufek, Nor Hidayah and Meor Ahmad, Mazlila (2019) Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy. Journal of Pain Research. pp. 1-21. ISSN 1178-7090 (In Press) https://www.dovepress.com/journal-of-pain-research-journal |
| spellingShingle | RM Therapeutics. Pharmacology Zin, Che Suraya Alias, Nor Elina Mohd Taufek, Nor Hidayah Meor Ahmad, Mazlila Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy |
| title | Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy |
| title_full | Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy |
| title_fullStr | Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy |
| title_full_unstemmed | Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy |
| title_short | Sex differences in high opioid dose escalation among Malaysian patients with long term opioid therapy |
| title_sort | sex differences in high opioid dose escalation among malaysian patients with long term opioid therapy |
| topic | RM Therapeutics. Pharmacology |
| url | http://irep.iium.edu.my/71531/ http://irep.iium.edu.my/71531/ http://irep.iium.edu.my/71531/1/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation_article.pdf http://irep.iium.edu.my/71531/2/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation_scopus.pdf http://irep.iium.edu.my/71531/3/71531_Sex%20differences%20in%20high%20opioid%20dose%20escalation_wos.pdf |