Dominant-negative effect of a missense variant in the TASK-2 (KCNK5) K+ channel associated with Balkan endemic nephropathy

Dominant-negative effect of a missense variant in the TASK-2 (KCNK5) K+ channel associated with Balkan endemic nephropathy

TASK-2, a member of the Two-Pore Domain (K2P) subfamily of K+ channels, is encoded by the KCNK5 gene. The channel is expressed primarily in renal epithelial tissues and a poten- tially deleterious missense variant in KCNK5 has recently been shown to be prevalent amongst patients predisposed to the d...

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Bibliographic Details
Main Authors: Reed, Alan, Bucci, Giovanna, Abd-Wahab, Firdaus, Tucker, Stephen J.
Format: Article
Language:English
Published: PLOS 2016
Subjects:
QP Physiology
Online Access:http://irep.iium.edu.my/71035/
http://irep.iium.edu.my/71035/1/journal.pone.0156456.PDF

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