Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo
Introduction: Derris trifoliata has been traditionally used as folk for the treatment of , rheumatic joints, diarrhoea, and dysmenorrhea, and rotenoids isolated from the plant have shown to exhibit anti-cancer properties. This study aimed to assess the toxicity effects and antiangiogenic activity of...
| Main Authors: | , |
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| Format: | Proceeding Paper |
| Language: | English English English English |
| Published: |
2018
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| Online Access: | http://irep.iium.edu.my/69896/ http://irep.iium.edu.my/69896/3/ISOPS12%20Ankara%20Turkiye%20%20oral%20DrWan%20Azizi%2027.06.2018.pdf http://irep.iium.edu.my/69896/9/ISOPS12-AbstractBook.pdf http://irep.iium.edu.my/69896/10/Acceptance%20Wan%20Mohd%20Azizi%20BIn%20Wan%20Sulaiman-ANTI-ANGIOGENIC%20AND%20TOXICITY%20EFFECTS.pdf http://irep.iium.edu.my/69896/11/Full%20Paper%20DrWan%20Azizi%20ISOPS%20Ankara%20Turkey%20June%202018.pdf |
| _version_ | 1848787195685502976 |
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| author | Wan Sulaiman, Wan Mohd. Azizi Unal, Kevser |
| author_facet | Wan Sulaiman, Wan Mohd. Azizi Unal, Kevser |
| author_sort | Wan Sulaiman, Wan Mohd. Azizi |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: Derris trifoliata has been traditionally used as folk for the treatment of , rheumatic joints, diarrhoea, and dysmenorrhea, and rotenoids isolated from the plant have shown to exhibit anti-cancer properties. This study aimed to assess the toxicity effects and antiangiogenic activity of extract of Derris trifoliata on zebrafish embryo model.
Materials and Methods: Zebrafihs embryos were treated with aqueous extract of Derris Trifoliata to evaluate its effects on angiogenesis and zebrafish-toxicity. Angiogenic response was analyzed using whole-mount alkaline phosphatase (AP) vessel staining on 72 hours post fertilization (hpf) zebrafish embryos.
Results: 1.0 mg/ml concentration was toxic to zebrafish embryos and embryos exposed to concentrations at 0.5 mg/ml and below showed some malformations. Derris trifoliata aqueous extract also showed some anti-angiogenic activity in vivo in the zebrafish embryo model wereby at high concentration inhibited vessel formation in zebrafish embryo.
Conclusions: The anti-angiogenic response of extract of Derris trifoliata in zebrafish in vivo model suggest its therapeutic potential as anti-cancer agent. |
| first_indexed | 2025-11-14T17:21:04Z |
| format | Proceeding Paper |
| id | iium-69896 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English English |
| last_indexed | 2025-11-14T17:21:04Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-698962019-01-24T07:39:07Z http://irep.iium.edu.my/69896/ Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo Wan Sulaiman, Wan Mohd. Azizi Unal, Kevser RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents Introduction: Derris trifoliata has been traditionally used as folk for the treatment of , rheumatic joints, diarrhoea, and dysmenorrhea, and rotenoids isolated from the plant have shown to exhibit anti-cancer properties. This study aimed to assess the toxicity effects and antiangiogenic activity of extract of Derris trifoliata on zebrafish embryo model. Materials and Methods: Zebrafihs embryos were treated with aqueous extract of Derris Trifoliata to evaluate its effects on angiogenesis and zebrafish-toxicity. Angiogenic response was analyzed using whole-mount alkaline phosphatase (AP) vessel staining on 72 hours post fertilization (hpf) zebrafish embryos. Results: 1.0 mg/ml concentration was toxic to zebrafish embryos and embryos exposed to concentrations at 0.5 mg/ml and below showed some malformations. Derris trifoliata aqueous extract also showed some anti-angiogenic activity in vivo in the zebrafish embryo model wereby at high concentration inhibited vessel formation in zebrafish embryo. Conclusions: The anti-angiogenic response of extract of Derris trifoliata in zebrafish in vivo model suggest its therapeutic potential as anti-cancer agent. 2018 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/69896/3/ISOPS12%20Ankara%20Turkiye%20%20oral%20DrWan%20Azizi%2027.06.2018.pdf application/pdf en http://irep.iium.edu.my/69896/9/ISOPS12-AbstractBook.pdf application/pdf en http://irep.iium.edu.my/69896/10/Acceptance%20Wan%20Mohd%20Azizi%20BIn%20Wan%20Sulaiman-ANTI-ANGIOGENIC%20AND%20TOXICITY%20EFFECTS.pdf application/pdf en http://irep.iium.edu.my/69896/11/Full%20Paper%20DrWan%20Azizi%20ISOPS%20Ankara%20Turkey%20June%202018.pdf Wan Sulaiman, Wan Mohd. Azizi and Unal, Kevser (2018) Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo. In: 12th International Symposium on Pharmaceutical Sciences (ISOPS), 26 to 29th June 2018, Ankara, Turkey. (Unpublished) |
| spellingShingle | RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents Wan Sulaiman, Wan Mohd. Azizi Unal, Kevser Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo |
| title | Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo |
| title_full | Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo |
| title_fullStr | Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo |
| title_full_unstemmed | Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo |
| title_short | Anti-angiogenic and toxicity effects of Derris trifoliata extract in zebrafish embryo |
| title_sort | anti-angiogenic and toxicity effects of derris trifoliata extract in zebrafish embryo |
| topic | RM Therapeutics. Pharmacology RM147 Administration of Drugs and Other Therapeutic Agents |
| url | http://irep.iium.edu.my/69896/ http://irep.iium.edu.my/69896/3/ISOPS12%20Ankara%20Turkiye%20%20oral%20DrWan%20Azizi%2027.06.2018.pdf http://irep.iium.edu.my/69896/9/ISOPS12-AbstractBook.pdf http://irep.iium.edu.my/69896/10/Acceptance%20Wan%20Mohd%20Azizi%20BIn%20Wan%20Sulaiman-ANTI-ANGIOGENIC%20AND%20TOXICITY%20EFFECTS.pdf http://irep.iium.edu.my/69896/11/Full%20Paper%20DrWan%20Azizi%20ISOPS%20Ankara%20Turkey%20June%202018.pdf |