PEGylation of PLGA and PCL nanoparticles enhanced the cytotoxicity of loaded 5-flurouracil
Introduction: The high metabolic rate and the short biological half-life of 5-flourouracil (5-FU) required a continuous administration of large doses and consequently resulting in high profile of adverse effects. Incorporation of 5-FU into biodegradable nanoparticles (NPs) would enhance the therapeu...
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