Is asiaticoside effective against pain?
Centella asiatica or locally known as “Pegaga” is a well-known herb that has been used in folklore medicine for centuries to treat skin problem, asthma, sstomach disorder and to improve memory. Moreover, Centella asiatica extracts exhibited significant antinocicetive activities at the central and pe...
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English |
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Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://irep.iium.edu.my/68950/ http://irep.iium.edu.my/68950/1/ayumi_MSAB2018.pdf |
| _version_ | 1848787030291513344 |
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| author | Mohammad, Rasyidah Ryta Ayumi Shaik Mohamed Mossadeq, Wan Mastura Zakaria, Zainul Amiruddin Bakhtiar, M. Taher |
| author_facet | Mohammad, Rasyidah Ryta Ayumi Shaik Mohamed Mossadeq, Wan Mastura Zakaria, Zainul Amiruddin Bakhtiar, M. Taher |
| author_sort | Mohammad, Rasyidah Ryta Ayumi |
| building | IIUM Repository |
| collection | Online Access |
| description | Centella asiatica or locally known as “Pegaga” is a well-known herb that has been used in folklore medicine for centuries to treat skin problem, asthma, sstomach disorder and to improve memory. Moreover, Centella asiatica extracts exhibited significant antinocicetive activities at the central and peripheral levels. This , this research aimed to evaluate the antinociceptive activities of asiaticoside, the main bioactive constituent of Centella asiatica. We evaluated the effect of asiaticoside (1,3,5 and 10 mg/kg, orally) on the acetic acid induced abdominal constriction test and the hot plate test in mice. Our data showed that the highest dose of asiticoside (10 mg/kg) significantly (p<0.05) inhibited the abdiomial constrictions by 58.3%. Moreover, asiaticoside prolongied the latency (sec) spent by each mouse on he hot plate surface. In conclusion, asiaticoside induces analgesia at the central and peripheral levels. Further studies are required to elucidate its mechanism(s) of action. |
| first_indexed | 2025-11-14T17:18:27Z |
| format | Proceeding Paper |
| id | iium-68950 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:18:27Z |
| publishDate | 2018 |
| publisher | Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-689502019-07-03T07:28:41Z http://irep.iium.edu.my/68950/ Is asiaticoside effective against pain? Mohammad, Rasyidah Ryta Ayumi Shaik Mohamed Mossadeq, Wan Mastura Zakaria, Zainul Amiruddin Bakhtiar, M. Taher RS Pharmacy and materia medica Centella asiatica or locally known as “Pegaga” is a well-known herb that has been used in folklore medicine for centuries to treat skin problem, asthma, sstomach disorder and to improve memory. Moreover, Centella asiatica extracts exhibited significant antinocicetive activities at the central and peripheral levels. This , this research aimed to evaluate the antinociceptive activities of asiaticoside, the main bioactive constituent of Centella asiatica. We evaluated the effect of asiaticoside (1,3,5 and 10 mg/kg, orally) on the acetic acid induced abdominal constriction test and the hot plate test in mice. Our data showed that the highest dose of asiticoside (10 mg/kg) significantly (p<0.05) inhibited the abdiomial constrictions by 58.3%. Moreover, asiaticoside prolongied the latency (sec) spent by each mouse on he hot plate surface. In conclusion, asiaticoside induces analgesia at the central and peripheral levels. Further studies are required to elucidate its mechanism(s) of action. Universiti Kebangsaan Malaysia 2018 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/68950/1/ayumi_MSAB2018.pdf Mohammad, Rasyidah Ryta Ayumi and Shaik Mohamed Mossadeq, Wan Mastura and Zakaria, Zainul Amiruddin and Bakhtiar, M. Taher (2018) Is asiaticoside effective against pain? In: 15th Symposium of The Malaysian Society of Applied Biology, 29th June-1st July 2018, Melaka. http://msabsimposium.blogspot.com/2018/01/the-15th-symposium-malaysian-society-of.html |
| spellingShingle | RS Pharmacy and materia medica Mohammad, Rasyidah Ryta Ayumi Shaik Mohamed Mossadeq, Wan Mastura Zakaria, Zainul Amiruddin Bakhtiar, M. Taher Is asiaticoside effective against pain? |
| title | Is asiaticoside effective against pain? |
| title_full | Is asiaticoside effective against pain? |
| title_fullStr | Is asiaticoside effective against pain? |
| title_full_unstemmed | Is asiaticoside effective against pain? |
| title_short | Is asiaticoside effective against pain? |
| title_sort | is asiaticoside effective against pain? |
| topic | RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/68950/ http://irep.iium.edu.my/68950/ http://irep.iium.edu.my/68950/1/ayumi_MSAB2018.pdf |