In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities
The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to s...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English English |
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Taylor and Francis Ltd.
2018
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| Online Access: | http://irep.iium.edu.my/68498/ http://irep.iium.edu.my/68498/1/Cuscuta.pdf http://irep.iium.edu.my/68498/7/68498_In%20vitro%20evaluation%20of%20Cuscuta%20reflexa%20Roxb_SCOPUS%20inpress.pdf |
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| author | Azad, Abul Kalam Laboni, Farhina Rahman Rashid, Harun Ferdosh, Sahena Rashid, Shah Samiur Kamal, Nurkhalida Labu, Zubair Khalid Islam, M. S. Sarker, Md. Zaidul Islam |
| author_facet | Azad, Abul Kalam Laboni, Farhina Rahman Rashid, Harun Ferdosh, Sahena Rashid, Shah Samiur Kamal, Nurkhalida Labu, Zubair Khalid Islam, M. S. Sarker, Md. Zaidul Islam |
| author_sort | Azad, Abul Kalam |
| building | IIUM Repository |
| collection | Online Access |
| description | The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83lg/mL while the standard ascorbic acid was 2.48mg/ mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p>0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50mg of GAE/g). |
| first_indexed | 2025-11-14T17:17:12Z |
| format | Article |
| id | iium-68498 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:17:12Z |
| publishDate | 2018 |
| publisher | Taylor and Francis Ltd. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-684982019-01-07T07:13:51Z http://irep.iium.edu.my/68498/ In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities Azad, Abul Kalam Laboni, Farhina Rahman Rashid, Harun Ferdosh, Sahena Rashid, Shah Samiur Kamal, Nurkhalida Labu, Zubair Khalid Islam, M. S. Sarker, Md. Zaidul Islam RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry The key purpose of this experiment was to evaluate the thrombolytic, antioxidant, membrane stabilizing and antimicrobial potentials of crude ethanol extracts (CEE) of whole plant, organic and aqueous soluble fractions (OF & AQSF). CEE showed the highest (44.63%) clot lysis activity compared to streptokinase (64.35%). In DPPH study, petroleum ether soluble fraction (PSF) has exhibited IC50 of 18.83lg/mL while the standard ascorbic acid was 2.48mg/ mL. AQSF profoundly inhibited the lysis of erythrocytes (66.20%) which was insignificantly different (p>0.05) to acetylsalicylic acid (71.98%), the reference. However, AQSF showed a significantly stronger level of protection against heat-induced hemolysis (64.80%) as compared with the acetylsalicylic acid (78.90%). CEE, OF and AQSF have displayed reasonable growth of inhibition of tested bacteria compared to negative control and standard drug (77.50mg of GAE/g). Taylor and Francis Ltd. 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68498/1/Cuscuta.pdf application/pdf en http://irep.iium.edu.my/68498/7/68498_In%20vitro%20evaluation%20of%20Cuscuta%20reflexa%20Roxb_SCOPUS%20inpress.pdf Azad, Abul Kalam and Laboni, Farhina Rahman and Rashid, Harun and Ferdosh, Sahena and Rashid, Shah Samiur and Kamal, Nurkhalida and Labu, Zubair Khalid and Islam, M. S. and Sarker, Md. Zaidul Islam (2018) In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities. Natural Product Research. ISSN 14786419 (In Press) https://www.tandfonline.com/doi/abs/10.1080/14786419.2018.1538216?journalCode=gnpl20 10.1080/14786419.2018.1538216 |
| spellingShingle | RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry Azad, Abul Kalam Laboni, Farhina Rahman Rashid, Harun Ferdosh, Sahena Rashid, Shah Samiur Kamal, Nurkhalida Labu, Zubair Khalid Islam, M. S. Sarker, Md. Zaidul Islam In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities |
| title | In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities |
| title_full | In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities |
| title_fullStr | In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities |
| title_full_unstemmed | In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities |
| title_short | In vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities |
| title_sort | in vitro evaluation of cuscuta reflexa roxb. for thrombolytic, antioxidant, membrane stabilizing and antimicrobial activities |
| topic | RS Pharmacy and materia medica RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/68498/ http://irep.iium.edu.my/68498/ http://irep.iium.edu.my/68498/ http://irep.iium.edu.my/68498/1/Cuscuta.pdf http://irep.iium.edu.my/68498/7/68498_In%20vitro%20evaluation%20of%20Cuscuta%20reflexa%20Roxb_SCOPUS%20inpress.pdf |