Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome
Introduction: Acute Kidney Injury (AKI) is common in the intensive care unit (ICU) with high risk of morbidity and mortality. The high incidence of AKI in our population may be attributed to sepsis. We investigated the incidence, risk factors and outcome of AKI in four tertiary Malaysian ICUs. We al...
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Wolters Kluwer Medknow Publications
2018
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| Online Access: | http://irep.iium.edu.my/68309/ http://irep.iium.edu.my/68309/1/ijccm_2018_22_12_831_247743.pdf http://irep.iium.edu.my/68309/7/68309_Acute%20kidney%20injury%20in%20Malaysian%20intensive_scopus.pdf http://irep.iium.edu.my/68309/13/68309%20Acute%20Kidney%20Injury%20in%20Malaysian%20%20WOS.pdf |
| _version_ | 1848786917550718976 |
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| author | Md Ralib, Azrina Nanyan, Suhaila Ramly, Nur Fariza Mat Nor, Mohd Basri |
| author_facet | Md Ralib, Azrina Nanyan, Suhaila Ramly, Nur Fariza Mat Nor, Mohd Basri |
| author_sort | Md Ralib, Azrina |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: Acute Kidney Injury (AKI) is common in the intensive care unit (ICU) with high risk of morbidity and mortality. The high incidence of AKI in our population may be attributed to sepsis. We investigated the incidence, risk factors and outcome of AKI in four tertiary Malaysian ICUs. We also evaluated its association with sepsis.
Materials and Methods: This retrospective cohort study extracted de-identified data from the Malaysian Registry of Intensive Care in four Malaysian tertiary ICUs between January 2010 and December 2014. The study was registered under the NMRR and approved by the ethics committee. AKI was defined as twice the baseline creatinine or urine output < 0.5 ml/kg/h for 12 hours.
Results: Of 26,663 patients, 24.2% had AKI within 24 hours of admission. Patients with AKI were older and had higher severity of illness compared to those without AKI. AKI patients had longer duration of mechanical ventilation, length of ICU and hospital stay. Age, SAPS II Score, and the presence of sepsis and preexisting hypertension, chronic cardiovascular disease independently associated with AKI. 32.3% had sepsis. Patients with both AKI and sepsis had highest risk of mortality (RR 3.43 (3.34 to 3.53)).
Conclusions: AKI is common in our ICU, with higher morbidity and mortality. Independent risk factors of AKI include age, severity of illness, sepsis and preexisting hypertension, chronic cardiovascular disease. AKI independently contributes to mortality. The presence of AKI and sepsis increased the risk of mortality by three times. |
| first_indexed | 2025-11-14T17:16:39Z |
| format | Article |
| id | iium-68309 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:16:39Z |
| publishDate | 2018 |
| publisher | Wolters Kluwer Medknow Publications |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-683092025-04-09T08:56:32Z http://irep.iium.edu.my/68309/ Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome Md Ralib, Azrina Nanyan, Suhaila Ramly, Nur Fariza Mat Nor, Mohd Basri R Medicine (General) Introduction: Acute Kidney Injury (AKI) is common in the intensive care unit (ICU) with high risk of morbidity and mortality. The high incidence of AKI in our population may be attributed to sepsis. We investigated the incidence, risk factors and outcome of AKI in four tertiary Malaysian ICUs. We also evaluated its association with sepsis. Materials and Methods: This retrospective cohort study extracted de-identified data from the Malaysian Registry of Intensive Care in four Malaysian tertiary ICUs between January 2010 and December 2014. The study was registered under the NMRR and approved by the ethics committee. AKI was defined as twice the baseline creatinine or urine output < 0.5 ml/kg/h for 12 hours. Results: Of 26,663 patients, 24.2% had AKI within 24 hours of admission. Patients with AKI were older and had higher severity of illness compared to those without AKI. AKI patients had longer duration of mechanical ventilation, length of ICU and hospital stay. Age, SAPS II Score, and the presence of sepsis and preexisting hypertension, chronic cardiovascular disease independently associated with AKI. 32.3% had sepsis. Patients with both AKI and sepsis had highest risk of mortality (RR 3.43 (3.34 to 3.53)). Conclusions: AKI is common in our ICU, with higher morbidity and mortality. Independent risk factors of AKI include age, severity of illness, sepsis and preexisting hypertension, chronic cardiovascular disease. AKI independently contributes to mortality. The presence of AKI and sepsis increased the risk of mortality by three times. Wolters Kluwer Medknow Publications 2018-12 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68309/1/ijccm_2018_22_12_831_247743.pdf application/pdf en http://irep.iium.edu.my/68309/7/68309_Acute%20kidney%20injury%20in%20Malaysian%20intensive_scopus.pdf application/pdf en http://irep.iium.edu.my/68309/13/68309%20Acute%20Kidney%20Injury%20in%20Malaysian%20%20WOS.pdf Md Ralib, Azrina and Nanyan, Suhaila and Ramly, Nur Fariza and Mat Nor, Mohd Basri (2018) Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome. Indian Journal of Critical Care Medicine, 22 (12). pp. 831-835. ISSN 0972-5229 E-ISSN 1998-359X http://www.ijccm.org 10.4103/ijccm.IJCCM_193_18 |
| spellingShingle | R Medicine (General) Md Ralib, Azrina Nanyan, Suhaila Ramly, Nur Fariza Mat Nor, Mohd Basri Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome |
| title | Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome |
| title_full | Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome |
| title_fullStr | Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome |
| title_full_unstemmed | Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome |
| title_short | Acute kidney injury in Malaysian intensive care setting: incidences, risk factors and outcome |
| title_sort | acute kidney injury in malaysian intensive care setting: incidences, risk factors and outcome |
| topic | R Medicine (General) |
| url | http://irep.iium.edu.my/68309/ http://irep.iium.edu.my/68309/ http://irep.iium.edu.my/68309/ http://irep.iium.edu.my/68309/1/ijccm_2018_22_12_831_247743.pdf http://irep.iium.edu.my/68309/7/68309_Acute%20kidney%20injury%20in%20Malaysian%20intensive_scopus.pdf http://irep.iium.edu.my/68309/13/68309%20Acute%20Kidney%20Injury%20in%20Malaysian%20%20WOS.pdf |