Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum
Stereospermum fimbriatum or locally known as “ Chicha ” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. This study was designed to evaluate the antimicrobial potential of S. fimbriatum ’ s stem bark against 11 pathogens and isolate its bioactive compound. Succes...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English English English |
| Published: |
Taylors & Francis
2020
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/19/Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound%20from%20an%20untapped%20plant%20Stereospermum%20fimbriatum.pdf http://irep.iium.edu.my/68100/25/68100_Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound_Scopus.pdf http://irep.iium.edu.my/68100/26/68100_Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound_WOS.pdf |
| _version_ | 1848786881738702848 |
|---|---|
| author | Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Ali Shah, Syed Adnan Md. Jaffri, Juliana Ghafoor, Kashif Helal Uddin, A.B.M. Ferdosh, Sahena Sarker, Md. Zaidul Islam |
| author_facet | Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Ali Shah, Syed Adnan Md. Jaffri, Juliana Ghafoor, Kashif Helal Uddin, A.B.M. Ferdosh, Sahena Sarker, Md. Zaidul Islam |
| author_sort | Awang, Anis Fadhlina Izyani |
| building | IIUM Repository |
| collection | Online Access |
| description | Stereospermum fimbriatum or locally known as “ Chicha ” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. This study was designed to evaluate the antimicrobial potential of S. fimbriatum ’ s stem bark against 11 pathogens and isolate its bioactive compound. Successive soxhlet extraction was conducted using n-hexane, dichloromethane DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum ’ s extract. The DCM extract of stem bark(DS) was the most potent extract followed by n-hexane extract of the stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 m g/mL to 6.25 m g/mL, against S. epidermidis,MRSA and S. aureus. Thus, S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections,specifically, MRSA. |
| first_indexed | 2025-11-14T17:16:05Z |
| format | Article |
| id | iium-68100 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:16:05Z |
| publishDate | 2020 |
| publisher | Taylors & Francis |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-681002022-11-08T05:01:15Z http://irep.iium.edu.my/68100/ Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Ali Shah, Syed Adnan Md. Jaffri, Juliana Ghafoor, Kashif Helal Uddin, A.B.M. Ferdosh, Sahena Sarker, Md. Zaidul Islam QD Chemistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Stereospermum fimbriatum or locally known as “ Chicha ” is traditionally used for itchy skin, earache, stomachache and postpartum treatments. This study was designed to evaluate the antimicrobial potential of S. fimbriatum ’ s stem bark against 11 pathogens and isolate its bioactive compound. Successive soxhlet extraction was conducted using n-hexane, dichloromethane DCM) and methanol. Disc diffusion, minimum inhibitory and bactericidal concentration (MIC & MBC) assays were done to examine the antimicrobial activity. Bioassay-guided isolation was conducted on S. fimbriatum ’ s extract. The DCM extract of stem bark(DS) was the most potent extract followed by n-hexane extract of the stem bark (NS). A novel compound was isolated and coded as C1 which demonstrated potent antibacterial effects with the MIC values as low as 3.13 m g/mL to 6.25 m g/mL, against S. epidermidis,MRSA and S. aureus. Thus, S. fimbriatum could be a potential source of antimicrobial agents for the treatment of skin infections,specifically, MRSA. Taylors & Francis 2020-02-01 Article PeerReviewed application/pdf en http://irep.iium.edu.my/68100/19/Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound%20from%20an%20untapped%20plant%20Stereospermum%20fimbriatum.pdf application/pdf en http://irep.iium.edu.my/68100/25/68100_Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound_Scopus.pdf application/pdf en http://irep.iium.edu.my/68100/26/68100_Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound_WOS.pdf Awang, Anis Fadhlina Izyani and Ahmed, Qamar Uddin and Ali Shah, Syed Adnan and Md. Jaffri, Juliana and Ghafoor, Kashif and Helal Uddin, A.B.M. and Ferdosh, Sahena and Sarker, Md. Zaidul Islam (2020) Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum. Natural Product Research, 34 (5). pp. 629-637. ISSN 1478-6419 E-ISSN 1478-6427 https://www.tandfonline.com/doi/abs/10.1080/14786419.2018.1494170?journalCode=gnpl20 10.1080/14786419.2018.1494170 |
| spellingShingle | QD Chemistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Awang, Anis Fadhlina Izyani Ahmed, Qamar Uddin Ali Shah, Syed Adnan Md. Jaffri, Juliana Ghafoor, Kashif Helal Uddin, A.B.M. Ferdosh, Sahena Sarker, Md. Zaidul Islam Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum |
| title | Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum |
| title_full | Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum |
| title_fullStr | Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum |
| title_full_unstemmed | Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum |
| title_short | Isolation and characterization of novel antibacterial compound from an untapped plant, Stereospermum fimbriatum |
| title_sort | isolation and characterization of novel antibacterial compound from an untapped plant, stereospermum fimbriatum |
| topic | QD Chemistry RS Pharmacy and materia medica RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/ http://irep.iium.edu.my/68100/19/Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound%20from%20an%20untapped%20plant%20Stereospermum%20fimbriatum.pdf http://irep.iium.edu.my/68100/25/68100_Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound_Scopus.pdf http://irep.iium.edu.my/68100/26/68100_Isolation%20and%20characterization%20of%20novel%20antibacterial%20compound_WOS.pdf |