Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum
Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent diabetes mellitus in adults. Sustain release drugs help to improve...
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| Format: | Article |
| Language: | English |
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Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia
2018
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| Online Access: | http://irep.iium.edu.my/67661/ http://irep.iium.edu.my/67661/1/Preliminary%20Study%20on%20the%20Formulation%20of%20Syariah%20-Dr.%20Helal.pdf |
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| author | Mat Zin, Nik Mohamad Lukman Abd Mubin, Anis Syazwani Mohd Nawi, Mohamed Sufian Helal Uddin, A.B.M. Kasmuri, Abdul Razak Mandal, Uttam Kumar Umar |
| author_facet | Mat Zin, Nik Mohamad Lukman Abd Mubin, Anis Syazwani Mohd Nawi, Mohamed Sufian Helal Uddin, A.B.M. Kasmuri, Abdul Razak Mandal, Uttam Kumar Umar |
| author_sort | Mat Zin, Nik Mohamad Lukman |
| building | IIUM Repository |
| collection | Online Access |
| description | Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a
second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent
diabetes mellitus in adults. Sustain release drugs help to improve drugs bioavailability by controlling the
time of drug release or prolonging it. We are reporting the preliminary formulation of sustain release
gliclazide tablets with careful choice of all the ingredients and processes related to syariah compliance
manufacturing of pharmaceutical products. In this work, xanthan gum, a natural gum was used to achieve
the sustain release criteria. The tablets were produced by wet granulation and semi-automatic tableting
process. Tablet characterisation was done following the British Pharmacopoeia (BP) criteria. We expect that
the outcome of our study will result in a suitable formulation that could be useful for the formulation of
such product that will be helpful for the Muslim patient especially during the fasting month. |
| first_indexed | 2025-11-14T17:14:44Z |
| format | Article |
| id | iium-67661 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:14:44Z |
| publishDate | 2018 |
| publisher | Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-676612022-11-07T02:44:26Z http://irep.iium.edu.my/67661/ Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum Mat Zin, Nik Mohamad Lukman Abd Mubin, Anis Syazwani Mohd Nawi, Mohamed Sufian Helal Uddin, A.B.M. Kasmuri, Abdul Razak Mandal, Uttam Kumar Umar QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Gliclazide (1-(3,3a,4,5,6,6a-hexahydro-1H-cyclopenta[c]pyrrol-2-yl)-3-(4-methylphenyl)sulfonylurea) is a second-generation sulfonylurea which is orally administered in the treatment of non-insulin-dependent diabetes mellitus in adults. Sustain release drugs help to improve drugs bioavailability by controlling the time of drug release or prolonging it. We are reporting the preliminary formulation of sustain release gliclazide tablets with careful choice of all the ingredients and processes related to syariah compliance manufacturing of pharmaceutical products. In this work, xanthan gum, a natural gum was used to achieve the sustain release criteria. The tablets were produced by wet granulation and semi-automatic tableting process. Tablet characterisation was done following the British Pharmacopoeia (BP) criteria. We expect that the outcome of our study will result in a suitable formulation that could be useful for the formulation of such product that will be helpful for the Muslim patient especially during the fasting month. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia 2018-10-18 Article PeerReviewed application/pdf en http://irep.iium.edu.my/67661/1/Preliminary%20Study%20on%20the%20Formulation%20of%20Syariah%20-Dr.%20Helal.pdf Mat Zin, Nik Mohamad Lukman and Abd Mubin, Anis Syazwani and Mohd Nawi, Mohamed Sufian and Helal Uddin, A.B.M. and Kasmuri, Abdul Razak and Mandal, Uttam Kumar Umar (2018) Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum. International Medical journal Malaysia (IMJM), 17 (Special Issue 2). pp. 1-4. ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/volume_17_special_issue_2/Pages-from-2WCII-SI2-001.pdf |
| spellingShingle | QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry Mat Zin, Nik Mohamad Lukman Abd Mubin, Anis Syazwani Mohd Nawi, Mohamed Sufian Helal Uddin, A.B.M. Kasmuri, Abdul Razak Mandal, Uttam Kumar Umar Preliminary study on the formulation of syariah compliant generic sustained release gliclazide tablet using xanthan gum |
| title | Preliminary study on the formulation of syariah
compliant generic sustained release gliclazide tablet
using xanthan gum |
| title_full | Preliminary study on the formulation of syariah
compliant generic sustained release gliclazide tablet
using xanthan gum |
| title_fullStr | Preliminary study on the formulation of syariah
compliant generic sustained release gliclazide tablet
using xanthan gum |
| title_full_unstemmed | Preliminary study on the formulation of syariah
compliant generic sustained release gliclazide tablet
using xanthan gum |
| title_short | Preliminary study on the formulation of syariah
compliant generic sustained release gliclazide tablet
using xanthan gum |
| title_sort | preliminary study on the formulation of syariah
compliant generic sustained release gliclazide tablet
using xanthan gum |
| topic | QD Chemistry RS192 Materia Medica-Pharmaceutical Technology RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/67661/ http://irep.iium.edu.my/67661/ http://irep.iium.edu.my/67661/1/Preliminary%20Study%20on%20the%20Formulation%20of%20Syariah%20-Dr.%20Helal.pdf |