Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study
Introduction: Presence of scattered gamma photons in the projection data of Tc-99m Myocardial SPECT degrades the image quality. Thus, the efficacy of SPECT in patient studies is hampered. This work is aimed at enhancing the image quality and accuracy in measurement of cold defect size by pre-filteri...
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| Format: | Proceeding Paper |
| Language: | English English |
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2017
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| Online Access: | http://irep.iium.edu.my/67342/ http://irep.iium.edu.my/67342/1/7thGNM_Abstract_Sayed.pdf http://irep.iium.edu.my/67342/7/Abstract%20_Acceptance%20Letter.pdf |
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| author | Sayed, Inayatullah Shah Mohd Zulkele, Nurul Farizan Che Daud, Mohd. Zamzuri Abdul Rahim, Mohamad Shahrir |
| author_facet | Sayed, Inayatullah Shah Mohd Zulkele, Nurul Farizan Che Daud, Mohd. Zamzuri Abdul Rahim, Mohamad Shahrir |
| author_sort | Sayed, Inayatullah Shah |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: Presence of scattered gamma photons in the projection data of Tc-99m Myocardial SPECT degrades the image quality. Thus, the efficacy of SPECT in patient studies is hampered. This work is aimed at enhancing the image quality and accuracy in measurement of cold defect size by pre-filtering of scattered gamma photons with physical filter.
Material and method: GE Infinia II gamma camera with LEHR collimator was used. A flat sheet of Aluminum 0.1 mm thick, 55 cm x 44 cm sized was mounted on the outer surface of collimator. Carlson’s phantom with cardiac insert simulating the left ventricle was scanned. A polystyrene cold defect (9.8 mm x 9.8 mm x 9.8 mm) was placed at the anterior side of the myocardial wall. Water was filled into myocardial wall chamber; Tc-99m with concentration of 3.9μCi/ml was injected. It was inserted into the cylindrical tank after water was filled. Tc-99m radioactivity with 1.1μCi/ml concentration as background was administered. The chamber was positioned according to the orientation of human heart. Energy window (20%) centred at 140 keV was adjusted. Data were registered into a 128x128 matrix with sixty projections with and without physical filter opting step-and-shoot acquisition extended in a 180o arc from 45˚ right anterior oblique to 45˚ left posterior oblique. Filtered back projection method was used for image reconstruction by selecting Butterworth filter of order 10 and cut-off frequency 0.40/cm. Chang’s attenuation correction was applied.
Results: Cold defect size measurement and image contour analysis of short axis views show significant improvement (p<0.05) in the accuracy in defect size and image quality with physical filter. Our study demonstrates that this technique is effective in removing scattered gamma photons from SPECT projection data.
Conclusion: Physical filter technique may be implemented in Tc-99m myocardial SPECT clinical studies. Yet still, further studies are required with different phantoms which mimic the human heart closely. |
| first_indexed | 2025-11-14T17:13:53Z |
| format | Proceeding Paper |
| id | iium-67342 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:13:53Z |
| publishDate | 2017 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-673422018-11-27T01:36:38Z http://irep.iium.edu.my/67342/ Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study Sayed, Inayatullah Shah Mohd Zulkele, Nurul Farizan Che Daud, Mohd. Zamzuri Abdul Rahim, Mohamad Shahrir QC Physics Introduction: Presence of scattered gamma photons in the projection data of Tc-99m Myocardial SPECT degrades the image quality. Thus, the efficacy of SPECT in patient studies is hampered. This work is aimed at enhancing the image quality and accuracy in measurement of cold defect size by pre-filtering of scattered gamma photons with physical filter. Material and method: GE Infinia II gamma camera with LEHR collimator was used. A flat sheet of Aluminum 0.1 mm thick, 55 cm x 44 cm sized was mounted on the outer surface of collimator. Carlson’s phantom with cardiac insert simulating the left ventricle was scanned. A polystyrene cold defect (9.8 mm x 9.8 mm x 9.8 mm) was placed at the anterior side of the myocardial wall. Water was filled into myocardial wall chamber; Tc-99m with concentration of 3.9μCi/ml was injected. It was inserted into the cylindrical tank after water was filled. Tc-99m radioactivity with 1.1μCi/ml concentration as background was administered. The chamber was positioned according to the orientation of human heart. Energy window (20%) centred at 140 keV was adjusted. Data were registered into a 128x128 matrix with sixty projections with and without physical filter opting step-and-shoot acquisition extended in a 180o arc from 45˚ right anterior oblique to 45˚ left posterior oblique. Filtered back projection method was used for image reconstruction by selecting Butterworth filter of order 10 and cut-off frequency 0.40/cm. Chang’s attenuation correction was applied. Results: Cold defect size measurement and image contour analysis of short axis views show significant improvement (p<0.05) in the accuracy in defect size and image quality with physical filter. Our study demonstrates that this technique is effective in removing scattered gamma photons from SPECT projection data. Conclusion: Physical filter technique may be implemented in Tc-99m myocardial SPECT clinical studies. Yet still, further studies are required with different phantoms which mimic the human heart closely. 2017-12-09 Proceeding Paper NonPeerReviewed application/pdf en http://irep.iium.edu.my/67342/1/7thGNM_Abstract_Sayed.pdf application/pdf en http://irep.iium.edu.my/67342/7/Abstract%20_Acceptance%20Letter.pdf Sayed, Inayatullah Shah and Mohd Zulkele, Nurul Farizan and Che Daud, Mohd. Zamzuri and Abdul Rahim, Mohamad Shahrir (2017) Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study. In: 7th Gulf Nuclear Medicine Conference 2017, 9th-12th December 2017, Muscat, Oman. (Unpublished) |
| spellingShingle | QC Physics Sayed, Inayatullah Shah Mohd Zulkele, Nurul Farizan Che Daud, Mohd. Zamzuri Abdul Rahim, Mohamad Shahrir Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study |
| title | Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study |
| title_full | Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study |
| title_fullStr | Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study |
| title_full_unstemmed | Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study |
| title_short | Tc-99m myocardial SPECT image quality improvement with a physical filter as scattered gamma photon absorber: phantom study |
| title_sort | tc-99m myocardial spect image quality improvement with a physical filter as scattered gamma photon absorber: phantom study |
| topic | QC Physics |
| url | http://irep.iium.edu.my/67342/ http://irep.iium.edu.my/67342/1/7thGNM_Abstract_Sayed.pdf http://irep.iium.edu.my/67342/7/Abstract%20_Acceptance%20Letter.pdf |