siRNA blocking of mammalian target of rapamycin (mTOR) attenuates pathology in annonacin-induced tauopathy in mice

siRNA blocking of mammalian target of rapamycin (mTOR) attenuates pathology in annonacin-induced tauopathy in mice

Tauopathy is a pathological hallmark of many neurodegenerative diseases. It is characterized by abnormal aggregates of pathological phosphotau and somatodendritic redistribution. One suggested strategy for treating tauopathy is to stimulate autophagy, hence, getting rid of these pathological protein...

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Bibliographic Details
Main Authors: Salama, Mohamed M., El-Desouky, Sara, Alsayed, Aziza, El-Hussiny, Mahmoud, Magdy, Khaled, Fekry, Emad, Shabka, Osama, El-Khodery, Sabry A., Youssef, Mohamed A., Sobh, Mohamed, Mohamed, Wael Mohamed Yousef
Format: Article
Language:English
English
English
Published: Springer Nature Switzerland AG 2019
Subjects:
R Medicine (General)
RM300 Drugs and their action
Online Access:http://irep.iium.edu.my/67119/
http://irep.iium.edu.my/67119/1/mTOR.pdf
http://irep.iium.edu.my/67119/7/67119_siRNA%20Blocking%20of%20Mammalian%20Target%20of%20Rapamycin%20%28mTOR%29%20Attenuates%20Pathology%20in%20Annonacin-Induced%20Tauopathy%20in%20Mice_wos.pdf
http://irep.iium.edu.my/67119/13/67119_siRNA%20Blocking%20of%20Mammalian%20Target%20of%20Rapamycin%20mTOR_scopus.pdf

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