A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines
Natural polyamines such as putrescine, spermidine, and spermine are crucial for cell growth and proliferation. However, over accumulation of polyamines can lead to the worst scenario which is the progression of cancer cells. The upregulation of polyamine transport system (PTS) activity leads to an o...
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| Format: | Book Chapter |
| Language: | English |
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UPM Press
2018
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| Online Access: | http://irep.iium.edu.my/66989/ http://irep.iium.edu.my/66989/1/66989_A%20Review%20on%20Polyamine%20Analogues-ebook.pdf |
| _version_ | 1848786678236315648 |
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| author | Abdul Ghani, Radiah Halim, Suhana Jamil, Masnizahani Sahabudin, Adzly Hairee |
| author_facet | Abdul Ghani, Radiah Halim, Suhana Jamil, Masnizahani Sahabudin, Adzly Hairee |
| author_sort | Abdul Ghani, Radiah |
| building | IIUM Repository |
| collection | Online Access |
| description | Natural polyamines such as putrescine, spermidine, and spermine are crucial for cell growth and proliferation. However, over accumulation of polyamines can lead to the worst scenario which is the progression of cancer cells. The upregulation of polyamine transport system (PTS) activity leads to an opportunity to develop more specific and effective cancer treatment. Based on this strategy, polyamines are utilized as a vector which inserted with known cytotoxic compound. Perhaps, anticancer drugs that attached to the polyamines are directly targeted the cancer cells without affecting other normal cells and the side effects of the drugs could be reduced or minimized. Therefore the aim of this paper is to review the polyamine analogues which have been synthesized and evaluated as potential anti-cancer agent in various types of cancer cell lines. It is hope that the concept of selective targeting of cancer cells via the polyamine transport system will lead to the development of novel and effective anti-cancer therapies. |
| first_indexed | 2025-11-14T17:12:51Z |
| format | Book Chapter |
| id | iium-66989 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:12:51Z |
| publishDate | 2018 |
| publisher | UPM Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-669892018-10-26T07:41:21Z http://irep.iium.edu.my/66989/ A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines Abdul Ghani, Radiah Halim, Suhana Jamil, Masnizahani Sahabudin, Adzly Hairee QP Physiology Natural polyamines such as putrescine, spermidine, and spermine are crucial for cell growth and proliferation. However, over accumulation of polyamines can lead to the worst scenario which is the progression of cancer cells. The upregulation of polyamine transport system (PTS) activity leads to an opportunity to develop more specific and effective cancer treatment. Based on this strategy, polyamines are utilized as a vector which inserted with known cytotoxic compound. Perhaps, anticancer drugs that attached to the polyamines are directly targeted the cancer cells without affecting other normal cells and the side effects of the drugs could be reduced or minimized. Therefore the aim of this paper is to review the polyamine analogues which have been synthesized and evaluated as potential anti-cancer agent in various types of cancer cell lines. It is hope that the concept of selective targeting of cancer cells via the polyamine transport system will lead to the development of novel and effective anti-cancer therapies. UPM Press 2018-08 Book Chapter PeerReviewed application/pdf en http://irep.iium.edu.my/66989/1/66989_A%20Review%20on%20Polyamine%20Analogues-ebook.pdf Abdul Ghani, Radiah and Halim, Suhana and Jamil, Masnizahani and Sahabudin, Adzly Hairee (2018) A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines. In: Biology: emerging theme in fundamental and applied science. UPM Press, Serdang, Selangor, pp. 154-161. http://www.science.upm.edu.my/ebook-3213 |
| spellingShingle | QP Physiology Abdul Ghani, Radiah Halim, Suhana Jamil, Masnizahani Sahabudin, Adzly Hairee A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines |
| title | A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines |
| title_full | A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines |
| title_fullStr | A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines |
| title_full_unstemmed | A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines |
| title_short | A review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines |
| title_sort | review on polyamine analogues and its cytotoxicity effect against selected human cancer cell lines |
| topic | QP Physiology |
| url | http://irep.iium.edu.my/66989/ http://irep.iium.edu.my/66989/ http://irep.iium.edu.my/66989/1/66989_A%20Review%20on%20Polyamine%20Analogues-ebook.pdf |