Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves
Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos caudatus Kunth, in scavenging free radicals and inhibiting t...
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| Format: | Article |
| Language: | English English |
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UPM Press
2018
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| Online Access: | http://irep.iium.edu.my/66759/ http://irep.iium.edu.my/66759/7/66759%20Chemical%20Profile%2C%20Total%20Phenolic%20Content.pdf http://irep.iium.edu.my/66759/13/66759_Chemical%20profile%2C%20total%20phenolic%20content%2C%20DPPH%20free%20radical%20scavenging_SCOPUS.pdf |
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| author | Wan Ahmad, Wan Nadilah Shaari, Khozirah Khatib, Alfi Abd hamid, Azizah Hamid, Muhajir |
| author_facet | Wan Ahmad, Wan Nadilah Shaari, Khozirah Khatib, Alfi Abd hamid, Azizah Hamid, Muhajir |
| author_sort | Wan Ahmad, Wan Nadilah |
| building | IIUM Repository |
| collection | Online Access |
| description | Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of
the leaf ethanolic extract and solvent fractions of Cosmos caudatus Kunth, in scavenging free radicals and inhibiting the enzyme α-glucosidase. In addition, their metabolite profiles were also characterized using liquid chromatography–mass spectrometry. The bioactivity
was found to be concentrated in the EtOAc and BuOH fractions which largely contained rutin, quercetin 3-O-galactoside, quercetin 3-O-glucoside, quercetin 3-O-xyloside, quercetin
3-O-arabinofuranoside, quercetin 3-O-rhamnoside, and quercetin 3-O-galactoside, as profiled by LC-MS/MS. It was further shown that the flavonoids glycosides contributed to the free radical scavenging and glucose lowering
effects of C. caudatus leaves. The results
indicated that the leaves of C. caudatus are a rich source of bioactive compounds and could be prospective materials for development of new anti-diabetic agents. |
| first_indexed | 2025-11-14T17:12:15Z |
| format | Article |
| id | iium-66759 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:12:15Z |
| publishDate | 2018 |
| publisher | UPM Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-667592019-01-23T04:30:50Z http://irep.iium.edu.my/66759/ Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves Wan Ahmad, Wan Nadilah Shaari, Khozirah Khatib, Alfi Abd hamid, Azizah Hamid, Muhajir RS403 Materia Medica-Pharmaceutical Chemistry Herbs and medicinal plants are major sources of traditional or folk medicines for many countries of the world, including Malaysia. This study evaluated the bioactive potential of the leaf ethanolic extract and solvent fractions of Cosmos caudatus Kunth, in scavenging free radicals and inhibiting the enzyme α-glucosidase. In addition, their metabolite profiles were also characterized using liquid chromatography–mass spectrometry. The bioactivity was found to be concentrated in the EtOAc and BuOH fractions which largely contained rutin, quercetin 3-O-galactoside, quercetin 3-O-glucoside, quercetin 3-O-xyloside, quercetin 3-O-arabinofuranoside, quercetin 3-O-rhamnoside, and quercetin 3-O-galactoside, as profiled by LC-MS/MS. It was further shown that the flavonoids glycosides contributed to the free radical scavenging and glucose lowering effects of C. caudatus leaves. The results indicated that the leaves of C. caudatus are a rich source of bioactive compounds and could be prospective materials for development of new anti-diabetic agents. UPM Press 2018-08 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66759/7/66759%20Chemical%20Profile%2C%20Total%20Phenolic%20Content.pdf application/pdf en http://irep.iium.edu.my/66759/13/66759_Chemical%20profile%2C%20total%20phenolic%20content%2C%20DPPH%20free%20radical%20scavenging_SCOPUS.pdf Wan Ahmad, Wan Nadilah and Shaari, Khozirah and Khatib, Alfi and Abd hamid, Azizah and Hamid, Muhajir (2018) Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves. Pertanika Journal of Tropical Agricultural Science, 41 (3). pp. 1367-1381. ISSN 1511-3701 E-ISSN 2231-8542 http://www.pertanika.upm.edu.my/Pertanika%20PAPERS/JTAS%20Vol.%2041%20(3)%20Aug.%202018/32%20JTAS%201327-2018.pdf |
| spellingShingle | RS403 Materia Medica-Pharmaceutical Chemistry Wan Ahmad, Wan Nadilah Shaari, Khozirah Khatib, Alfi Abd hamid, Azizah Hamid, Muhajir Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves |
| title | Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves |
| title_full | Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves |
| title_fullStr | Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves |
| title_full_unstemmed | Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves |
| title_short | Chemical profile, total phenolic content, DPPH free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves |
| title_sort | chemical profile, total phenolic content, dpph free radical scavenging and α-lucosidase inhibitory activities of cosmos caudatus kunth leaves |
| topic | RS403 Materia Medica-Pharmaceutical Chemistry |
| url | http://irep.iium.edu.my/66759/ http://irep.iium.edu.my/66759/ http://irep.iium.edu.my/66759/7/66759%20Chemical%20Profile%2C%20Total%20Phenolic%20Content.pdf http://irep.iium.edu.my/66759/13/66759_Chemical%20profile%2C%20total%20phenolic%20content%2C%20DPPH%20free%20radical%20scavenging_SCOPUS.pdf |