Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models
Neuroinflammation has been closely linked to neurodegeneration that leads to dysfunction of memory and learning where glial fibrillary acidic protein (GFAP) plays important role positively within hippocampus. In experimental neurodegeneration achieved by two-vessel occlusion (2VO) intervention, Ni...
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| Format: | Article |
| Language: | English English |
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University of Dhaka
2018
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| Online Access: | http://irep.iium.edu.my/66688/ http://irep.iium.edu.my/66688/1/66688_Neuroprotective%20Properties%20of%20Nigella%20sativa_article.pdf http://irep.iium.edu.my/66688/2/66688_Neuroprotective%20Properties%20of%20Nigella%20sativa_scopus.pdf |
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| author | Babar, Zahir Uddin Azad, Abul Kalam Wan Sulaiman, Wan Mohd Azizi Uddin, Jalal Labu, Zubair Khalid |
| author_facet | Babar, Zahir Uddin Azad, Abul Kalam Wan Sulaiman, Wan Mohd Azizi Uddin, Jalal Labu, Zubair Khalid |
| author_sort | Babar, Zahir Uddin |
| building | IIUM Repository |
| collection | Online Access |
| description | Neuroinflammation has been closely linked to neurodegeneration that leads to dysfunction of memory
and learning where glial fibrillary acidic protein (GFAP) plays important role positively within hippocampus. In
experimental neurodegeneration achieved by two-vessel occlusion (2VO) intervention, Nigella sativa (L.) seeds
extract (50 mg/kg/day orally) has shown to have anti-neuroinflammatory and antioxidant properties. The brain
hippocampal tissues were humanely collected at the end of 10th treatment week and preserved in Allprotect™
reagent at –80°C. Total RNA was extracted and purified by phenol/chloroform method using kits and reverse
transcribed into cDNA and relatively quantified as per ∆∆Cq. The NSSE treatment showed significantly (p<0.001)
different relative GFAP mRNA expression in the treated group as compared to that of untreated 2VO whilst it was
insignificantly (p>0.5) different to that of healthy control (HC). Prolonged or daily treatment with NSSE (Nigella
sativa (L.) seeds extract) may provide moderate anti-neuroprotective activity within hippocampus. |
| first_indexed | 2025-11-14T17:12:03Z |
| format | Article |
| id | iium-66688 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:12:03Z |
| publishDate | 2018 |
| publisher | University of Dhaka |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-666882018-10-08T07:20:34Z http://irep.iium.edu.my/66688/ Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models Babar, Zahir Uddin Azad, Abul Kalam Wan Sulaiman, Wan Mohd Azizi Uddin, Jalal Labu, Zubair Khalid RC Internal medicine RC321 Neuroscience. Biological psychiatry. Neuropsychiatry Neuroinflammation has been closely linked to neurodegeneration that leads to dysfunction of memory and learning where glial fibrillary acidic protein (GFAP) plays important role positively within hippocampus. In experimental neurodegeneration achieved by two-vessel occlusion (2VO) intervention, Nigella sativa (L.) seeds extract (50 mg/kg/day orally) has shown to have anti-neuroinflammatory and antioxidant properties. The brain hippocampal tissues were humanely collected at the end of 10th treatment week and preserved in Allprotect™ reagent at –80°C. Total RNA was extracted and purified by phenol/chloroform method using kits and reverse transcribed into cDNA and relatively quantified as per ∆∆Cq. The NSSE treatment showed significantly (p<0.001) different relative GFAP mRNA expression in the treated group as compared to that of untreated 2VO whilst it was insignificantly (p>0.5) different to that of healthy control (HC). Prolonged or daily treatment with NSSE (Nigella sativa (L.) seeds extract) may provide moderate anti-neuroprotective activity within hippocampus. University of Dhaka 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66688/1/66688_Neuroprotective%20Properties%20of%20Nigella%20sativa_article.pdf application/pdf en http://irep.iium.edu.my/66688/2/66688_Neuroprotective%20Properties%20of%20Nigella%20sativa_scopus.pdf Babar, Zahir Uddin and Azad, Abul Kalam and Wan Sulaiman, Wan Mohd Azizi and Uddin, Jalal and Labu, Zubair Khalid (2018) Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models. Dhaka University Journal of Pharmaceutical Sciences, 17 (1). pp. 113-121. ISSN 1816-1820 E-ISSN 1816-1839 https://www.banglajol.info/index.php/JPharma/article/view/37127/25101 10.3329/dujps.v17i1.37127 |
| spellingShingle | RC Internal medicine RC321 Neuroscience. Biological psychiatry. Neuropsychiatry Babar, Zahir Uddin Azad, Abul Kalam Wan Sulaiman, Wan Mohd Azizi Uddin, Jalal Labu, Zubair Khalid Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models |
| title | Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models |
| title_full | Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models |
| title_fullStr | Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models |
| title_full_unstemmed | Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models |
| title_short | Neuroprotective properties of nigella sativa (L.) seeds extract in sprague dawley rats models |
| title_sort | neuroprotective properties of nigella sativa (l.) seeds extract in sprague dawley rats models |
| topic | RC Internal medicine RC321 Neuroscience. Biological psychiatry. Neuropsychiatry |
| url | http://irep.iium.edu.my/66688/ http://irep.iium.edu.my/66688/ http://irep.iium.edu.my/66688/ http://irep.iium.edu.my/66688/1/66688_Neuroprotective%20Properties%20of%20Nigella%20sativa_article.pdf http://irep.iium.edu.my/66688/2/66688_Neuroprotective%20Properties%20of%20Nigella%20sativa_scopus.pdf |