Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion
Poor aqueous solubility of drugs results in poor absorption and bioavailability. The objective of solid dispersion technology is to increase the dissolution properties of highly lipophilic drugs, by using different hydrophilic carriers thereby improving their bioavailability. Thi...
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| Format: | Article |
| Language: | English |
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2018
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| Online Access: | http://irep.iium.edu.my/66403/ http://irep.iium.edu.my/66403/1/Dr.%20Helal-JDDT_Published%20article.pdf |
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| author | Helal Uddin, A.B.M. Azad, A.K Jahan, K Sathi, T.S. Sultana, R Abbas, Syed A |
| author_facet | Helal Uddin, A.B.M. Azad, A.K Jahan, K Sathi, T.S. Sultana, R Abbas, Syed A |
| author_sort | Helal Uddin, A.B.M. |
| building | IIUM Repository |
| collection | Online Access |
| description | Poor aqueous solubility of drugs results in poor absorption and bioavailability. The objective of solid dispersion technology is to
increase the dissolution properties of highly lipophilic drugs, by using different hydrophilic carriers thereby improving their
bioavailability. This technology is useful for enhancing the dissolution, absorption and therapeutic efficacy of drugs in dosage forms.
Albendazole is a broad-spectrum antihelmintic agent used for the treatment of a variety of parasitic worm infestations. It is
practically insoluble in water but slightly soluble in solvents like chloroform, methanol, ethyl acetate, and acetonitrile. The aim of
our study was to improve the dissolution profile of albendazole using HPMC K 100 LV, Kollidon VA64 and Mannitol as carriers by
solid dispersion techniques. From the prepared solid dispersion, formulation code CSF5 showed better result where carrier was
HMPC K 100 LV at 1:10 ratio in solvent evaporation method. The HPMC K 100 LV showed better result for both kneading and
solvent evaporation methods. Moreover, among the method employed, solvent evaporation method showed better solubility of drug
at 60 min also at 1:10 ratio which was 78.86%. Results indicated that current formulation of solid dispersion is a promising approach
for enhancing drug solubility and dissolution. |
| first_indexed | 2025-11-14T17:11:08Z |
| format | Article |
| id | iium-66403 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:11:08Z |
| publishDate | 2018 |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-664032022-11-07T02:56:05Z http://irep.iium.edu.my/66403/ Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion Helal Uddin, A.B.M. Azad, A.K Jahan, K Sathi, T.S. Sultana, R Abbas, Syed A QD Chemistry RS Pharmacy and materia medica Poor aqueous solubility of drugs results in poor absorption and bioavailability. The objective of solid dispersion technology is to increase the dissolution properties of highly lipophilic drugs, by using different hydrophilic carriers thereby improving their bioavailability. This technology is useful for enhancing the dissolution, absorption and therapeutic efficacy of drugs in dosage forms. Albendazole is a broad-spectrum antihelmintic agent used for the treatment of a variety of parasitic worm infestations. It is practically insoluble in water but slightly soluble in solvents like chloroform, methanol, ethyl acetate, and acetonitrile. The aim of our study was to improve the dissolution profile of albendazole using HPMC K 100 LV, Kollidon VA64 and Mannitol as carriers by solid dispersion techniques. From the prepared solid dispersion, formulation code CSF5 showed better result where carrier was HMPC K 100 LV at 1:10 ratio in solvent evaporation method. The HPMC K 100 LV showed better result for both kneading and solvent evaporation methods. Moreover, among the method employed, solvent evaporation method showed better solubility of drug at 60 min also at 1:10 ratio which was 78.86%. Results indicated that current formulation of solid dispersion is a promising approach for enhancing drug solubility and dissolution. 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/66403/1/Dr.%20Helal-JDDT_Published%20article.pdf Helal Uddin, A.B.M. and Azad, A.K and Jahan, K and Sathi, T.S. and Sultana, R and Abbas, Syed A (2018) Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion. Journal of Drug Delivery and Therapeutics. pp. 475-480. ISSN 2250-1177 |
| spellingShingle | QD Chemistry RS Pharmacy and materia medica Helal Uddin, A.B.M. Azad, A.K Jahan, K Sathi, T.S. Sultana, R Abbas, Syed A Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion |
| title | Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion |
| title_full | Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion |
| title_fullStr | Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion |
| title_full_unstemmed | Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion |
| title_short | Improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion |
| title_sort | improvement of dissolution properties of albendazole fromdifferent methods of solid dispersion |
| topic | QD Chemistry RS Pharmacy and materia medica |
| url | http://irep.iium.edu.my/66403/ http://irep.iium.edu.my/66403/1/Dr.%20Helal-JDDT_Published%20article.pdf |