Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility
Oil/water emulsion solvent evaporation method was employed to fabricate PCL microcarriers. The surface of these microcarriers were modified with porogen, UV/O3 system and gelatin. The porous network channels were generated inside the microcarrier by introducing camphene. The average pore size of...
| Main Authors: | , , , , |
|---|---|
| Format: | Proceeding Paper |
| Language: | English |
| Published: |
International Institute for Halal Research and Training (INHART), IIUM
2018
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/66282/ http://irep.iium.edu.my/66282/6/66282.pdf |
| _version_ | 1848786548562067456 |
|---|---|
| author | Samsudin, Nurhusna Hashim, Yumi Zuhanis Has-Yun Arifin, Mohd Azmir Mel, Maizirwan Mohd. Salleh, Hamzah |
| author_facet | Samsudin, Nurhusna Hashim, Yumi Zuhanis Has-Yun Arifin, Mohd Azmir Mel, Maizirwan Mohd. Salleh, Hamzah |
| author_sort | Samsudin, Nurhusna |
| building | IIUM Repository |
| collection | Online Access |
| description | Oil/water emulsion solvent evaporation method was employed to fabricate PCL
microcarriers. The surface of these microcarriers were modified with porogen, UV/O3 system
and gelatin. The porous network channels were generated inside the microcarrier by
introducing camphene. The average pore size of 11.74±8.32 μm was obtained with the
concentration of 20% (w/v) of camphene. The porous PCL microcarrier was further tailored
with gelatin through surface treatment with UV/O3 system and gelatin immobilization. Vero
cells attach and proliferate well on the gelatin coated porous PCL microcarrier with maximum
cell number of 3.90 x 105
cells/ml as compared to cell proliferation on UV/O3 treated porous
PCL microcarrier (1.83 x 105 cells/ml). The developed halal microcarrier may be potentially
applicable as a cell delivery scaffold for cell tissue culture and tissue engineering application |
| first_indexed | 2025-11-14T17:10:47Z |
| format | Proceeding Paper |
| id | iium-66282 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:10:47Z |
| publishDate | 2018 |
| publisher | International Institute for Halal Research and Training (INHART), IIUM |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-662822023-02-08T03:22:47Z http://irep.iium.edu.my/66282/ Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility Samsudin, Nurhusna Hashim, Yumi Zuhanis Has-Yun Arifin, Mohd Azmir Mel, Maizirwan Mohd. Salleh, Hamzah Q Science (General) TP248.13 Biotechnology Oil/water emulsion solvent evaporation method was employed to fabricate PCL microcarriers. The surface of these microcarriers were modified with porogen, UV/O3 system and gelatin. The porous network channels were generated inside the microcarrier by introducing camphene. The average pore size of 11.74±8.32 μm was obtained with the concentration of 20% (w/v) of camphene. The porous PCL microcarrier was further tailored with gelatin through surface treatment with UV/O3 system and gelatin immobilization. Vero cells attach and proliferate well on the gelatin coated porous PCL microcarrier with maximum cell number of 3.90 x 105 cells/ml as compared to cell proliferation on UV/O3 treated porous PCL microcarrier (1.83 x 105 cells/ml). The developed halal microcarrier may be potentially applicable as a cell delivery scaffold for cell tissue culture and tissue engineering application International Institute for Halal Research and Training (INHART), IIUM 2018 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/66282/6/66282.pdf Samsudin, Nurhusna and Hashim, Yumi Zuhanis Has-Yun and Arifin, Mohd Azmir and Mel, Maizirwan and Mohd. Salleh, Hamzah (2018) Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility. In: International Conference on Halal Innovations in Products and Services 2018 (i-CHIPS 2018), 13th -14th July 2018, Songkla, Thailand. http://halalinst.psu.ac.th/i-chips/ |
| spellingShingle | Q Science (General) TP248.13 Biotechnology Samsudin, Nurhusna Hashim, Yumi Zuhanis Has-Yun Arifin, Mohd Azmir Mel, Maizirwan Mohd. Salleh, Hamzah Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility |
| title | Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility |
| title_full | Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility |
| title_fullStr | Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility |
| title_full_unstemmed | Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility |
| title_short | Surface modification of microporous polycaprolactone (PCL) microcarrier to improve microcarrier biocompatibility |
| title_sort | surface modification of microporous polycaprolactone (pcl) microcarrier to improve microcarrier biocompatibility |
| topic | Q Science (General) TP248.13 Biotechnology |
| url | http://irep.iium.edu.my/66282/ http://irep.iium.edu.my/66282/ http://irep.iium.edu.my/66282/6/66282.pdf |