Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum
Background and Objective: Studies on signal peptides remain little and lacking to Cryptosporidium. This study represents the first attempt to investigate selected putative protein sequences of Cryptosporidium parvum in its established genome database for signal peptide. Methods: Prediction analysis...
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| Format: | Article |
| Language: | English English |
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Asian Network for Scientific Information
2018
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| Online Access: | http://irep.iium.edu.my/65691/ http://irep.iium.edu.my/65691/1/65691_Signal%20peptide%20sequence%20analysis.pdf http://irep.iium.edu.my/65691/2/65691_Signal%20peptide%20sequence%20analysis_SCOPUS.pdf |
| _version_ | 1848786432688128000 |
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| author | Barudin, Mohd Aiman Md Isa, Muhammad Lokman Mat Yusof, Afzan |
| author_facet | Barudin, Mohd Aiman Md Isa, Muhammad Lokman Mat Yusof, Afzan |
| author_sort | Barudin, Mohd Aiman |
| building | IIUM Repository |
| collection | Online Access |
| description | Background and Objective: Studies on signal peptides remain little and lacking to Cryptosporidium. This study represents the first attempt to investigate selected putative protein sequences of Cryptosporidium parvum in its established genome database for signal peptide. Methods: Prediction analysis of protein sequences and identification of signal peptides on this parasite were analysed by SignalP 4.1 server. A total of 100 protein sequences were randomly selected and analysed, of which 6 (6%) corresponded to be predicted as signal peptide sequences. Results: Based on the comparison of sequences with database protein sequences in GenBank NCBI, almost all protein sequences were highly conserved with other protein sequences from different species of Cryptosporidium. Considering the secretory proteins in Cryptosporidium, several virulence protein sequences of this parasite may also show presence of N-terminal signal peptide or not.
Conclusions: Hence, further studies need to be carried out for identification of N-terminal signal peptide function in Cryptosporidium for facilitating its virulence and pathogenesis pathway. |
| first_indexed | 2025-11-14T17:08:57Z |
| format | Article |
| id | iium-65691 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:08:57Z |
| publishDate | 2018 |
| publisher | Asian Network for Scientific Information |
| recordtype | eprints |
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| spelling | iium-656912019-06-24T08:37:29Z http://irep.iium.edu.my/65691/ Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum Barudin, Mohd Aiman Md Isa, Muhammad Lokman Mat Yusof, Afzan Q Science (General) Background and Objective: Studies on signal peptides remain little and lacking to Cryptosporidium. This study represents the first attempt to investigate selected putative protein sequences of Cryptosporidium parvum in its established genome database for signal peptide. Methods: Prediction analysis of protein sequences and identification of signal peptides on this parasite were analysed by SignalP 4.1 server. A total of 100 protein sequences were randomly selected and analysed, of which 6 (6%) corresponded to be predicted as signal peptide sequences. Results: Based on the comparison of sequences with database protein sequences in GenBank NCBI, almost all protein sequences were highly conserved with other protein sequences from different species of Cryptosporidium. Considering the secretory proteins in Cryptosporidium, several virulence protein sequences of this parasite may also show presence of N-terminal signal peptide or not. Conclusions: Hence, further studies need to be carried out for identification of N-terminal signal peptide function in Cryptosporidium for facilitating its virulence and pathogenesis pathway. Asian Network for Scientific Information 2018 Article PeerReviewed application/pdf en http://irep.iium.edu.my/65691/1/65691_Signal%20peptide%20sequence%20analysis.pdf application/pdf en http://irep.iium.edu.my/65691/2/65691_Signal%20peptide%20sequence%20analysis_SCOPUS.pdf Barudin, Mohd Aiman and Md Isa, Muhammad Lokman and Mat Yusof, Afzan (2018) Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum. Trends in Bioinformatics, 11 (1). pp. 33-43. ISSN 1994-7941 E-ISSN 2077-2254 http://docsdrive.com/pdfs/ansinet/tb/2018/33-43.pdf 10.3923/tb.2018. |
| spellingShingle | Q Science (General) Barudin, Mohd Aiman Md Isa, Muhammad Lokman Mat Yusof, Afzan Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum |
| title | Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum |
| title_full | Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum |
| title_fullStr | Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum |
| title_full_unstemmed | Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum |
| title_short | Signal peptide sequence analysis of selected protein sequences from Cryptosporidium parvum |
| title_sort | signal peptide sequence analysis of selected protein sequences from cryptosporidium parvum |
| topic | Q Science (General) |
| url | http://irep.iium.edu.my/65691/ http://irep.iium.edu.my/65691/ http://irep.iium.edu.my/65691/ http://irep.iium.edu.my/65691/1/65691_Signal%20peptide%20sequence%20analysis.pdf http://irep.iium.edu.my/65691/2/65691_Signal%20peptide%20sequence%20analysis_SCOPUS.pdf |