Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir]
Granulation of mefenamic acid particles was conducted to produce spherical shape, narrow size distribution of granules, high granule strength and good content uniformity by using Pressure Swing Granulation (PSG) technique in a fluidized bed. Two types (binderless and with binder) of granules namely...
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| Format: | Article |
| Language: | English English |
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Faculty of Science and Technology, Universiti Kebangsaan Malaysia
2018
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| Online Access: | http://irep.iium.edu.my/65533/ http://irep.iium.edu.my/65533/1/65533_GRANULATION%20OF%20MEFENAMIC%20ACID_article.pdf http://irep.iium.edu.my/65533/2/65533_GRANULATION%20OF%20MEFENAMIC%20ACID_scopus.pdf |
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| author | Ab Ghani, Salinda Abu Bakar, Noor Fitrah Abu Bakar, Mohd Rushdi Yusof, Yus Aniza Abdul Rahman, Norazah |
| author_facet | Ab Ghani, Salinda Abu Bakar, Noor Fitrah Abu Bakar, Mohd Rushdi Yusof, Yus Aniza Abdul Rahman, Norazah |
| author_sort | Ab Ghani, Salinda |
| building | IIUM Repository |
| collection | Online Access |
| description | Granulation of mefenamic acid particles was conducted to produce spherical shape, narrow size distribution of granules, high granule strength and good content uniformity by using Pressure Swing Granulation (PSG) technique in a fluidized bed. Two types (binderless and with binder) of granules namely lactose-mefenamic acid (MA) and lactose-polyethylene glycol (PEG)-(MA) with mass ratio of 30:70 and 25:5:70 were produced respectively. The later type of granules was heated for 80 ˚C, above the PEG melting point. Results indicated that all granules were uniform, spherical and narrow size distribution with the average granules size was less than 500 μm. The tensile strength of the lactose-PEG-MA was higher than the lactose-MA due to heating process. The tensile strength of lactose-PEG-MA and lactose-MA with average granules size of 500 μm were 0.42 MPa and 0.33 MPa, respectively. The drug contents in both types of granules were uniform i.e. around 70 ± 0.3 wt.%. |
| first_indexed | 2025-11-14T17:08:33Z |
| format | Article |
| id | iium-65533 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:08:33Z |
| publishDate | 2018 |
| publisher | Faculty of Science and Technology, Universiti Kebangsaan Malaysia |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-655332018-08-08T10:21:04Z http://irep.iium.edu.my/65533/ Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir] Ab Ghani, Salinda Abu Bakar, Noor Fitrah Abu Bakar, Mohd Rushdi Yusof, Yus Aniza Abdul Rahman, Norazah RS192 Materia Medica-Pharmaceutical Technology Granulation of mefenamic acid particles was conducted to produce spherical shape, narrow size distribution of granules, high granule strength and good content uniformity by using Pressure Swing Granulation (PSG) technique in a fluidized bed. Two types (binderless and with binder) of granules namely lactose-mefenamic acid (MA) and lactose-polyethylene glycol (PEG)-(MA) with mass ratio of 30:70 and 25:5:70 were produced respectively. The later type of granules was heated for 80 ˚C, above the PEG melting point. Results indicated that all granules were uniform, spherical and narrow size distribution with the average granules size was less than 500 μm. The tensile strength of the lactose-PEG-MA was higher than the lactose-MA due to heating process. The tensile strength of lactose-PEG-MA and lactose-MA with average granules size of 500 μm were 0.42 MPa and 0.33 MPa, respectively. The drug contents in both types of granules were uniform i.e. around 70 ± 0.3 wt.%. Faculty of Science and Technology, Universiti Kebangsaan Malaysia 2018-04 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/65533/1/65533_GRANULATION%20OF%20MEFENAMIC%20ACID_article.pdf application/pdf en http://irep.iium.edu.my/65533/2/65533_GRANULATION%20OF%20MEFENAMIC%20ACID_scopus.pdf Ab Ghani, Salinda and Abu Bakar, Noor Fitrah and Abu Bakar, Mohd Rushdi and Yusof, Yus Aniza and Abdul Rahman, Norazah (2018) Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir]. Malaysian Journal of Analytical Sciences, 22 (2). pp. 318-325. ISSN 1394-2506 http://www.ukm.my/mjas/v22_n2/pdf/Salinda_22_2_18.pdf 10.17576/mjas-2018-2202-18 |
| spellingShingle | RS192 Materia Medica-Pharmaceutical Technology Ab Ghani, Salinda Abu Bakar, Noor Fitrah Abu Bakar, Mohd Rushdi Yusof, Yus Aniza Abdul Rahman, Norazah Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir] |
| title | Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir] |
| title_full | Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir] |
| title_fullStr | Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir] |
| title_full_unstemmed | Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir] |
| title_short | Granulation of mefenamic acid and poly-ethylene glycol (PEG) using pressure swing granulation (psg) technique in fluidized bed [Pembentukan granul berasaskan asid mefenamik dan polietilena glikol (PEG) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir] |
| title_sort | granulation of mefenamic acid and poly-ethylene glycol (peg) using pressure swing granulation (psg) technique in fluidized bed [pembentukan granul berasaskan asid mefenamik dan polietilena glikol (peg) menggunakan teknik pengranulan tekanan terayun dalam turus terbendalir] |
| topic | RS192 Materia Medica-Pharmaceutical Technology |
| url | http://irep.iium.edu.my/65533/ http://irep.iium.edu.my/65533/ http://irep.iium.edu.my/65533/ http://irep.iium.edu.my/65533/1/65533_GRANULATION%20OF%20MEFENAMIC%20ACID_article.pdf http://irep.iium.edu.my/65533/2/65533_GRANULATION%20OF%20MEFENAMIC%20ACID_scopus.pdf |