Controlled release electrochemical synthesis and cytotoxicity study of copper(II) nanoparticles in copper(II) decanoate complex
In the present study, a controlled release electrochemical (CRE) technique based on the controlled release of Cu2+ ion from Cu anode in the presence of decanoic acid (HDe) has been used to synthesize Cu(II) decanoate (CuDe2) complex. The effect of applied voltages (1–10V) and electrolyte concentrati...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English |
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World Scientific Publishing Co. Pte Ltd
2018
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| Online Access: | http://irep.iium.edu.my/65505/ http://irep.iium.edu.my/65505/13/65505_Controlled%20Release%20Electrochemical%20Synthesis_article.pdf http://irep.iium.edu.my/65505/2/65505_Controlled%20Release%20Electrochemical%20Synthesis_scopus.pdf |
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| author | M.Nordin, Norazzizi Atiqah Samad, Wan Zurina Kardia, Egi Yahaya, Badrul Hisham Yusop, M. R. Othman, Mohamed Rozali |
| author_facet | M.Nordin, Norazzizi Atiqah Samad, Wan Zurina Kardia, Egi Yahaya, Badrul Hisham Yusop, M. R. Othman, Mohamed Rozali |
| author_sort | M.Nordin, Norazzizi Atiqah |
| building | IIUM Repository |
| collection | Online Access |
| description | In the present study, a controlled release electrochemical (CRE) technique based on the controlled release of Cu2+ ion from Cu anode in the presence of decanoic acid (HDe) has been used to synthesize Cu(II) decanoate (CuDe2) complex. The effect of applied voltages (1–10V) and electrolyte concentrations (0.1–2.0M CH3COONH4) during the electrolysis on the nanoparticles obtained was studied using TEM. The results reveal that small-sized nanoparticles (2±1nm) were obtained by using lowest applied voltage and CH3COONH4 concentration (1V and 0.1M, respectively). The smallest nanoparticle obtained was then used in the cytotoxicity study against A549 and HeLa cells. The synthesized complex gives moderate cytotoxic effect on the selected cells (IC50=15.85μM and 20.89μM, respectively) and low cytotoxic effect on normal cells (IMR90). Apoptosis is the mode of cell death based on the apoptosis assay that has been conducted. |
| first_indexed | 2025-11-14T17:08:26Z |
| format | Article |
| id | iium-65505 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:08:26Z |
| publishDate | 2018 |
| publisher | World Scientific Publishing Co. Pte Ltd |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-655052018-08-09T02:22:02Z http://irep.iium.edu.my/65505/ Controlled release electrochemical synthesis and cytotoxicity study of copper(II) nanoparticles in copper(II) decanoate complex M.Nordin, Norazzizi Atiqah Samad, Wan Zurina Kardia, Egi Yahaya, Badrul Hisham Yusop, M. R. Othman, Mohamed Rozali QC Physics QD Chemistry QP Physiology In the present study, a controlled release electrochemical (CRE) technique based on the controlled release of Cu2+ ion from Cu anode in the presence of decanoic acid (HDe) has been used to synthesize Cu(II) decanoate (CuDe2) complex. The effect of applied voltages (1–10V) and electrolyte concentrations (0.1–2.0M CH3COONH4) during the electrolysis on the nanoparticles obtained was studied using TEM. The results reveal that small-sized nanoparticles (2±1nm) were obtained by using lowest applied voltage and CH3COONH4 concentration (1V and 0.1M, respectively). The smallest nanoparticle obtained was then used in the cytotoxicity study against A549 and HeLa cells. The synthesized complex gives moderate cytotoxic effect on the selected cells (IC50=15.85μM and 20.89μM, respectively) and low cytotoxic effect on normal cells (IMR90). Apoptosis is the mode of cell death based on the apoptosis assay that has been conducted. World Scientific Publishing Co. Pte Ltd 2018-05-01 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/65505/13/65505_Controlled%20Release%20Electrochemical%20Synthesis_article.pdf application/pdf en http://irep.iium.edu.my/65505/2/65505_Controlled%20Release%20Electrochemical%20Synthesis_scopus.pdf M.Nordin, Norazzizi Atiqah and Samad, Wan Zurina and Kardia, Egi and Yahaya, Badrul Hisham and Yusop, M. R. and Othman, Mohamed Rozali (2018) Controlled release electrochemical synthesis and cytotoxicity study of copper(II) nanoparticles in copper(II) decanoate complex. Nano, 13 (5). 1850048-1-1850048-14. ISSN 1793-2920 https://www.worldscientific.com/doi/pdf/10.1142/S1793292018500480 10.1142/S1793292018500480 |
| spellingShingle | QC Physics QD Chemistry QP Physiology M.Nordin, Norazzizi Atiqah Samad, Wan Zurina Kardia, Egi Yahaya, Badrul Hisham Yusop, M. R. Othman, Mohamed Rozali Controlled release electrochemical synthesis and cytotoxicity study of copper(II) nanoparticles in copper(II) decanoate complex |
| title | Controlled release electrochemical synthesis and cytotoxicity study of copper(II) nanoparticles in copper(II) decanoate complex |
| title_full | Controlled release electrochemical synthesis and cytotoxicity study of copper(II) nanoparticles in copper(II) decanoate complex |
| title_fullStr | Controlled release electrochemical synthesis and cytotoxicity study of copper(II) nanoparticles in copper(II) decanoate complex |
| title_full_unstemmed | Controlled release electrochemical synthesis and cytotoxicity study of copper(II) nanoparticles in copper(II) decanoate complex |
| title_short | Controlled release electrochemical synthesis and cytotoxicity study of copper(II) nanoparticles in copper(II) decanoate complex |
| title_sort | controlled release electrochemical synthesis and cytotoxicity study of copper(ii) nanoparticles in copper(ii) decanoate complex |
| topic | QC Physics QD Chemistry QP Physiology |
| url | http://irep.iium.edu.my/65505/ http://irep.iium.edu.my/65505/ http://irep.iium.edu.my/65505/ http://irep.iium.edu.my/65505/13/65505_Controlled%20Release%20Electrochemical%20Synthesis_article.pdf http://irep.iium.edu.my/65505/2/65505_Controlled%20Release%20Electrochemical%20Synthesis_scopus.pdf |