Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

QR Code

Global metabolic analyses identify key differences in metabolite levels between polymyxin-susceptible and polymyxin-resistant Acinetobacter baumannii

Multidrug-resistant Acinetobacter baumannii presents a global medical crisis and polymyxins are used as the last-line therapy. This study aimed to identify metabolic differences between polymyxinsusceptible and polymyxin-resistant A. baumannii using untargeted metabolomics. The metabolome of each...

Full description

Bibliographic Details
Main Authors:	Mahamad Maifiah, Mohd Hafidz, Cheah, Soon-Ee, Johnson, Matthew D., Han, Mei-Ling, Boyce, John D., Thamlikitkul, Visanu, Forrest, Alan, Kaye, Keith S., Hertzog, Paul, Purcell, Anthony W., Song, Jiangning, Velkov, Tony, Creek, Darren J., Li, Jian
Format:	Article
Language:	English
Published:	Springer Nature 2016
Subjects:	QR Microbiology RM Therapeutics. Pharmacology RM300 Drugs and their action
Online Access:	http://irep.iium.edu.my/65378/ http://irep.iium.edu.my/65378/1/2016_SciRep.pdf

Similar Items

Metabolic responses to polymyxin treatment in acinetobacter baumannii ATCC 19606: integrating transcriptomics and metabolomics with genome-scale metabolic modeling
by: Zhu, Yan, et al.
Published: (2019)

Global metabolic analyses of acinetobacter baumannii
by: Mahamad Maifiah, Mohd Hafidz, et al.
Published: (2019)

Genome-scale metabolic modeling of responses to polymyxins in Pseudomonas aeruginosa
by: Zhu, Yan, et al.
Published: (2018)

Untargeted metabolomics analysis reveals key pathways responsible for the synergistic killing of colistin and doripenem combination against Acinetobacter baumannii
by: Mahamad Maifiah, Mohd Hafidz, et al.
Published: (2017)

Revisiting an ‘old’ antibiotic class polymyxins by drug combination therapy targeting Gram-negative superbugs: Toyyiban perspective
by: Mahamad Maifiah, Mohd Hafidz, et al.
Published: (2019)

Treatment outcomes of patients with acinetobacter infection : comparison between polymyxin versus non polymyxin based therapy
by: Jeeawoody, Aakil
Published: (2019)

Genome sequence of Acinetobacter baumannii AC12, a polymyxin-resistant strain isolated from Terengganu, Malaysia

Comparative genomics of two ST 195 carbapenem-resistant Acinetobacter baumannii with different susceptibility to polymyxin revealed underlying resistance mechanism

Imprinted contact lenses for sustained release of polymyxin B and related antimicrobial peptides
by: Malakooti, Negin, et al.
Published: (2015)

Pharmacodynamics of colistin against Acinetobacter baumannii
by: Mohd Rasidin, Rashizal Sazli
Published: (2017)

Divalent cations (Mg2+, Ca2+) protect bacterial outer membrane damage by polymyxin B
by: Ahmad Zorin Sahalan,, et al.
Published: (2013)

Prevalence and antibiotic resistance profiles of Acinetobacter baumannii and non-baumannii Acinetobacters from a tertiary hospital in Terengganu, Malaysia

Quorum sensing and surface attachment in Acinetobacter baumannii
by: Lopez Martin, Mario
Published: (2020)

Metabolite profiling of Clinacanthus nutans leaves extracts obtained from different drying methods by 1H NMR-based metabolomics
by: Noor Hashim, Noor Haslinda, et al.
Published: (2016)

Polymyxin b therapy for multidrug resistant gram negative infections : outcome and risk factors for treatment failure in critical care
by: Ismail, Bahiah
Published: (2015)

Demonstration Of Antigenic And Specific Outer Membrane Protein(S) Of Acinetobacter Baumannii
by: Shafiqul Islam, A.H.M.
Published: (2009)

Simulation of Transdermal Drug Delivery System for Breast Cancer Therapy Using COMSOL
by: Muhammad Hafidz Idham, Salahuddin
Published: (2012)

Demonstration of antigenic and specific surface association heat shock protein(s) of acinetobacter baumannii
by: Hasnur, Nur Nadhra Adila
Published: (2018)

Inhibition of microlax- Induced experimental diarrhoea with narcotic like-extracts of psidium guajava leaf in rats
by: Lutterodt, George D.
Published: (1999)

Assessment of lipid-lowering therapy prescribing among patients with type 2 Diabetes Mellitus in Malaysian primary care settings
by: Elnaem, Mohamed Hassan Abdelaziz, et al.
Published: (2017)

Effects of pioglitazone therapy on hepatic fatty acid synthesis, beta-oxidation and hepatic stellate cells: is the drug more than an insulin sanitizer
by: Abdul Rahim, Roslina, et al.
Published: (2009)

The application of the theory of planned behavior to understand the intention of weight loss practice among overweight adolescentS
by: Sidek, Suriati, et al.
Published: (2016)

Delineating the plausible molecular vaccine candidates and drug targets of multidrug-resistant Acinetobacter baumannii
by: Mujawar, Shama *, et al.
Published: (2019)

Phenotypic and molecular characterisation of clinical carbapenem-resistant acinetobacter baumannii / Kong Boon Hong
by: Kong, Boon Hong
Published: (2012)

Acinetobacter baumannii strain 6.1 16S ribosomal RNA gene, partial sequence
by: Kamarudin, Kamarul Rahim, et al.
Published: (2012)

The mazEF toxin-antitoxin system as a novel antibacterial target in Acinetobacter baumannii
by: Ghafourian, Sobhan, et al.
Published: (2014)

Characterization and identification of newly isolated Acinetobacter baumannii strain Serdang 1 for phenol removal
by: Mohamad Yadzir, Zailatul Hani, et al.
Published: (2012)

Occurrence of multidrug-resistant Acinetobacter baumannii and Escherichia coli in veterinary health care facilities
by: Ng, Joanna Sze Yi
Published: (2015)

The characterisation of carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae in a teaching hospital in Malaysia
by: Lau, Min Yi, et al.
Published: (2024)

Small, Enigmatic Plasmids of the Nosocomial Pathogen, Acinetobacter baumannii: Good, Bad, Who Knows?

Resistance Island: What is new in an Extensive-Drug Resistant Clinical Strain of Acinetobacter baumannii?

Prescribing of Strong Opioid Analgesics by UK Primary Care Physicians from 2000 to 2010
by: Zin, Che Suraya, et al.
Published: (2012)

The Effects of Low-Dose Non-ionizing and Ionizing Radiation on Wound Healing and Cancer
by: Raahilah, Z. E., et al.
Published: (2022)

Paediatric effective radiation doses during brain computed tomography angiography procedure
by: Salah, H., et al.
Published: (2023)

Arborinine from Glycosmis Pentaphylla (retz.) DC induces apoptosis through activation of Caspase-3/7 in human mammary gland Adenocarcinoma (MCF-7) cell line
by: Mohd Hussain, Nurlaili Najmie, et al.
Published: (2016)

Lysophosphatidylinositol: a novel link between ABC transporters and G-protein-coupled receptors
by: Ruban, Emily L., et al.
Published: (2014)

Are physicians and clinical pharmacists aware and knowledgeable enough about inappropriate prescribing for elderly patients? Findings from Malaysia
by: Akkawi, Muhammad Eid, et al.
Published: (2018)

Non-neurotoxic activity of Malayan krait (Bungarus candidus) venom from Thailand
by: Charoenpitakchai, Mongkon, et al.
Published: (2018)

Studies on the red sea sponge Haliclona sp. for its chemical and cytotoxic properties
by: Al-Massarani, Shaza Mohamed, et al.
Published: (2016)

Patterns of initial opioid prescribing and its association with short and long-term use among opioid naïve patients: Experience from Malaysia
by: Zin, Che Suraya, et al.
Published: (2018)