Novel quinazoline-based sulfonamide derivative (3D) induces apoptosis in colorectal cancer by inhibiting JAK2–STAT3 pathway
Introduction: Colorectal cancer (CRC) is a major worldwide health problem owing to its high prevalence and mortality rate. Developments in screening, prevention, biomarker, personalized therapies and chemotherapy have improved detection and treatment. However, despite these advances, many patient...
| Main Authors: | Al-Obeed, Omar A., Vaali-Mohammed, Mansoor-Ali, Eldehna, Wagdy M, Al-Khayal, Khayal A., Mahmood, Amer A., Abdel-Aziz, Hatem A, Zubaidi, Ahmed, Alafeefy, Ahmed Mahmoud, Abdulla, Maha Hamadien, Ahmad, Rehan |
|---|---|
| Format: | Article |
| Language: | English English English |
| Published: |
Dove Press
2018
|
| Subjects: | |
| Online Access: | http://irep.iium.edu.my/64779/ http://irep.iium.edu.my/64779/1/64779-Novel%20quinazoline-based.pdf http://irep.iium.edu.my/64779/2/64779-Novel%20quinazoline-based%20SCOPUS.pdf http://irep.iium.edu.my/64779/13/64779_Novel%20quinazoline-based%20sulfonamide%20derivative%20%283D%29%20induces%20apoptosis%20in%20colorectal%20cancer%20by%20inhibiting%20JAK2-STAT3%20pathway_WOS.pdf |
Similar Items
Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through
ROS generation and inhibits cell migration
by: Al-Khayal, Khayal A., et al.
Published: (2017)
by: Al-Khayal, Khayal A., et al.
Published: (2017)
Development of certain new 2-substituted-quinazolin-4-yl-aminobenzenesulfonamide as potential antitumor agents
by: Alafeefy, Ahmed Mahmoud, et al.
Published: (2016)
by: Alafeefy, Ahmed Mahmoud, et al.
Published: (2016)
Synthesis and evaluation of anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities of some 3H-quinazolin-4-one derivatives
by: El-Sayed, Nahed Nasser Eid, et al.
Published: (2019)
by: El-Sayed, Nahed Nasser Eid, et al.
Published: (2019)
Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma
by: Sibbesen, Nina A., et al.
Published: (2015)
by: Sibbesen, Nina A., et al.
Published: (2015)
Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties
by: Bozdag, Murat, et al.
Published: (2016)
by: Bozdag, Murat, et al.
Published: (2016)
Development of certain novel N-(2-(2-(2-oxoindolin-3-ylidene)hydrazinecarbonyl)phenyl)-benzamides and 3-(2-oxoindolin-3-ylideneamino)-2-substituted quinazolin-4(3H)-ones as CFM-1 analogs: design, synthesis, QSAR analysis and anticancer activity.
by: Alafeefy, Ahmed M., et al.
Published: (2015)
by: Alafeefy, Ahmed M., et al.
Published: (2015)
Novel quinazoline and acetamide derivatives as safe anti-ulcerogenic agent and anti-ulcerative colitis activity
by: Alasmary, Fatmah A.S., et al.
Published: (2018)
by: Alasmary, Fatmah A.S., et al.
Published: (2018)
Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-ß-catenin-mediated intestinal tumor growth and regeneration
by: Phesse, T., et al.
Published: (2014)
by: Phesse, T., et al.
Published: (2014)
Synthesis of new 3-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-benzenesulfonamides with strong inhibition properties against the tumor associated carbonic anhydrases IX and XII
by: Bozdag, Murat, et al.
Published: (2017)
by: Bozdag, Murat, et al.
Published: (2017)
Potential role of JAK-STAT signaling pathway in the neurogenic-to-gliogenic shift in down syndrome brain
by: Lee, Han Chung, et al.
Published: (2016)
by: Lee, Han Chung, et al.
Published: (2016)
Celastrol suppresses growth and induces apoptosis of human hepatocellular carcinoma through the modulation of STAT3/JAK2 signaling cascade In Vitro and In Vivo
by: Rajendran, P., et al.
Published: (2012)
by: Rajendran, P., et al.
Published: (2012)
The role of JAK-STAT signalling in the developing brain of Ts1Cje mouse model for Down syndrome
by: Lee, Han Chung, et al.
Published: (2015)
by: Lee, Han Chung, et al.
Published: (2015)
REST targets JAK–STAT and HIF-1 signaling pathways in human Down syndrome brain and neural cells
by: Huang, Tan, et al.
Published: (2023)
by: Huang, Tan, et al.
Published: (2023)
Novel sulfonamide derivatives carrying a biologically active 3,4-dimethoxyphenyl moiety as VEGFR-2 inhibitors
by: Ghorab, Mostafa Mohammed, et al.
Published: (2016)
by: Ghorab, Mostafa Mohammed, et al.
Published: (2016)
Unphosphorylated dimers are not required for the assembly of
active STAT1 and STAT3 homo-and heterodimers
by: Krause, Sebastian C.
Published: (2023)
by: Krause, Sebastian C.
Published: (2023)
Polyphenols mitigating inflammatory mechanisms in Inflammatory Bowel Disease (IBD): focus on NF-κB and JAK/STAT pathways
by: Ismail, Elysha Nur, et al.
Published: (2024)
by: Ismail, Elysha Nur, et al.
Published: (2024)
The mechanism of action of the negative
Regulators of jak/stat singnaling pathway in
Resistant FLT-ITD acute myeloid leukaemia cells
by: Johan, Muhammad Farid
Published: (2019)
by: Johan, Muhammad Farid
Published: (2019)
An azaspirane derivative suppresses growth and induces apoptosis of ER-positive and ER-negative breast cancer cells through the modulation of JAK2/STAT3 signaling pathway
by: Sulaiman, N., et al.
Published: (2016)
by: Sulaiman, N., et al.
Published: (2016)
Acquired radioresistance in EMT6 mouse mammary carcinoma cell line is mediated by CTLA-4 and PD-1 throughJAK/STAT/PI3K pathway
by: Ronny Sham, Nur Fatihah, et al.
Published: (2023)
by: Ronny Sham, Nur Fatihah, et al.
Published: (2023)
Gene and protein expression profiles of JAK-STAT signalling pathway in the developing brain of the Ts1Cje down syndrome mouse model
by: Lee, Han Chung, et al.
Published: (2019)
by: Lee, Han Chung, et al.
Published: (2019)
Exogenous dihydrosphingosine 1 phosphate mediates collagen synthesis in cardiac fibroblasts through JAK/STAT signalling and regulation of TIMP1
by: Magaye, R.R., et al.
Published: (2020)
by: Magaye, R.R., et al.
Published: (2020)
The STAT3-Ser/Hes3 signaling axis in cancer
by: Poser, Steven, et al.
Published: (2014)
by: Poser, Steven, et al.
Published: (2014)
Ubiquitous occurrence of sulfonamides in tropical Asian waters.
by: Shimizu, Akiko, et al.
Published: (2013)
by: Shimizu, Akiko, et al.
Published: (2013)
Regulation of TNF-α and NF-κB activation through the JAK/STAT signaling pathway downstream of histamine 4 receptor in a rat model of LPS-induced joint inflammation.
by: Ahmad, Sheikh Fayaz, et al.
Published: (2015)
by: Ahmad, Sheikh Fayaz, et al.
Published: (2015)
Targeting transcription factor STAT3 for cancer prevention and therapy.
by: Chai, E., et al.
Published: (2015)
by: Chai, E., et al.
Published: (2015)
Do STAT3 inhibitors have potential in the future for cancer therapy?
by: Wong, A., et al.
Published: (2017)
by: Wong, A., et al.
Published: (2017)
Sulfonamides determination in chicken meat products from Malaysia
by: Cheong, C. K., et al.
Published: (2010)
by: Cheong, C. K., et al.
Published: (2010)
Simple synthesis of 2-amino-4-(het)aryl-4,6-dihydro-1(3)(11)H-[1,3,5]triazino[2,1-b]quinazolin-6-ones
by: Dolzhenko, Anton, et al.
Published: (2008)
by: Dolzhenko, Anton, et al.
Published: (2008)
STAT3-Ser/Hes3 signaling: a new molecular component of the neuroendocrine system?
by: Nikolakopoulou, P., et al.
Published: (2016)
by: Nikolakopoulou, P., et al.
Published: (2016)
STAT3-mediated regulation of oxidative-stress responsive genes
by: Grillo, Michela
Published: (2020)
by: Grillo, Michela
Published: (2020)
Targeting the STAT3 signaling pathway in cancer: Role of synthetic and natural inhibitors
by: Siveen, K., et al.
Published: (2013)
by: Siveen, K., et al.
Published: (2013)
A Traceability System for Sulfonamide Residues in Chicken Meat-Balls
by: Mohammad Rashedi, Ismail Fitry
Published: (2008)
by: Mohammad Rashedi, Ismail Fitry
Published: (2008)
A novel synthesis of anti-cancer drug gefitinib from 6,7-dimethoxy-3H-quinazolin-4-one
by: Santoso, Prio, et al.
Published: (2025)
by: Santoso, Prio, et al.
Published: (2025)
Overexpression of Bcl-2 induces STAT-3 activation via an increase in mitochondrial superoxide.
by: Kang, J., et al.
Published: (2015)
by: Kang, J., et al.
Published: (2015)
The effect of hypoxia and reoxygenation on STAT3 regulation in potential cardiomyocyte models
by: Evans, Emma Louise
Published: (2012)
by: Evans, Emma Louise
Published: (2012)
Functional Evaluation Of Flag-Stat1 In U3A Cells
by: Tey, Lee Hung
Published: (2017)
by: Tey, Lee Hung
Published: (2017)
The role of signal transducer and activator of transcription 3 (STAT3) and its targeted inhibition in hematological malignancies
by: Arora, L., et al.
Published: (2018)
by: Arora, L., et al.
Published: (2018)
Gene aberrations and methylation analysis of JAK/stat and toll-like receptor downstream signalling in BCR-ABL-negative myeloproliferative neoplasms and myelodysplastic syndrome/myeloproliferative neoplasms overlap syndromes
by: Cai, Chia Yuh
Published: (2021)
by: Cai, Chia Yuh
Published: (2021)
JAK 343 Kimia Koordinatan
by: PPJJ, Pusat Pengajian Jarak Jauh
Published: (1991)
by: PPJJ, Pusat Pengajian Jarak Jauh
Published: (1991)
JAK 231 - Kimia Takorganik
by: PPJJ, Pusat Pengajian Jarak Jauh
Published: (1992)
by: PPJJ, Pusat Pengajian Jarak Jauh
Published: (1992)
Similar Items
-
Novel derivative of aminobenzenesulfonamide (3c) induces apoptosis in colorectal cancer cells through
ROS generation and inhibits cell migration
by: Al-Khayal, Khayal A., et al.
Published: (2017) -
Development of certain new 2-substituted-quinazolin-4-yl-aminobenzenesulfonamide as potential antitumor agents
by: Alafeefy, Ahmed Mahmoud, et al.
Published: (2016) -
Synthesis and evaluation of anticancer, antiphospholipases, antiproteases, and antimetabolic syndrome activities of some 3H-quinazolin-4-one derivatives
by: El-Sayed, Nahed Nasser Eid, et al.
Published: (2019) -
Jak3, STAT3, and STAT5 inhibit expression of miR-22, a novel tumor suppressor microRNA, in cutaneous T-Cell lymphoma
by: Sibbesen, Nina A., et al.
Published: (2015) -
Synthesis 4-[2-(2-mercapto-4-oxo-4H-quinazolin-3-yl)-ethyl]-benzenesulfonamides with subnanomolar carbonic anhydrase II and XII inhibitory properties
by: Bozdag, Murat, et al.
Published: (2016)