Incorporation of the microencapsulated antimicrobial agent phytoncide into denture base resin
Background This study aimed to fabricate a denture base resin (DBR) containing phytoncide microcapsules (PTMCs) and determine the mechanical properties of the resin and antifungal activity. Methods Fifty‐four heat cured rectangular DBR specimens (64 x 10 x 3.3 ± 0.2 mm) containing nine concentr...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English English English |
| Published: |
Wiley Online Library
2018
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| Online Access: | http://irep.iium.edu.my/64442/ http://irep.iium.edu.my/64442/7/64442_Incorporation%20of%20the%20microencapsulated%20antimicrobial_SCOPUS.pdf http://irep.iium.edu.my/64442/19/64442_Incorporation%20of%20the%20microencapsulated%20antimicrobial.pdf http://irep.iium.edu.my/64442/20/64442_Incorporation%20of%20the%20microencapsulated%20antimicrobial_WOS.pdf |
| _version_ | 1848786216820932608 |
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| author | Steve, An Judge, Roy B Wong, Rebecca H Arzmi, Mohd Hafiz Palamara, J E Dashper, Stuart |
| author_facet | Steve, An Judge, Roy B Wong, Rebecca H Arzmi, Mohd Hafiz Palamara, J E Dashper, Stuart |
| author_sort | Steve, An |
| building | IIUM Repository |
| collection | Online Access |
| description | Background
This study aimed to fabricate a denture base resin (DBR) containing phytoncide microcapsules (PTMCs) and determine the mechanical properties of the resin and antifungal activity.
Methods
Fifty‐four heat cured rectangular DBR specimens (64 x 10 x 3.3 ± 0.2 mm) containing nine concentrations of PTMC between 0 ‐ 5% (wt/wt) were fabricated and subjected to a three‐point bending test. A phytoncide release bioassay was developed using DBR containing 0% and 2.5% PTMCs (wt/wt) in a 24 well‐plate assay with incubation of Porphyromonas gingivalis at 37°C for 74 h. The antifungal activity of PTMCs against Candida albicans, in a pH 5.5 acidic environment was determined in a plate assay.
Results
Flexural strength decreased with increasing PTMC concentration from 97.58 ± 4.79 MPa for the DBR alone to 53.66 ± 2.46 MPa for DBR containing 5.0% PTMC. No release of phytoncide from the PTMCs in the DBR was detected at pH 7.4. The PTMCs had a minimal inhibitory concentration of 2.6% (wt/vol) against C. albicans at pH 5.5.
Conclusions
PTMCs can be added to DBR 2.5% (wt/wt) without adversely affecting flexural strength. PTMCs released the antimicrobial agent at pH 5.5 at concentrations sufficient to inhibit the growth of the C. albicans. |
| first_indexed | 2025-11-14T17:05:31Z |
| format | Article |
| id | iium-64442 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English English |
| last_indexed | 2025-11-14T17:05:31Z |
| publishDate | 2018 |
| publisher | Wiley Online Library |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-644422019-01-31T06:38:10Z http://irep.iium.edu.my/64442/ Incorporation of the microencapsulated antimicrobial agent phytoncide into denture base resin Steve, An Judge, Roy B Wong, Rebecca H Arzmi, Mohd Hafiz Palamara, J E Dashper, Stuart QR Microbiology RK Dentistry Background This study aimed to fabricate a denture base resin (DBR) containing phytoncide microcapsules (PTMCs) and determine the mechanical properties of the resin and antifungal activity. Methods Fifty‐four heat cured rectangular DBR specimens (64 x 10 x 3.3 ± 0.2 mm) containing nine concentrations of PTMC between 0 ‐ 5% (wt/wt) were fabricated and subjected to a three‐point bending test. A phytoncide release bioassay was developed using DBR containing 0% and 2.5% PTMCs (wt/wt) in a 24 well‐plate assay with incubation of Porphyromonas gingivalis at 37°C for 74 h. The antifungal activity of PTMCs against Candida albicans, in a pH 5.5 acidic environment was determined in a plate assay. Results Flexural strength decreased with increasing PTMC concentration from 97.58 ± 4.79 MPa for the DBR alone to 53.66 ± 2.46 MPa for DBR containing 5.0% PTMC. No release of phytoncide from the PTMCs in the DBR was detected at pH 7.4. The PTMCs had a minimal inhibitory concentration of 2.6% (wt/vol) against C. albicans at pH 5.5. Conclusions PTMCs can be added to DBR 2.5% (wt/wt) without adversely affecting flexural strength. PTMCs released the antimicrobial agent at pH 5.5 at concentrations sufficient to inhibit the growth of the C. albicans. Wiley Online Library 2018-06 Article NonPeerReviewed application/pdf en http://irep.iium.edu.my/64442/7/64442_Incorporation%20of%20the%20microencapsulated%20antimicrobial_SCOPUS.pdf application/pdf en http://irep.iium.edu.my/64442/19/64442_Incorporation%20of%20the%20microencapsulated%20antimicrobial.pdf application/pdf en http://irep.iium.edu.my/64442/20/64442_Incorporation%20of%20the%20microencapsulated%20antimicrobial_WOS.pdf Steve, An and Judge, Roy B and Wong, Rebecca H and Arzmi, Mohd Hafiz and Palamara, J E and Dashper, Stuart (2018) Incorporation of the microencapsulated antimicrobial agent phytoncide into denture base resin. Australian Dental Journal, 63 (3). pp. 302-311. ISSN 1834-7819 https://onlinelibrary.wiley.com/doi/pdf/10.1111/adj.12640 10.1111/adj.12640 |
| spellingShingle | QR Microbiology RK Dentistry Steve, An Judge, Roy B Wong, Rebecca H Arzmi, Mohd Hafiz Palamara, J E Dashper, Stuart Incorporation of the microencapsulated antimicrobial agent phytoncide into denture base resin |
| title | Incorporation of the microencapsulated antimicrobial agent phytoncide into denture base resin |
| title_full | Incorporation of the microencapsulated antimicrobial agent phytoncide into denture base resin |
| title_fullStr | Incorporation of the microencapsulated antimicrobial agent phytoncide into denture base resin |
| title_full_unstemmed | Incorporation of the microencapsulated antimicrobial agent phytoncide into denture base resin |
| title_short | Incorporation of the microencapsulated antimicrobial agent phytoncide into denture base resin |
| title_sort | incorporation of the microencapsulated antimicrobial agent phytoncide into denture base resin |
| topic | QR Microbiology RK Dentistry |
| url | http://irep.iium.edu.my/64442/ http://irep.iium.edu.my/64442/ http://irep.iium.edu.my/64442/ http://irep.iium.edu.my/64442/7/64442_Incorporation%20of%20the%20microencapsulated%20antimicrobial_SCOPUS.pdf http://irep.iium.edu.my/64442/19/64442_Incorporation%20of%20the%20microencapsulated%20antimicrobial.pdf http://irep.iium.edu.my/64442/20/64442_Incorporation%20of%20the%20microencapsulated%20antimicrobial_WOS.pdf |