Blood glucose and sepsis score on sepsis patients requiring insulin therapy
Early treatment of sepsis is crucial in improving the patient condition and reduces mortality. The lack of information and methods to diagnose sepsis at an early stage is a significant barrier to early treatment. Treatment is normally based on clinical judgment since blood cultures are negative in t...
| Main Authors: | , , , , , , |
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| Format: | Proceeding Paper |
| Language: | English English |
| Published: |
Springer Verlag
2018
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| Online Access: | http://irep.iium.edu.my/64061/ http://irep.iium.edu.my/64061/1/64061_Blood%20glucose%20and%20sepsis%20score%20on%20sepsis%20patients%20requiring_article.pdf http://irep.iium.edu.my/64061/2/64061_Blood%20glucose%20and%20sepsis%20score%20on%20sepsis%20patients%20requiring_scopus.pdf |
| _version_ | 1848786140518154240 |
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| author | Mohamad Suhaimi, Fatanah Jamaludin, Ummu Kulthum Abdul Razak, Normy Norfiza Pretty, Christopher G. Md Ralib, Azrina Mat Nor, Mohd Basri Dzaharudin, Fatimah |
| author_facet | Mohamad Suhaimi, Fatanah Jamaludin, Ummu Kulthum Abdul Razak, Normy Norfiza Pretty, Christopher G. Md Ralib, Azrina Mat Nor, Mohd Basri Dzaharudin, Fatimah |
| author_sort | Mohamad Suhaimi, Fatanah |
| building | IIUM Repository |
| collection | Online Access |
| description | Early treatment of sepsis is crucial in improving the patient condition and reduces mortality. The lack of information and methods to diagnose sepsis at an early stage is a significant barrier to early treatment. Treatment is normally based on clinical judgment since blood cultures are negative in the majority of sepsis or septic shock cases as reported in several studies. Even with blood cultures result, a delay in diagnosis may happen while waiting for the results. Therefore, clinical guidelines are still required to provide guidance for the clinician caring for a patient with severe sepsis or septic shock. In this study, a validated glucose-insulin model is used to capture patient-specific insulin sensitivity profile. The validated model is incorporated with a sepsis system to create a glucose-insulin model that describe sepsis occurrence. The relationship between insulin sensitivity, blood glucose and sepsis score is investigated using a retrospective data of 8 patients admitted in the Tengku Ampuan Afzan Hospital, Kuantan. Results indicate that there was a significant relationship between blood glucose level and sepsis score (p < 0.001), and insulin sensitivity with a sepsis score (p < 0.001). Additionally, blood glucose level was higher in a severe sepsis group compared to the non-sepsis group. Whereas, insulin sensitivity is lower in a severe sepsis group. Insulin sensitivity profile can be incorporated with the sepsis system for monitoring sepsis patients requiring insulin therapy as seen in this study. Thus, the sepsis glucose-insulin model can potentially be used as an indicator or tools for sepsis diagnosis. |
| first_indexed | 2025-11-14T17:04:18Z |
| format | Proceeding Paper |
| id | iium-64061 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English English |
| last_indexed | 2025-11-14T17:04:18Z |
| publishDate | 2018 |
| publisher | Springer Verlag |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-640612018-07-10T07:54:59Z http://irep.iium.edu.my/64061/ Blood glucose and sepsis score on sepsis patients requiring insulin therapy Mohamad Suhaimi, Fatanah Jamaludin, Ummu Kulthum Abdul Razak, Normy Norfiza Pretty, Christopher G. Md Ralib, Azrina Mat Nor, Mohd Basri Dzaharudin, Fatimah RA Public aspects of medicine RC Internal medicine RC111 Infectious and Parasitic Diseases Early treatment of sepsis is crucial in improving the patient condition and reduces mortality. The lack of information and methods to diagnose sepsis at an early stage is a significant barrier to early treatment. Treatment is normally based on clinical judgment since blood cultures are negative in the majority of sepsis or septic shock cases as reported in several studies. Even with blood cultures result, a delay in diagnosis may happen while waiting for the results. Therefore, clinical guidelines are still required to provide guidance for the clinician caring for a patient with severe sepsis or septic shock. In this study, a validated glucose-insulin model is used to capture patient-specific insulin sensitivity profile. The validated model is incorporated with a sepsis system to create a glucose-insulin model that describe sepsis occurrence. The relationship between insulin sensitivity, blood glucose and sepsis score is investigated using a retrospective data of 8 patients admitted in the Tengku Ampuan Afzan Hospital, Kuantan. Results indicate that there was a significant relationship between blood glucose level and sepsis score (p < 0.001), and insulin sensitivity with a sepsis score (p < 0.001). Additionally, blood glucose level was higher in a severe sepsis group compared to the non-sepsis group. Whereas, insulin sensitivity is lower in a severe sepsis group. Insulin sensitivity profile can be incorporated with the sepsis system for monitoring sepsis patients requiring insulin therapy as seen in this study. Thus, the sepsis glucose-insulin model can potentially be used as an indicator or tools for sepsis diagnosis. Springer Verlag 2018 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/64061/1/64061_Blood%20glucose%20and%20sepsis%20score%20on%20sepsis%20patients%20requiring_article.pdf application/pdf en http://irep.iium.edu.my/64061/2/64061_Blood%20glucose%20and%20sepsis%20score%20on%20sepsis%20patients%20requiring_scopus.pdf Mohamad Suhaimi, Fatanah and Jamaludin, Ummu Kulthum and Abdul Razak, Normy Norfiza and Pretty, Christopher G. and Md Ralib, Azrina and Mat Nor, Mohd Basri and Dzaharudin, Fatimah (2018) Blood glucose and sepsis score on sepsis patients requiring insulin therapy. In: 2nd International Conference for Innovation in Biomedical Engineering and Life Sciences, ICIBEL 2017, 10-13 December 2017, Penang; Malaysia. https://link.springer.com/chapter/10.1007%2F978-981-10-7554-4_46 10.1007/978-981-10-7554-4_46 |
| spellingShingle | RA Public aspects of medicine RC Internal medicine RC111 Infectious and Parasitic Diseases Mohamad Suhaimi, Fatanah Jamaludin, Ummu Kulthum Abdul Razak, Normy Norfiza Pretty, Christopher G. Md Ralib, Azrina Mat Nor, Mohd Basri Dzaharudin, Fatimah Blood glucose and sepsis score on sepsis patients requiring insulin therapy |
| title | Blood glucose and sepsis score on sepsis patients requiring insulin therapy |
| title_full | Blood glucose and sepsis score on sepsis patients requiring insulin therapy |
| title_fullStr | Blood glucose and sepsis score on sepsis patients requiring insulin therapy |
| title_full_unstemmed | Blood glucose and sepsis score on sepsis patients requiring insulin therapy |
| title_short | Blood glucose and sepsis score on sepsis patients requiring insulin therapy |
| title_sort | blood glucose and sepsis score on sepsis patients requiring insulin therapy |
| topic | RA Public aspects of medicine RC Internal medicine RC111 Infectious and Parasitic Diseases |
| url | http://irep.iium.edu.my/64061/ http://irep.iium.edu.my/64061/ http://irep.iium.edu.my/64061/ http://irep.iium.edu.my/64061/1/64061_Blood%20glucose%20and%20sepsis%20score%20on%20sepsis%20patients%20requiring_article.pdf http://irep.iium.edu.my/64061/2/64061_Blood%20glucose%20and%20sepsis%20score%20on%20sepsis%20patients%20requiring_scopus.pdf |