Identification of MSX1 mutation in Malaysian hypodontia family
Hypodontia is defined as the absence of one to six teeth. There is high prevalence of hypodontia recorded in Malaysia (2.8%). This study aimed to identify any mutation of MSX1 in Malaysian family with hypodontia and its clinical finding. We re-examined 4 individuals from a family of the previou...
| Main Authors: | , , , |
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| Format: | Proceeding Paper |
| Language: | English |
| Published: |
Atlantis Press
2018
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| Subjects: | |
| Online Access: | http://irep.iium.edu.my/63481/ http://irep.iium.edu.my/63481/1/63841_Identification%20of%20MSX1%20mutation%20in%20Malaysian%20hypodontia%20family.pdf |
| _version_ | 1848786040502878208 |
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| author | Muhamad Zamil, Nabilah Mohamed Yussof, Nor Aini Ardini, Yunita Dewi Lestari, Widya |
| author_facet | Muhamad Zamil, Nabilah Mohamed Yussof, Nor Aini Ardini, Yunita Dewi Lestari, Widya |
| author_sort | Muhamad Zamil, Nabilah |
| building | IIUM Repository |
| collection | Online Access |
| description | Hypodontia is defined as the absence of one
to six teeth. There is high prevalence of hypodontia
recorded in Malaysia (2.8%). This study aimed to identify
any mutation of MSX1 in Malaysian family with
hypodontia and its clinical finding. We re-examined 4
individuals from a family of the previous PAX9 study.
Orthophantomogram (OPG) and intraoral photos were
re-assessed. Saliva was collected for genetic analysis.
Direct sequencing was done on exons 1 and 2 of MSX1. 2
out of 4 members (1A and 1D) in the family have anterior
hypodontia. Point mutation on exon1 of MSX1 (c.731G>A)
was observed in 1A (father) with missing 13 and 23 and
1C (carrier-son). c.732G>A was found on exon1 of MSX1
of his daughter (1D) with missing 32.MSX1 mutation is
involved in the occurrence of hypodontia in patient. |
| first_indexed | 2025-11-14T17:02:43Z |
| format | Proceeding Paper |
| id | iium-63481 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:02:43Z |
| publishDate | 2018 |
| publisher | Atlantis Press |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-634812018-06-29T00:51:28Z http://irep.iium.edu.my/63481/ Identification of MSX1 mutation in Malaysian hypodontia family Muhamad Zamil, Nabilah Mohamed Yussof, Nor Aini Ardini, Yunita Dewi Lestari, Widya RK Dentistry Hypodontia is defined as the absence of one to six teeth. There is high prevalence of hypodontia recorded in Malaysia (2.8%). This study aimed to identify any mutation of MSX1 in Malaysian family with hypodontia and its clinical finding. We re-examined 4 individuals from a family of the previous PAX9 study. Orthophantomogram (OPG) and intraoral photos were re-assessed. Saliva was collected for genetic analysis. Direct sequencing was done on exons 1 and 2 of MSX1. 2 out of 4 members (1A and 1D) in the family have anterior hypodontia. Point mutation on exon1 of MSX1 (c.731G>A) was observed in 1A (father) with missing 13 and 23 and 1C (carrier-son). c.732G>A was found on exon1 of MSX1 of his daughter (1D) with missing 32.MSX1 mutation is involved in the occurrence of hypodontia in patient. Atlantis Press 2018-02-09 Proceeding Paper PeerReviewed application/pdf en http://irep.iium.edu.my/63481/1/63841_Identification%20of%20MSX1%20mutation%20in%20Malaysian%20hypodontia%20family.pdf Muhamad Zamil, Nabilah and Mohamed Yussof, Nor Aini and Ardini, Yunita Dewi and Lestari, Widya (2018) Identification of MSX1 mutation in Malaysian hypodontia family. In: International Dental Conference of Sumatera Utara 2017 (IDCSU 2017), 7th-9th Dec. 2017, Sumatera Utara, Indonesia. https://www.atlantis-press.com/search?q=Idcsu&type=proceedings 10.2991/idcsu-17.2018.49 |
| spellingShingle | RK Dentistry Muhamad Zamil, Nabilah Mohamed Yussof, Nor Aini Ardini, Yunita Dewi Lestari, Widya Identification of MSX1 mutation in Malaysian hypodontia family |
| title | Identification of MSX1 mutation in Malaysian hypodontia family |
| title_full | Identification of MSX1 mutation in Malaysian hypodontia family |
| title_fullStr | Identification of MSX1 mutation in Malaysian hypodontia family |
| title_full_unstemmed | Identification of MSX1 mutation in Malaysian hypodontia family |
| title_short | Identification of MSX1 mutation in Malaysian hypodontia family |
| title_sort | identification of msx1 mutation in malaysian hypodontia family |
| topic | RK Dentistry |
| url | http://irep.iium.edu.my/63481/ http://irep.iium.edu.my/63481/ http://irep.iium.edu.my/63481/ http://irep.iium.edu.my/63481/1/63841_Identification%20of%20MSX1%20mutation%20in%20Malaysian%20hypodontia%20family.pdf |