The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings
Introduction: Hypertension related morbidities and mortalities around the world show a gradual increase and early detection and prevention are advocated. The Database of Genomic Variants (DGV) has associated variation in DNA sequences called copy number variation (CNV) with susceptibility...
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| Format: | Article |
| Language: | English |
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Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia.
2017
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| Online Access: | http://irep.iium.edu.my/63474/ http://irep.iium.edu.my/63474/1/Abstract-Book-for-IMJM-final-v2-37.pdf |
| _version_ | 1848786039115612160 |
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| author | Shaik Alaudeen, Siti Radziah Mohd Shah, Azarisman Shah A.Talib, Norlelawati Abdullah, Aszrin |
| author_facet | Shaik Alaudeen, Siti Radziah Mohd Shah, Azarisman Shah A.Talib, Norlelawati Abdullah, Aszrin |
| author_sort | Shaik Alaudeen, Siti Radziah |
| building | IIUM Repository |
| collection | Online Access |
| description | Introduction: Hypertension related morbidities and mortalities around the world show a gradual increase and early detection and prevention are advocated. The Database of Genomic Variants (DGV) has associated variation in DNA sequences called copy number variation (CNV) with susceptibility to common diseases. However, little is known about CNV role in essential hypertension. Thus, this study aimed to characterize the CNV esv27061 among prehypertensive and hypertensive young adults in Malaysia.
Materials and method: In this comparative cross-sectional study, 104 subjects living in Kuantan who gave voluntary consent to participate are recruited and divided into three
groups; control (43 subjects), prehypertensive (38 subjects) and mild hypertensive (23 subjects). An optimized droplet digital polymerase chain reaction (ddPCR) was used in
the determination of CNV esv27061 in this study.
Results: All subjects in the control (n=38; 88.4% gain), prehypertensive (n=33; 86.8% gain) and mild hypertensive (n=21; 91.3% gain) groups had CNV gain (copy number > 2) while 11.6% of control, 13.2% of prehypertensive and 8.7% of mild hypertensive subjects exhibited normal copies (copy number = 2).
Conclusion: The present preliminary finding
was consistent with the Database of Genomic Variants (DGV) which stated that CNV esv27061 showedmore gain than loss. |
| first_indexed | 2025-11-14T17:02:41Z |
| format | Article |
| id | iium-63474 |
| institution | International Islamic University Malaysia |
| institution_category | Local University |
| language | English |
| last_indexed | 2025-11-14T17:02:41Z |
| publishDate | 2017 |
| publisher | Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia. |
| recordtype | eprints |
| repository_type | Digital Repository |
| spelling | iium-634742018-08-30T03:02:46Z http://irep.iium.edu.my/63474/ The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings Shaik Alaudeen, Siti Radziah Mohd Shah, Azarisman Shah A.Talib, Norlelawati Abdullah, Aszrin R Medicine (General) RB Pathology Introduction: Hypertension related morbidities and mortalities around the world show a gradual increase and early detection and prevention are advocated. The Database of Genomic Variants (DGV) has associated variation in DNA sequences called copy number variation (CNV) with susceptibility to common diseases. However, little is known about CNV role in essential hypertension. Thus, this study aimed to characterize the CNV esv27061 among prehypertensive and hypertensive young adults in Malaysia. Materials and method: In this comparative cross-sectional study, 104 subjects living in Kuantan who gave voluntary consent to participate are recruited and divided into three groups; control (43 subjects), prehypertensive (38 subjects) and mild hypertensive (23 subjects). An optimized droplet digital polymerase chain reaction (ddPCR) was used in the determination of CNV esv27061 in this study. Results: All subjects in the control (n=38; 88.4% gain), prehypertensive (n=33; 86.8% gain) and mild hypertensive (n=21; 91.3% gain) groups had CNV gain (copy number > 2) while 11.6% of control, 13.2% of prehypertensive and 8.7% of mild hypertensive subjects exhibited normal copies (copy number = 2). Conclusion: The present preliminary finding was consistent with the Database of Genomic Variants (DGV) which stated that CNV esv27061 showedmore gain than loss. Kulliyyah (Faculty) of Medicine, International Islamic University Malaysia. 2017-09-15 Article PeerReviewed application/pdf en http://irep.iium.edu.my/63474/1/Abstract-Book-for-IMJM-final-v2-37.pdf Shaik Alaudeen, Siti Radziah and Mohd Shah, Azarisman Shah and A.Talib, Norlelawati and Abdullah, Aszrin (2017) The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings. International Medical Journal Malaysia, 16 (Supplementary Issue 1). p. 31. E-ISSN 1823-4631 http://iiumedic.net/imjm/v1/download/Volume%2016%20No%201%20Supp%201/Abstract-Book-for-IMJM-final-v2-37.pdf |
| spellingShingle | R Medicine (General) RB Pathology Shaik Alaudeen, Siti Radziah Mohd Shah, Azarisman Shah A.Talib, Norlelawati Abdullah, Aszrin The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings |
| title | The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings |
| title_full | The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings |
| title_fullStr | The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings |
| title_full_unstemmed | The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings |
| title_short | The identification of copy number variation of CNV esv27061 among young adults with hypertension: preliminary findings |
| title_sort | identification of copy number variation of cnv esv27061 among young adults with hypertension: preliminary findings |
| topic | R Medicine (General) RB Pathology |
| url | http://irep.iium.edu.my/63474/ http://irep.iium.edu.my/63474/ http://irep.iium.edu.my/63474/1/Abstract-Book-for-IMJM-final-v2-37.pdf |